SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5us8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 8 ASP A  23
GLY A  21
GLY A  20
TYR A 183
 None
 0.91A 1ekjA-5us8A:
undetectable
1ekjB-5us8A:
undetectable		 1ekjA-5us8A:
20.00
1ekjB-5us8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 7 ASP A  23
GLY A  21
GLY A  20
TYR A 183
 None
 0.95A 1ekjE-5us8A:
undetectable
1ekjF-5us8A:
undetectable		 1ekjE-5us8A:
20.00
1ekjF-5us8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 6 ALA A 200
GLU A 293
TYR A 191
ILE A 291
 None
 1.03A 1xvaA-5us8A:
2.6
1xvaB-5us8A:
2.9		 1xvaA-5us8A:
20.73
1xvaB-5us8A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 12 PHE A 241
ALA A 248
ALA A  87
ALA A  84
LEU A 297
 None
 1.27A 2x2nB-5us8A:
undetectable		 2x2nB-5us8A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 12 PHE A 241
VAL A 239
ALA A  87
ALA A  84
LEU A 297
 None
 1.29A 2x2nC-5us8A:
undetectable		 2x2nC-5us8A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 8 GLY A 367
GLY A 272
GLY A 269
HIS A 271
ILE A 267
 None
 1.15A 3d41A-5us8A:
2.3		 3d41A-5us8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		3 / 3 THR A 201
LYS A 155
GLU A 203
 None
 0.91A 3ijdB-5us8A:
undetectable		 3ijdB-5us8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 6 GLU A  80
ILE A 105
PHE A 337
ALA A 108
 None
 0.94A 3pgyA-5us8A:
undetectable
3pgyB-5us8A:
2.4		 3pgyA-5us8A:
26.53
3pgyB-5us8A:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 12 GLY A 268
GLY A 272
TYR A 370
VAL A 237
GLY A 296
 None
 1.00A 3sglA-5us8A:
3.0		 3sglA-5us8A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 5 LEU A 249
LEU A 299
GLY A 296
GLY A 268
 None
 0.67A 3si7C-5us8A:
undetectable
3si7D-5us8A:
undetectable		 3si7C-5us8A:
20.88
3si7D-5us8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 8 ASP A 128
ALA A  17
SER A 130
ASP A 136
 None
 0.90A 4k0bB-5us8A:
undetectable		 4k0bB-5us8A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 8 ASP A 128
ALA A  17
SER A 130
ASP A 136
 None
 0.95A 4l7iB-5us8A:
undetectable		 4l7iB-5us8A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 12 MET A 343
ARG A 345
ALA A 348
ALA A  89
GLY A 324
 None
 0.92A 4oaeA-5us8A:
undetectable		 4oaeA-5us8A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 11 SER A 186
GLY A  20
GLY A  21
LEU A  28
ILE A  56
 None
 1.16A 4pghA-5us8A:
2.4		 4pghA-5us8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 6 TYR A 332
ASN A 101
GLU A 280
GLU A 203
 None
 1.45A 4twdG-5us8A:
undetectable
4twdH-5us8A:
undetectable		 4twdG-5us8A:
22.32
4twdH-5us8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		3 / 3 ARG A 107
ASN A 196
ASP A  49
 None
 0.92A 5gwxA-5us8A:
3.6		 5gwxA-5us8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		5 / 12 TYR A 143
GLY A 334
GLY A 111
LEU A 114
GLY A 134
 None
 1.13A 5i75A-5us8A:
undetectable		 5i75A-5us8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5us8 ARGININOSUCCINATE
SYNTHASE
(Bordetella
pertussis) 		4 / 6 GLY A 328
ASP A 136
ILE A 284
TYR A  99
 None
 1.06A 5iwuA-5us8A:
undetectable		 5iwuA-5us8A:
20.81