SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uuu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 7 VAL A 255
MET A 274
ARG A 316
LEU A 324
 None
MES  A 604 (-3.9A)
None
None
 0.88A 1iepB-5uuuA:
21.1		 1iepB-5uuuA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
LYS A 220
GLU A 239
LEU A 243
VAL A 255
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
None
None
None
 0.89A 1t46A-5uuuA:
21.8		 1t46A-5uuuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 PHE A 171
LEU A  47
PHE A 165
SER A  60
 None
 1.19A 1wrkB-5uuuA:
undetectable		 1wrkB-5uuuA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 218
ASP A 317
LYS A 319
ALA A 321
ASN A 322
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
None
None
None
QRW  A 601 (-3.7A)
 0.85A 2fumA-5uuuA:
27.3		 2fumA-5uuuA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 LEU A 377
ILE A 323
GLY A 304
HIS A 309
 None
 0.89A 2otfA-5uuuA:
undetectable		 2otfA-5uuuA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 9 VAL A 205
ALA A 218
LEU A 271
MET A 274
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 0.78A 2xp2A-5uuuA:
22.5		 2xp2A-5uuuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
None
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 1.14A 2y7jA-5uuuA:
30.6		 2y7jA-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 ILE A 197
ARG A 199
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
None
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 1.28A 2y7jA-5uuuA:
30.6		 2y7jA-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 0.68A 2y7jB-5uuuA:
31.0		 2y7jB-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 0.85A 2y7jB-5uuuA:
31.0		 2y7jB-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 0.95A 2y7jC-5uuuA:
30.6		 2y7jC-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 0.67A 2y7jC-5uuuA:
30.6		 2y7jC-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
ALA A 218
LEU A 273
MET A 274
GLY A 276
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
 1.02A 2y7jD-5uuuA:
30.4		 2y7jD-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
LEU A 273
MET A 274
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
 0.57A 2y7jD-5uuuA:
30.4		 2y7jD-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 10 ILE A 197
VAL A 205
ALA A 218
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
MES  A 604 (-3.9A)
None
None
 0.74A 2y7jD-5uuuA:
30.4		 2y7jD-5uuuA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 ALA A 218
LYS A 220
GLU A 239
VAL A 255
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
MES  A 604 (-3.9A)
None
None
 0.81A 2zvaA-5uuuA:
24.8		 2zvaA-5uuuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 10 ALA A 218
LYS A 220
VAL A 255
LEU A 271
LEU A 273
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
QRW  A 601 ( 4.9A)
None
MES  A 604 (-3.9A)
None
None
 0.70A 3aoxA-5uuuA:
21.8		 3aoxA-5uuuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 ALA A 218
VAL A 255
LEU A 271
LEU A 273
MET A 274
GLY A 276
LEU A 324
 QRW  A 601 (-3.4A)
None
QRW  A 601 ( 4.9A)
None
MES  A 604 (-3.9A)
None
None
 0.97A 3aoxA-5uuuA:
21.8		 3aoxA-5uuuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 8 GLU A 181
SER A 514
GLN A 518
VAL A 525
 None
 1.23A 3b9lA-5uuuA:
undetectable		 3b9lA-5uuuA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 TYR A 506
GLU A 239
ASP A 317
 None
QRW  A 601 (-3.9A)
None
 0.87A 3bxoB-5uuuA:
undetectable		 3bxoB-5uuuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 ALA A 218
LYS A 220
GLU A 239
LEU A 243
LEU A 273
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
None
 0.49A 3hecA-5uuuA:
22.9		 3hecA-5uuuA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 7 ASP A 250
TYR A  65
GLN A  61
GLU A 515
 None
 1.07A 3l2vA-5uuuA:
undetectable		 3l2vA-5uuuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 8 ALA A 218
LYS A 220
GLU A 239
LEU A 273
MET A 274
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
MES  A 604 (-3.9A)
 0.77A 3lfaA-5uuuA:
23.1		 3lfaA-5uuuA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 ALA A 218
