SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		4 / 8 ASP A 116
TRP A 117
ARG A 124
THR A 141
 None
 1.48A 1ceaA-5uroA:
undetectable
1ceaB-5uroA:
undetectable		 1ceaA-5uroA:
11.31
1ceaB-5uroA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		4 / 6 GLY A  45
ASP A 116
TYR A  75
TRP A 251
 None
 1.26A 1kf6M-5uroA:
undetectable
1kf6N-5uroA:
undetectable		 1kf6M-5uroA:
21.36
1kf6N-5uroA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		5 / 12 ILE A 327
ASN A 332
ALA A 307
VAL A  40
LEU A  63
 None
 1.08A 1xdkA-5uroA:
undetectable		 1xdkA-5uroA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		3 / 3 TRP A 251
GLN A 240
TRP A  53
 None
 1.34A 2vqyA-5uroA:
1.7		 2vqyA-5uroA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		4 / 5 HIS A  44
ASP A  48
TYR A  75
PRO A 248
 None
 1.43A 3fo7A-5uroA:
undetectable		 3fo7A-5uroA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		4 / 5 HIS A  44
ASP A  48
TYR A  75
PRO A 248
 None
 1.44A 3h1xA-5uroA:
undetectable		 3h1xA-5uroA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		4 / 4 ILE A 327
GLN A  56
VAL A 323
PHE A 137
 None
 1.19A 3ieoA-5uroA:
undetectable		 3ieoA-5uroA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		7 / 12 ASP A 116
PHE A 165
TYR A 167
TYR A 252
LEU A 289
HIS A 313
TRP A 314
 None
 0.63A 4j03A-5uroA:
40.1		 4j03A-5uroA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		4 / 5 TYR A 233
GLY A  45
ASP A 116
VAL A 309
 None
 1.07A 4nkvD-5uroA:
undetectable		 4nkvD-5uroA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		5 / 11 THR A 125
ALA A 126
GLY A 118
GLY A 119
ALA A 120
 None
 0.90A 5lf3K-5uroA:
undetectable
5lf3L-5uroA:
undetectable		 5lf3K-5uroA:
19.88
5lf3L-5uroA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		5 / 11 THR A 125
ALA A 126
GLY A 118
GLY A 119
ALA A 120
 None
 0.91A 5lf3Y-5uroA:
undetectable
5lf3Z-5uroA:
undetectable		 5lf3Y-5uroA:
19.88
5lf3Z-5uroA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		5 / 11 THR A 125
ALA A 126
GLY A 118
GLY A 119
ALA A 120
 None
 0.97A 5lf7Y-5uroA:
undetectable
5lf7Z-5uroA:
undetectable		 5lf7Y-5uroA:
19.88
5lf7Z-5uroA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5uro PREDICTED PROTEIN
(Trichoderma
reesei) 		3 / 3 VAL A  41
LYS A 134
MET A 276
 None
 0.88A 5nknA-5uroA:
undetectable		 5nknA-5uroA:
12.20