SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5usf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 ASP A 574
ASP A 563
LYS A 385
 None
 1.11A 1lqtB-5usfA:
3.7		 1lqtB-5usfA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 ASP A 574
ASP A 563
LYS A 385
 None
 1.11A 1lquB-5usfA:
undetectable		 1lquB-5usfA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		5 / 11 THR A 365
ALA A 506
PRO A 368
ALA A 529
PHE A 468
 None
 1.33A 2admA-5usfA:
2.3		 2admA-5usfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 TRP A 127
ALA A 421
VAL A 130
 None
 0.78A 2izqA-5usfA:
undetectable
2izqB-5usfA:
undetectable		 2izqA-5usfA:
1.88
2izqB-5usfA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		4 / 5 LEU A 492
GLY A 496
ILE A 142
ILE A 139
 None
 0.84A 2q9rA-5usfA:
undetectable		 2q9rA-5usfA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		5 / 12 ILE A 133
ILE A 142
THR A 138
CYH A 145
VAL A 188
 None
 1.00A 2qo5A-5usfA:
undetectable		 2qo5A-5usfA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		4 / 7 GLY A  50
GLY A 182
GLN A 180
PHE A  69
 None
YSA  A 701 (-3.3A)
None
None
 0.80A 2qwxA-5usfA:
undetectable
2qwxB-5usfA:
2.2		 2qwxA-5usfA:
15.74
2qwxB-5usfA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 SER A 314
ASP A 311
ASP A 294
 None
 0.87A 3iv6C-5usfA:
1.4		 3iv6C-5usfA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		5 / 12 ILE A 499
ALA A 495
LEU A 492
LEU A 481
GLN A 160
 None
 1.10A 3ix9B-5usfA:
undetectable		 3ix9B-5usfA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 ALA A 421
VAL A 130
TRP A 127
 None
 0.78A 3l8lA-5usfA:
undetectable
3l8lB-5usfA:
undetectable		 3l8lA-5usfA:
1.88
3l8lB-5usfA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		4 / 7 PHE A 528
ALA A 529
THR A 533
LEU A 509
 None
 0.80A 3t3sC-5usfA:
undetectable		 3t3sC-5usfA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		4 / 5 LEU A 181
GLY A 182
PHE A  39
ASN A  56
 YSA  A 701 (-3.6A)
YSA  A 701 (-3.3A)
YSA  A 701 (-4.6A)
None
 1.22A 3uq6B-5usfA:
undetectable		 3uq6B-5usfA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 ASP A 263
ARG A 272
THR A 147
 None
 0.72A 4i13A-5usfA:
undetectable		 4i13A-5usfA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 LYS A 385
LYS A 578
ALA A 562
 None
 1.45A 4ot2A-5usfA:
undetectable		 4ot2A-5usfA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		3 / 3 ASP A 263
ARG A 272
THR A 147
 None
 0.72A 4p3rA-5usfA:
undetectable		 4p3rA-5usfA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		4 / 5 ARG A 546
PRO A 548
ILE A 547
ASP A 389
 None
 1.45A 4z4hA-5usfA:
2.7		 4z4hA-5usfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5usf TYROSYL-TRNA
SYNTHETASE, PUTATIVE
(Leishmania
donovani) 		4 / 8 TYR A 284
CYH A 321
TYR A 298
LEU A 318
 None
 1.33A 5kxiA-5usfA:
undetectable
5kxiB-5usfA:
undetectable		 5kxiA-5usfA:
19.70
5kxiB-5usfA:
20.73