LYS A 220
VAL A 255
MET A 274
LEU A 324
SER A 334
ASP A 335
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 ( 3.7A)
QRW  A 601 (-3.7A)
 0.95A 3miyA-5uuuA:
22.1		 3miyA-5uuuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 LYS A 220
VAL A 255
MET A 274
GLY A 277
LEU A 324
SER A 334
ASP A 335
 QRW  A 601 (-3.0A)
None
MES  A 604 (-3.9A)
None
None
QRW  A 601 ( 3.7A)
QRW  A 601 (-3.7A)
 0.96A 3miyA-5uuuA:
22.1		 3miyA-5uuuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 ALA A 218
LYS A 220
MET A 274
LEU A 324
SER A 334
 QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
MES  A 604 (-3.9A)
None
QRW  A 601 ( 3.7A)
 0.72A 3miyB-5uuuA:
22.0		 3miyB-5uuuA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 424
VAL A 447
HIS A 307
ILE A 254
LEU A 318
 None
 1.26A 3sp9B-5uuuA:
undetectable		 3sp9B-5uuuA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 271
MET A 274
ASP A 278
 QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
 0.19A 3v5wA-5uuuA:
54.6		 3v5wA-5uuuA:
95.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 218
LEU A 271
LEU A 273
MET A 274
ASP A 278
ASP A 335
 QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
None
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 0.74A 3zbfA-5uuuA:
23.4		 3zbfA-5uuuA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 12 ALA A 218
LEU A 273
MET A 274
ASP A 278
LEU A 324
ASP A 335
 QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
None
QRW  A 601 (-3.7A)
 0.85A 3zbfA-5uuuA:
23.4		 3zbfA-5uuuA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 VAL A 205
ALA A 218
LYS A 220
GLU A 239
VAL A 255
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 (-3.9A)
None
None
None
 0.72A 4ag8A-5uuuA:
21.8		 4ag8A-5uuuA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 VAL A 205
ILE A 254
MET A 274
ILE A 333
 QRW  A 601 (-4.7A)
None
MES  A 604 (-3.9A)
None
 0.62A 4c8bA-5uuuA:
21.9		 4c8bA-5uuuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 12 VAL A 205
ALA A 218
ASP A 278
ASP A 317
LYS A 319
ASN A 322
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
None
None
None
None
QRW  A 601 (-3.7A)
 0.69A 4i41A-5uuuA:
28.2		 4i41A-5uuuA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 11 VAL A 205
ALA A 218
LEU A 271
ASP A 278
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
None
None
 0.56A 4iaaA-5uuuA:
28.2		 4iaaA-5uuuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 11 VAL A 205
ALA A 218
LYS A 220
LEU A 271
ASP A 278
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 ( 4.9A)
None
QRW  A 601 (-3.7A)
 0.64A 4iaaA-5uuuA:
28.2		 4iaaA-5uuuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LEU A 243
MET A 257
ASP A 278
 None
 0.83A 4j7xB-5uuuA:
undetectable		 4j7xB-5uuuA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 11 GLY A 198
VAL A 205
ALA A 218
LYS A 220
ASN A 322
LEU A 324
ASP A 335
 QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
None
QRW  A 601 (-3.7A)
 0.89A 4o0sA-5uuuA:
30.6		 4o0sA-5uuuA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 PHE A 453
PHE A 452
LEU A 429
PRO A 390
 None
 1.25A 4o8zA-5uuuA:
undetectable		 4o8zA-5uuuA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 12 GLY A 198
GLY A 200
GLY A 203
VAL A 205
ALA A 218
VAL A 255
LEU A 324
 QRW  A 601 ( 4.5A)
QRW  A 601 (-3.6A)
QRW  A 601 (-4.2A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
None
 0.57A 4otiA-5uuuA:
33.5		 4otiA-5uuuA:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 GLU A 537
THR A 533
GLN A 176
LEU A  67
 None
 1.14A 4qzuC-5uuuA:
undetectable		 4qzuC-5uuuA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 197
ALA A 218
LYS A 220
PHE A 269
LEU A 273
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
None
None
 0.57A 4rz7A-5uuuA:
12.2		 4rz7A-5uuuA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 ILE A 197
ALA A 218
PHE A 269
LEU A 273
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
None
None
 0.60A 4rz7A-5uuuA:
12.2		 4rz7A-5uuuA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		8 / 11 GLY A 200
VAL A 205
ALA A 218
MET A 274
GLY A 277
