SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A  86
VAL A  89
GLU A  84
LEU A  34
ILE A  11
 FAD  A 400 (-4.1A)
None
None
None
None
 0.86A 1t6zA-5uthA:
undetectable		 1t6zA-5uthA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 MET A 114
ALA A 113
VAL A 275
GLY A  14
ILE A  13
 None
None
None
FAD  A 400 (-3.1A)
FAD  A 400 (-4.7A)
 1.00A 2dcfA-5uthA:
undetectable		 2dcfA-5uthA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 SER A  15
HIS A 105
ASP A 102
 FAD  A 400 (-3.6A)
SO4  A 402 (-3.6A)
None
 0.65A 2oxtA-5uthA:
undetectable		 2oxtA-5uthA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 MET A 114
ALA A 113
GLY A  14
ILE A  13
 None
None
FAD  A 400 (-3.1A)
FAD  A 400 (-4.7A)
 0.86A 2zm9A-5uthA:
undetectable		 2zm9A-5uthA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 307
ALA A 109
ALA A  26
GLY A 296
VAL A 253
 None
 1.08A 3c6gA-5uthA:
undetectable		 3c6gA-5uthA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  75
GLY A  43
GLY A  42
LEU A  81
GLY A  63
 SO4  A 401 ( 4.8A)
FAD  A 400 (-3.2A)
FAD  A 400 (-4.4A)
SO4  A 401 ( 4.6A)
None
 1.12A 3vasB-5uthA:
3.2		 3vasB-5uthA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 VAL A 134
THR A 130
GLU A 126
GLU A 127
 None
 1.24A 4l78A-5uthA:
undetectable		 4l78A-5uthA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 248
ARG A 245
MET A  46
 FAD  A 400 (-4.6A)
FAD  A 400 ( 3.6A)
None
 0.97A 4m11C-5uthA:
undetectable		 4m11C-5uthA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  44
GLY A  19
PHE A  41
ALA A 299
ALA A  18
 FAD  A 400 (-3.2A)
None
None
None
FAD  A 400 (-3.3A)
 1.23A 4pclA-5uthA:
3.4		 4pclA-5uthA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ALA A 278
GLY A 296
ALA A  22
GLY A  19
 None
 0.63A 4zjzA-5uthA:
undetectable		 4zjzA-5uthA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 GLY A  19
SER A  15
GLU A  37
ILE A 111
ALA A 278
 None
FAD  A 400 (-3.6A)
None
None
None
 1.07A 5entC-5uthA:
undetectable		 5entC-5uthA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLU A 304
GLY A 296
ALA A 298
ALA A  22
ILE A  12
 None
 1.14A 5yk2A-5uthA:
undetectable		 5yk2A-5uthA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5uth THIOREDOXIN
REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 111
GLY A 279
ALA A 113
ALA A 292
ALA A 289
 None
FAD  A 400 (-3.2A)
None
FAD  A 400 (-3.4A)
FAD  A 400 (-3.4A)
 1.08A 5zw4A-5uthA:
3.5		 5zw4A-5uthA:
22.22