SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5utk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KW0_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	5utk	ANGIOPOIETIN-1 RECEPTOR (Homo sapiens)	5 / 12	LEU A 601 LEU A 559 SER A 555 LEU A 634 THR A 562	None	1.32A	1kw0A-5utkA: undetectable	1kw0A-5utkA: 24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W67_C_VIVC301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5utk	ANGIOPOIETIN-1 RECEPTOR (Homo sapiens)	5 / 12	VAL A 486 ALA A 461 PHE A 536 LEU A 481 VAL A 502	None	1.17A	3w67C-5utkA: undetectable	3w67C-5utkA: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_2 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	5utk	ANGIOPOIETIN-1 RECEPTOR (Homo sapiens)	4 / 4	ASN A 560 SER A 666 LEU A 634 THR A 562	None	1.43A	4an2A-5utkA: undetectable	4an2A-5utkA: 22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YK2_A_ERYA501_0 (PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER)	5utk	ANGIOPOIETIN-1 RECEPTOR (Homo sapiens)	5 / 11	GLU A 643 GLY A 664 ASP A 663 PRO A 639 ILE A 667	None	1.22A	5yk2A-5utkA: undetectable	5yk2A-5utkA: 21.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1KW0_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","5utk","ANGIOPOIETIN-1 RECEPTOR","Homo sapiens",5,"LEU A 601;LEU A 559;SER A 555;LEU A 634;THR A 562","None","1.32A","1kw0A-5utkA:undetectable","1kw0A-5utkA:24.10"],["3W67_C_VIVC301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5utk","ANGIOPOIETIN-1 RECEPTOR","Homo sapiens",5,"VAL A 486;ALA A 461;PHE A 536;LEU A 481;VAL A 502","None","1.17A","3w67C-5utkA:undetectable","3w67C-5utkA:21.61"],["4AN2_A_EUIA1382_2","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","5utk","ANGIOPOIETIN-1 RECEPTOR","Homo sapiens",4,"ASN A 560;SER A 666;LEU A 634;THR A 562","None","1.43A","4an2A-5utkA:undetectable","4an2A-5utkA:22.32"],["5YK2_A_ERYA501_0","PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER","5utk","ANGIOPOIETIN-1 RECEPTOR","Homo sapiens",5,"GLU A 643;GLY A 664;ASP A 663;PRO A 639;ILE A 667","None","1.22A","5yk2A-5utkA:undetectable","5yk2A-5utkA:21.51"]]