SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 12 LEU A 124
MET A 121
GLY A  38
GLY A  39
LEU A 173
 7DZ  A 401 (-4.1A)
7DZ  A 401 (-4.3A)
7DZ  A 401 (-3.3A)
None
None
 0.83A 2uvnA-5uu1A:
undetectable		 2uvnA-5uu1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 9 VAL A  59
VAL A  60
ILE A  35
GLY A  32
ALA A  56
 7DZ  A 401 (-4.6A)
None
7DZ  A 401 ( 4.9A)
None
None
 0.94A 4fwdA-5uu1A:
undetectable		 4fwdA-5uu1A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 12 SER A 190
TYR A 162
ALA A  81
ASP A 152
GLY A  99
 None
 1.19A 4j7xA-5uu1A:
undetectable		 4j7xA-5uu1A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 8 GLY A  39
ASP A 127
ASN A 171
LEU A 173
ASP A 186
 None
None
7DZ  A 401 ( 4.7A)
None
7DZ  A 401 ( 4.8A)
 0.53A 4ogrA-5uu1A:
21.7		 4ogrA-5uu1A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		4 / 6 LEU A 248
LYS A 264
LEU A 268
LEU A 292
 None
 1.11A 5yvnA-5uu1A:
undetectable		 5yvnA-5uu1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 9 LEU A 172
GLY A 147
LEU A 146
GLN A 145
VAL A 153
 None
 1.27A 6czmA-5uu1A:
undetectable
6czmB-5uu1A:
undetectable		 6czmA-5uu1A:
25.94
6czmB-5uu1A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 9 LEU A 172
GLY A 147
LEU A 146
GLN A 145
VAL A 153
 None
 1.30A 6czmB-5uu1A:
undetectable
6czmC-5uu1A:
undetectable		 6czmB-5uu1A:
25.94
6czmC-5uu1A:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5uu1 SERINE/THREONINE-PRO
TEIN KINASE VRK2
(Homo
sapiens) 		5 / 10 LEU A 172
GLY A 147
LEU A 146
GLN A 145
VAL A 153
 None
 1.25A 6czmE-5uu1A:
undetectable
6czmF-5uu1A:
undetectable		 6czmE-5uu1A:
25.94
6czmF-5uu1A:
25.94