SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		6 / 11 ILE A  25
GLU A 125
ILE A  88
ILE A 133
ILE A  23
THR A  10
 None
 1.44A 1dyrA-5utoA:
undetectable		 1dyrA-5utoA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 8 SER A  97
ILE A  25
MET A 123
SER A 261
 None
 1.16A 1kb9A-5utoA:
undetectable
1kb9C-5utoA:
undetectable
1kb9D-5utoA:
undetectable
1kb9E-5utoA:
undetectable		 1kb9A-5utoA:
undetectable
1kb9C-5utoA:
undetectable
1kb9D-5utoA:
undetectable
1kb9E-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 LEU A 149
MET A 152
ILE A 124
ILE A  88
TYR A  98
 None
None
PLM  A 301 ( 4.9A)
None
None
 1.13A 1osvB-5utoA:
undetectable		 1osvB-5utoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 LEU A 149
MET A 152
ILE A 124
ILE A  88
TYR A  98
 None
None
PLM  A 301 ( 4.9A)
None
None
 1.09A 1ot7B-5utoA:
undetectable		 1ot7B-5utoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		6 / 12 LEU A 160
TYR A 280
GLY A 277
TYR A 128
LEU A 120
PHE A 225
 PLM  A 301 ( 4.4A)
None
PLM  A 301 (-3.8A)
None
None
None
 1.40A 1pj7A-5utoA:
undetectable		 1pj7A-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 5 SER A  56
ASP A  33
PRO A  60
SER A  55
 None
 1.40A 2hdnA-5utoA:
undetectable
2hdnB-5utoA:
undetectable
2hdnD-5utoA:
4.0		 2hdnA-5utoA:
14.67
2hdnB-5utoA:
12.99
2hdnD-5utoA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_D_TACD2888_1
(ELONGATION FACTOR
EF-TU)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 5 SER A  55
SER A  56
ASP A  33
PRO A  60
 None
 1.40A 2hdnB-5utoA:
undetectable
2hdnC-5utoA:
undetectable
2hdnD-5utoA:
4.0		 2hdnB-5utoA:
12.99
2hdnC-5utoA:
14.67
2hdnD-5utoA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A 235
GLU A 262
ILE A  46
ALA A 268
GLU A 239
 None
 0.99A 2vdvE-5utoA:
undetectable		 2vdvE-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 11 GLY A 235
GLU A 262
ILE A  46
ALA A 268
GLU A 239
 None
 0.99A 2vdvF-5utoA:
undetectable		 2vdvF-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 7 ALA A 268
ASN A 167
PRO A  60
ALA A 269
 None
 0.98A 2zgwA-5utoA:
undetectable		 2zgwA-5utoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 6 ALA A 268
ASN A 167
PRO A  60
ALA A 269
 None
 1.01A 2zgwB-5utoA:
undetectable		 2zgwB-5utoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 8 VAL A  30
GLY A 264
TYR A  12
HIS A 270
 None
None
None
PLM  A 301 (-3.5A)
 0.93A 3af0A-5utoA:
undetectable		 3af0A-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 6 MET A   6
ARG A  78
PRO A  65
GLY A  68
 None
 1.45A 3aqiA-5utoA:
3.1		 3aqiA-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A 235
GLU A 262
ILE A  46
ALA A 268
GLU A 239
 None
 0.93A 3ckkA-5utoA:
2.1		 3ckkA-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 GLY A 126
SER A  11
SER A 261
ILE A 285
LEU A 130
 None
 1.28A 3iv6D-5utoA:
undetectable		 3iv6D-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 9 ALA A 122
VAL A 267
ILE A 198
LEU A 168
ILE A  94
 PLM  A 301 ( 4.5A)
PLM  A 301 (-4.3A)
None
None
PLM  A 301 (-4.2A)
 1.29A 3jw3B-5utoA:
undetectable		 3jw3B-5utoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N6P_A_JMSA713_1
(LACTOTRANSFERRIN)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 4 HIS A 270
ALA A 268
VAL A 267
GLU A  40
 PLM  A 301 (-3.5A)
None
PLM  A 301 (-4.3A)
None
 1.48A 4n6pA-5utoA:
undetectable		 4n6pA-5utoA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 12 LEU A 168
PHE A 263
GLU A  40
THR A  10
ALA A 122
 None
PLM  A 301 ( 4.8A)
None
None
PLM  A 301 ( 4.5A)
 1.23A 5ieoA-5utoA:
undetectable		 5ieoA-5utoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 11 VAL A 222
ASP A 224
TYR A 280
TYR A 256
LEU A 230
 None
 1.40A 5jh7B-5utoA:
2.2		 5jh7B-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		5 / 11 VAL A 222
ASP A 224
TYR A 280
TYR A 256
LEU A 230
 None
 1.48A 5jh7D-5utoA:
2.5		 5jh7D-5utoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5uto EDD DOMAIN PROTEIN,
DEGV FAMILY
(Staphylococcus
aureus) 		4 / 5 ILE A 233
LEU A 191
HIS A 270
VAL A 267
 PLM  A 301 (-4.1A)
None
PLM  A 301 (-3.5A)
PLM  A 301 (-4.3A)
 1.19A 5jmnB-5utoA:
undetectable		 5jmnB-5utoA:
5.26