SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5usw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		6 / 11 GLY A 110
ALA A 111
ASP A 112
ILE A  81
THR A  97
VAL A 102
 None
 1.25A 1ohrA-5uswA:
undetectable		 1ohrA-5uswA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		5 / 12 ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
GOL  A 303 ( 3.9A)
None
 0.70A 1q8jA-5uswA:
13.8		 1q8jA-5uswA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		6 / 11 GLY A 110
ALA A 111
ASP A 112
ILE A  81
THR A  97
VAL A 102
 None
 1.33A 2nnpA-5uswA:
undetectable		 2nnpA-5uswA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		5 / 12 ASP A  56
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
GOL  A 303 ( 3.9A)
None
 1.22A 2ycjA-5uswA:
20.4		 2ycjA-5uswA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		5 / 12 ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
GOL  A 303 ( 3.9A)
None
 0.73A 2ycjA-5uswA:
20.4		 2ycjA-5uswA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 5 GLY A  32
ARG A  77
GLN A  43
MET A  47
 None
 1.32A 3qx3A-5uswA:
undetectable		 3qx3A-5uswA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 5 GLY A  32
ARG A  77
GLN A  43
MET A  47
 None
 1.44A 3qx3B-5uswA:
undetectable		 3qx3B-5uswA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 7 GLY A 110
ALA A 111
ASP A 112
ILE A  81
 None
 0.76A 3t3cA-5uswA:
undetectable		 3t3cA-5uswA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		3 / 3 PHE A 190
LYS A 221
SER A 222
 GOL  A 303 (-4.7A)
GOL  A 303 (-2.8A)
None
 0.57A 3tyeB-5uswA:
34.5		 3tyeB-5uswA:
37.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 8 GLY A 189
PHE A 190
LYS A 221
SER A 222
 None
GOL  A 303 (-4.7A)
GOL  A 303 (-2.8A)
None
 0.39A 3tzfB-5uswA:
36.5		 3tzfB-5uswA:
60.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 6 GLY A  59
GLU A  74
ASP A  96
GLU A 122
 None
None
GOL  A 303 ( 4.7A)
None
 1.02A 3vywC-5uswA:
undetectable		 3vywC-5uswA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		6 / 12 ASP A  56
ASP A  96
ASN A 115
ASP A 185
GLY A 217
SER A 219
 None
GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
GOL  A 303 ( 3.9A)
None
 0.78A 4djeB-5uswA:
20.4		 4djeB-5uswA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		5 / 12 ASP A  56
ASP A  96
ASN A 115
GLY A 217
SER A 219
 None
GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 ( 3.9A)
None
 0.71A 4djfB-5uswA:
7.3		 4djfB-5uswA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 5 LEU A 113
ASP A  96
ARG A 255
ILE A  20
 None
GOL  A 303 ( 4.7A)
GOL  A 303 ( 4.0A)
None
 1.39A 4mwrA-5uswA:
undetectable		 4mwrA-5uswA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		3 / 3 VAL A 230
SER A 237
MET A 218
 None
 0.82A 5ikqA-5uswA:
undetectable		 5ikqA-5uswA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		4 / 7 VAL A 268
ILE A 245
SER A 276
THR A 272
 None
 0.83A 5vkqA-5uswA:
undetectable
5vkqD-5uswA:
undetectable		 5vkqA-5uswA:
10.72
5vkqD-5uswA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
 0.33A 5vopA-5uswA:
17.9		 5vopA-5uswA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5usw DIHYDROPTEROATE
SYNTHASE
(Aliivibrio
fischeri) 		3 / 3 ASP A  96
ASN A 115
ASP A 185
 GOL  A 303 ( 4.7A)
GOL  A 303 (-3.5A)
GOL  A 303 (-2.8A)
 0.36A 5vopB-5uswA:
2.9		 5vopB-5uswA:
24.78