SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ur0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 0.94A 1c6zA-5ur0A:
undetectable		 1c6zA-5ur0A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 7 ASN A 314
TYR A 318
ASN A 152
TYR A 312
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.5A)
None
OCS  A 149 ( 4.1A)
 0.93A 1dssG-5ur0A:
51.6		 1dssG-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		7 / 7 SER A 148
THR A 150
ASN A 152
CYH A 153
TYR A 312
ASN A 314
TYR A 318
 OCS  A 149 ( 3.5A)
OCS  A 149 ( 3.8A)
None
None
OCS  A 149 ( 4.1A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.5A)
 0.18A 1dssG-5ur0A:
51.6		 1dssG-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 8 ASN A 314
TYR A 318
ASN A 152
TYR A 312
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.5A)
None
OCS  A 149 ( 4.1A)
 0.92A 1dssR-5ur0A:
51.4		 1dssR-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		8 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
HIS A 176
TYR A 312
ASN A 314
TYR A 318
 OCS  A 149 ( 3.5A)
OCS  A 149 ( 3.8A)
None
None
OCS  A 149 ( 4.0A)
OCS  A 149 ( 4.1A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.5A)
 0.33A 1dssR-5ur0A:
51.4		 1dssR-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 9 ILE A 167
VAL A 214
GLY A 215
ALA A 158
LEU A 154
 None
 0.96A 1e7bA-5ur0A:
undetectable		 1e7bA-5ur0A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 9 PHE A   9
LEU A  58
VAL A  67
VAL A  74
ILE A  31
 None
 1.28A 1gebA-5ur0A:
undetectable		 1gebA-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 7 PHE A   9
VAL A  67
VAL A  74
ILE A  31
 None
 0.97A 1p7rA-5ur0A:
undetectable		 1p7rA-5ur0A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 9 PHE A   9
LEU A  58
VAL A  67
VAL A  74
ILE A  31
 None
 1.25A 2a1oB-5ur0A:
undetectable		 2a1oB-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 0.93A 2q64A-5ur0A:
undetectable		 2q64A-5ur0A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 8 ASN A 314
TYR A 318
ASN A 152
TYR A 312
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.5A)
None
OCS  A 149 ( 4.1A)
 0.94A 3dmtC-5ur0A:
49.7		 3dmtC-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		8 / 8 SER A 148
THR A 150
ASN A 152
CYH A 153
HIS A 176
TYR A 312
ASN A 314
TYR A 318
 OCS  A 149 ( 3.5A)
OCS  A 149 ( 3.8A)
None
None
OCS  A 149 ( 4.0A)
OCS  A 149 ( 4.1A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.5A)
 0.24A 3dmtC-5ur0A:
49.7		 3dmtC-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 9 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 0.94A 3ekqB-5ur0A:
undetectable		 3ekqB-5ur0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 1.00A 3ekxB-5ur0A:
undetectable		 3ekxB-5ur0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 GLY A 215
GLY A 223
ALA A 211
THR A 226
ALA A 155
 None
 1.10A 3g88A-5ur0A:
undetectable		 3g88A-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 GLY A 215
GLY A 223
ALA A 211
THR A 226
ALA A 155
 None
 1.10A 3g88B-5ur0A:
undetectable		 3g88B-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 GLY A 215
GLY A 223
ALA A 211
THR A 226
ALA A 155
 None
 1.08A 3g89A-5ur0A:
4.6		 3g89A-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 GLY A 215
GLY A 223
ALA A 211
THR A 226
ALA A 155
 None
 1.09A 3g89B-5ur0A:
undetectable		 3g89B-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 TYR A 312
ASN A 222
GLY A 209
ALA A 210
GLY A 215
 OCS  A 149 ( 4.1A)
None
None
None
None
 0.90A 3hs6B-5ur0A:
undetectable		 3hs6B-5ur0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 0.97A 3k4vC-5ur0A:
undetectable		 3k4vC-5ur0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 6 ASN A 320
LEU A 323
ASP A 324
LYS A 327
 None
 1.10A 3lslG-5ur0A:
undetectable		 3lslG-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 0.98A 3nduC-5ur0A:
undetectable		 3nduC-5ur0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 5 ASN A 145
ALA A 123
PRO A 122
ALA A 213
 None
 1.33A 3twpD-5ur0A:
undetectable		 3twpD-5ur0A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 12 TYR A 312
ASN A 222
GLY A 209
ALA A 210
GLY A 215
 OCS  A 149 ( 4.1A)
None
None
None
None
 0.82A 4e1gA-5ur0A:
undetectable		 4e1gA-5ur0A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 SER A 148
LEU A 154
PRO A 156
VAL A 129
THR A 127
 OCS  A 149 ( 3.5A)
None
None
None
PGE  A 402 (-4.7A)
 1.23A 4uuuB-5ur0A:
undetectable		 4uuuB-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 6 ARG A  11
ASP A  48
VAL A 237
ASP A 313
 None
 1.40A 4xqeA-5ur0A:
10.5		 4xqeA-5ur0A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 6 ARG A  11
ASP A  48
VAL A 237
ASP A 313
 None
 1.41A 4xqeB-5ur0A:
10.6		 4xqeB-5ur0A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 6 CYH A 300
ILE A 299
ILE A 255
ASP A 256
 None
 1.06A 4z4cA-5ur0A:
3.1		 4z4cA-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		3 / 3 THR A 151
ALA A 147
ASN A 152
 None
 0.57A 5ersA-5ur0A:
undetectable		 5ersA-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 7 LEU A 154
ILE A 255
LYS A 307
VAL A 308
 None
 1.02A 5jh7C-5ur0A:
3.0		 5jh7C-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 9 VAL A  28
ILE A  31
GLY A  13
ILE A  12
ILE A   4
 None
None
None
NAD  A 401 (-4.1A)
None
 0.93A 5kqxB-5ur0A:
undetectable		 5kqxB-5ur0A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		4 / 6 PHE A 230
VAL A 175
ALA A 229
THR A 150
 None
None
None
OCS  A 149 ( 3.8A)
 1.02A 5t7bA-5ur0A:
3.5		 5t7bA-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		3 / 3 ARG A  18
HIS A  51
ARG A  11
 None
 1.16A 6dwdD-5ur0A:
undetectable		 6dwdD-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Naegleria
gruberi) 		5 / 11 ILE A 271
LEU A 272
PRO A 156
THR A 151
ASN A 152
 None
 1.50A 6hupA-5ur0A:
undetectable
6hupB-5ur0A:
undetectable		 6hupA-5ur0A:
17.98
6hupB-5ur0A:
14.12