ASN A 322
LEU A 324
ASP A 335
 QRW  A 601 (-3.6A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
MES  A 604 (-3.9A)
None
None
None
QRW  A 601 (-3.7A)
 0.68A 4u5jA-5uuuA:
24.9		 4u5jA-5uuuA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 8 ALA A 218
ASN A 275
LEU A 324
SER A 334
 QRW  A 601 (-3.4A)
MES  A 604 (-3.8A)
None
QRW  A 601 ( 3.7A)
 0.58A 4wboB-5uuuA:
37.3		 4wboB-5uuuA:
34.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 273
MET A 274
LEU A 324
 QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
 0.41A 4xoyA-5uuuA:
25.5		 4xoyA-5uuuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 6 ALA A 218
LEU A 273
MET A 274
LEU A 324
 QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
None
 0.39A 4xp3A-5uuuA:
26.3		 4xp3A-5uuuA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 LYS A 215
GLY A 214
ASP A 190
TYR A 259
ILE A 270
 None
 1.20A 4ypeA-5uuuA:
undetectable		 4ypeA-5uuuA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 11 LYS A 215
GLY A 214
ASP A 190
TYR A 259
ILE A 270
 None
 1.28A 4ypeB-5uuuA:
undetectable		 4ypeB-5uuuA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		6 / 9 VAL A 205
ALA A 218
LEU A 271
MET A 274
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
QRW  A 601 (-3.7A)
 0.84A 5aaaA-5uuuA:
22.6		 5aaaA-5uuuA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 VAL A 205
ALA A 218
LEU A 271
MET A 274
GLY A 277
LEU A 324
ASP A 335
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
None
QRW  A 601 (-3.7A)
 0.88A 5aacA-5uuuA:
22.3		 5aacA-5uuuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		7 / 10 VAL A 205
ALA A 218
LYS A 220
LEU A 271
MET A 274
GLY A 277
LEU A 324
 QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
QRW  A 601 (-3.0A)
QRW  A 601 ( 4.9A)
MES  A 604 (-3.9A)
None
None
 0.96A 5aacA-5uuuA:
22.3		 5aacA-5uuuA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 LEU A 271
ASP A 265
THR A 263
ILE A 241
PHE A 269
 QRW  A 601 ( 4.9A)
None
None
None
None
 1.46A 5dlvB-5uuuA:
undetectable		 5dlvB-5uuuA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 PHE A 453
LEU A 425
GLY A 378
ILE A 302
 None
 0.88A 5ik1A-5uuuA:
undetectable		 5ik1A-5uuuA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 VAL A 521
SER A 514
MET A 257
 None
 0.81A 5ikqA-5uuuA:
undetectable		 5ikqA-5uuuA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 7 GLY A 198
GLY A 200
VAL A 205
LYS A 220
LEU A 222
 QRW  A 601 ( 4.5A)
QRW  A 601 (-3.6A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.0A)
QRW  A 601 (-4.3A)
 0.63A 5izjA-5uuuA:
29.8		 5izjA-5uuuA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 ILE A 197
GLY A 198
VAL A 205
ALA A 218
MET A 274
 QRW  A 601 (-4.7A)
QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
MES  A 604 (-3.9A)
 0.60A 5lw1B-5uuuA:
23.5		 5lw1B-5uuuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 10 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
 0.64A 5lw1E-5uuuA:
16.3		 5lw1E-5uuuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 9 GLY A 198
VAL A 205
ALA A 218
LEU A 273
MET A 274
 QRW  A 601 ( 4.5A)
QRW  A 601 (-4.7A)
QRW  A 601 (-3.4A)
None
MES  A 604 (-3.9A)
 0.69A 5lw1H-5uuuA:
23.4		 5lw1H-5uuuA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 MET A 380
LEU A 381
ILE A 333
LEU A 305
LEU A 279
 None
 1.21A 5toaB-5uuuA:
undetectable		 5toaB-5uuuA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 4 VAL A 255
LEU A 273
ASN A 322
ASP A 335
 None
None
None
QRW  A 601 (-3.7A)
 1.10A 5vcyA-5uuuA:
25.2		 5vcyA-5uuuA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_1
(CARNOSINE
N-METHYLTRANSFERASE)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		4 / 5 GLN A 430
ARG A 435
GLU A 426
ASP A 415
 None
 1.33A 5yf0A-5uuuA:
0.4		 5yf0A-5uuuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		3 / 3 LYS A 170
LEU A  34
ASP A 534
 None
 0.91A 5zv2A-5uuuA:
21.3		 5zv2A-5uuuA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens) 		5 / 12 VAL A 180
ILE A  32
VAL A 521
LEU A  67
LEU A  63
 None
 0.97A 6ajiA-5uuuA:
undetectable		 6ajiA-5uuuA:
20.49