SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		4 / 7 ILE A 277
PHE A 326
ILE A 272
PHE A 189
 None
 1.16A 2q6hA-5uqzA:
undetectable		 2q6hA-5uqzA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		4 / 7 ILE A 277
PHE A 326
ILE A 272
PHE A 189
 None
 1.17A 2qb4A-5uqzA:
undetectable		 2qb4A-5uqzA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		4 / 7 PRO A 416
ALA A 457
ALA A 453
PHE A 452
 None
 0.92A 2vcvL-5uqzA:
undetectable		 2vcvL-5uqzA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 12 LEU A 187
SER A 375
TYR A 422
TYR A 168
ALA A 427
 None
 1.48A 2vdmA-5uqzA:
0.2
2vdmB-5uqzA:
undetectable		 2vdmA-5uqzA:
9.73
2vdmB-5uqzA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		4 / 8 VAL A 257
TYR A 259
VAL A 293
VAL A 202
 None
 1.00A 2y05A-5uqzA:
undetectable
2y05B-5uqzA:
undetectable		 2y05A-5uqzA:
14.24
2y05B-5uqzA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 10 LEU A 364
ILE A 384
SER A 346
SER A 344
GLY A 426
 None
 1.37A 3ijxB-5uqzA:
undetectable
3ijxD-5uqzA:
undetectable		 3ijxB-5uqzA:
16.06
3ijxD-5uqzA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		3 / 3 LYS A 196
LYS A 242
PRO A 241
 None
 1.09A 4dv1L-5uqzA:
undetectable		 4dv1L-5uqzA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		4 / 7 TYR A 144
PRO A 470
GLN A 152
TYR A 151
 None
 1.42A 4grqA-5uqzA:
undetectable
4grqC-5uqzA:
undetectable		 4grqA-5uqzA:
23.58
4grqC-5uqzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 12 ILE A 262
ILE A 190
ASP A 298
LEU A 187
ILE A 272
 None
 1.07A 4m2xC-5uqzA:
undetectable		 4m2xC-5uqzA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 9 PRO A 461
TYR A 423
GLY A 426
SER A 376
GLY A 374
 None
 1.27A 4mm5A-5uqzA:
undetectable		 4mm5A-5uqzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 9 PRO A 461
TYR A 423
GLY A 426
SER A 376
GLY A 374
 None
 1.23A 4mmbA-5uqzA:
undetectable		 4mmbA-5uqzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		4 / 6 ASN A 264
ILE A 272
ILE A 262
VAL A 275
 None
 0.98A 4olmA-5uqzA:
undetectable		 4olmA-5uqzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		3 / 3 ARG A 180
ASN A 340
ASP A 335
 None
 0.90A 5gwxA-5uqzA:
undetectable		 5gwxA-5uqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 12 GLY A 401
GLY A 424
ASN A 400
ASN A 395
ASP A 408
 None
None
None
None
CA  A 501 ( 4.3A)
 1.31A 5yn6A-5uqzA:
undetectable		 5yn6A-5uqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5uqz GLUCAN-BINDING
PROTEIN C, GBPC
(Streptococcus
mutans) 		5 / 12 GLY A 401
GLY A 424
ASN A 400
ASN A 395
ASP A 408
 None
None
None
None
CA  A 501 ( 4.3A)
 1.30A 5ynmA-5uqzA:
undetectable		 5ynmA-5uqzA:
undetectable