SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5usx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 6 THR A  36
GLY A  42
LYS A  70
TYR A  19
 None
FAD  A 402 (-3.4A)
None
None
 1.23A 1gtiC-5usxA:
undetectable		 1gtiC-5usxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 TYR A 104
ASP A  83
ILE A  85
LEU A  97
VAL A  96
 None
None
FAD  A 402 (-4.2A)
None
None
 1.22A 1r30A-5usxA:
undetectable		 1r30A-5usxA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 LEU A 165
ILE A 241
ALA A 242
ALA A 137
LEU A 174
 None
 1.25A 2japC-5usxA:
5.1		 2japC-5usxA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 7 PRO A  54
LEU A  65
LEU A  44
ILE A 296
 None
None
FAD  A 402 (-4.1A)
None
 1.04A 3u5jA-5usxA:
undetectable		 3u5jA-5usxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 8 PRO A  54
VAL A  50
LEU A  65
ILE A 296
 None
FAD  A 402 (-3.4A)
None
None
 0.91A 3u5kA-5usxA:
undetectable		 3u5kA-5usxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 8 PRO A  54
VAL A  50
LEU A  65
ILE A 296
 None
FAD  A 402 (-3.4A)
None
None
 0.91A 3u5kC-5usxA:
undetectable		 3u5kC-5usxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 8 PRO A  54
VAL A  50
LEU A  65
LEU A  44
ILE A 296
 None
FAD  A 402 (-3.4A)
None
FAD  A 402 (-4.1A)
None
 1.10A 3u5kD-5usxA:
undetectable		 3u5kD-5usxA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 LEU A 223
LEU A 208
ILE A 175
GLY A 220
LEU A 234
 None
 0.99A 4lmnA-5usxA:
undetectable		 4lmnA-5usxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 LEU A  97
THR A 113
ILE A 111
GLN A 255
LEU A 256
 None
FAD  A 402 (-4.1A)
None
None
None
 1.27A 4o5fA-5usxA:
undetectable
4o5fB-5usxA:
undetectable		 4o5fA-5usxA:
21.19
4o5fB-5usxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 GLN A 255
LEU A 256
LEU A  97
THR A 113
ILE A 111
 None
None
None
FAD  A 402 (-4.1A)
None
 1.24A 4o5fA-5usxA:
undetectable
4o5fB-5usxA:
undetectable		 4o5fA-5usxA:
21.19
4o5fB-5usxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA302_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 5 PRO A  16
MET A  66
LEU A  60
TRP A  53
 FAD  A 402 (-3.9A)
None
None
None
 1.26A 4ww7A-5usxA:
0.0		 4ww7A-5usxA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 8 ALA A 284
GLY A 302
ALA A  21
GLY A  18
 None
 0.68A 4zjzA-5usxA:
undetectable		 4zjzA-5usxA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 LEU A  97
THR A 113
ILE A 111
GLN A 255
LEU A 256
 None
FAD  A 402 (-4.1A)
None
None
None
 1.25A 5b8hA-5usxA:
undetectable
5b8hB-5usxA:
undetectable		 5b8hA-5usxA:
23.48
5b8hB-5usxA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 GLN A 255
LEU A 256
LEU A  97
THR A 113
ILE A 111
 None
None
None
FAD  A 402 (-4.1A)
None
 1.19A 5b8hA-5usxA:
undetectable
5b8hB-5usxA:
undetectable		 5b8hA-5usxA:
23.48
5b8hB-5usxA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		5 / 12 GLY A 217
GLY A 132
VAL A 221
LEU A 212
GLY A 213
 None
 0.96A 5wyqA-5usxA:
undetectable		 5wyqA-5usxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 7 ILE A 110
PHE A  90
LEU A 109
ILE A  80
 None
 0.86A 6b5vA-5usxA:
undetectable
6b5vC-5usxA:
undetectable		 6b5vA-5usxA:
12.59
6b5vC-5usxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 7 ILE A 110
PHE A  90
LEU A 109
ILE A  80
 None
 0.86A 6b5vC-5usxA:
undetectable
6b5vD-5usxA:
undetectable		 6b5vC-5usxA:
12.59
6b5vD-5usxA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5usx THIOREDOXIN
REDUCTASE
(Vibrio
vulnificus) 		4 / 7 ILE A 110
PHE A  90
LEU A 109
ILE A  80
 None
 0.87A 6b5vB-5usxA:
undetectable
6b5vD-5usxA:
undetectable		 6b5vB-5usxA:
12.59
6b5vD-5usxA:
12.59