SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5usc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 GLY A 131
THR A 187
THR A 158
ILE A 156
 None
 1.00A 1gtnJ-5uscA:
undetectable
1gtnK-5uscA:
undetectable		 1gtnJ-5uscA:
12.40
1gtnK-5uscA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 THR A 194
HIS A 190
TYR A 155
LEU A 157
 None
 1.07A 1ibgL-5uscA:
undetectable		 1ibgL-5uscA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 PHE A 128
ALA A 118
LEU A  90
ASP A 191
 None
 1.07A 2bxkA-5uscA:
undetectable		 2bxkA-5uscA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 GLY A 177
TYR A 155
ASP A  36
ASP A  38
 None
 1.09A 2g72B-5uscA:
3.5		 2g72B-5uscA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 ALA A  30
ALA A  80
GLY A  21
GLY A  23
ILE A  25
 None
 1.26A 2v7bA-5uscA:
6.0		 2v7bA-5uscA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 ALA A  30
ALA A  80
GLY A  21
GLY A  23
ILE A  25
 None
 1.25A 2v7bB-5uscA:
5.7		 2v7bB-5uscA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 ILE A  25
ALA A  32
THR A 178
VAL A  78
VAL A 107
 None
 1.24A 3me6C-5uscA:
undetectable		 3me6C-5uscA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 5 LEU A 367
GLN A 373
THR A 374
HIS A 322
 None
 1.45A 3n58C-5uscA:
4.5		 3n58C-5uscA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 GLY A 108
VAL A 107
ASP A 106
THR A  86
 None
 1.04A 3vqrA-5uscA:
3.7		 3vqrA-5uscA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 5 GLY A 108
VAL A 107
ASP A 106
THR A  86
 None
 1.03A 3vqrB-5uscA:
4.8		 3vqrB-5uscA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 7 ALA A  32
LEU A 149
THR A 178
SER A 180
 None
 0.84A 4iklA-5uscA:
undetectable
4iklB-5uscA:
undetectable		 4iklA-5uscA:
15.36
4iklB-5uscA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 SER A 180
ALA A  32
LEU A 149
THR A 178
 None
 0.83A 4iklA-5uscA:
undetectable
4iklB-5uscA:
undetectable		 4iklA-5uscA:
15.36
4iklB-5uscA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 PHE A 150
GLY A  23
GLY A 141
SER A 137
ALA A  80
 None
 1.13A 4krhB-5uscA:
4.9		 4krhB-5uscA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 HIS A 161
MET A 160
GLY A 108
ASP A 106
THR A 110
 None
 1.14A 4mubA-5uscA:
undetectable		 4mubA-5uscA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 GLY A  26
THR A 178
VAL A  59
ASP A  45
ILE A  25
 None
 1.18A 4pghA-5uscA:
5.3		 4pghA-5uscA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 HIS A 199
ILE A 247
HIS A 132
VAL A 107
PRO A  82
 None
 1.43A 5z0fA-5uscA:
undetectable
5z0fB-5uscA:
undetectable		 5z0fA-5uscA:
12.91
5z0fB-5uscA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 GLY A  27
ILE A  41
VAL A  78
LEU A  31
ALA A  32
 None
 1.07A 6bq4B-5uscA:
6.5		 6bq4B-5uscA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A  30
VAL A  17
GLY A  21
LEU A  76
ILE A  41
 None
 1.12A 6dgxB-5uscA:
undetectable		 6dgxB-5uscA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5usc PREPHENATE
DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 ASP A 191
HIS A 161
HIS A 190
GLU A 117
 None
 1.26A 6mn4B-5uscA:
undetectable		 6mn4B-5uscA:
21.41