SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uuw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 ALA A 356
LEU A 321
LEU A  11
ILE A 461
LEU A  18
 None
 1.40A 1ereD-5uuwA:
undetectable		 1ereD-5uuwA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 6 ILE A 344
LYS A 352
ALA A 356
VAL A 361
 None
 1.01A 1hk1A-5uuwA:
undetectable		 1hk1A-5uuwA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 ARG A 440
THR A  34
VAL A  32
 None
 0.95A 1hxbA-5uuwA:
undetectable		 1hxbA-5uuwA:
14.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 ASN A 280
GLY A 303
CYH A 308
THR A 310
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
IMP  A 501 ( 3.2A)
 0.38A 1jr1A-5uuwA:
50.7		 1jr1A-5uuwA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 ASP A 251
GLY A 303
CYH A 308
THR A 310
GLY A 392
 None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
IMP  A 501 ( 3.2A)
 0.72A 1jr1A-5uuwA:
50.7		 1jr1A-5uuwA:
31.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 8 ASN A 280
GLY A 303
THR A 310
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
8N1  A 502 (-3.9A)
IMP  A 501 ( 3.2A)
 0.29A 1jr1B-5uuwA:
50.5		 1jr1B-5uuwA:
31.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 8 ASN A 280
ILE A 302
GLY A 303
CYH A 308
GLY A 392
 IMP  A 501 (-4.1A)
None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
IMP  A 501 ( 3.2A)
 0.38A 1me7A-5uuwA:
47.3		 1me7A-5uuwA:
29.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 LEU A 290
GLY A 279
THR A 252
ASP A 262
VAL A 229
 None
None
8N1  A 502 (-2.9A)
None
None
 1.19A 1phgA-5uuwA:
undetectable		 1phgA-5uuwA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 GLY A 301
ARG A 311
ASP A 326
CYH A 327
ASP A 341
 None
None
None
None
IMP  A 501 (-2.4A)
 1.05A 2br4C-5uuwA:
undetectable		 2br4C-5uuwA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 ARG A 440
VAL A 360
THR A  34
 None
 0.53A 2nmzA-5uuwA:
undetectable		 2nmzA-5uuwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 ARG A 440
THR A  34
VAL A  32
 None
 0.97A 2q64A-5uuwA:
undetectable		 2q64A-5uuwA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 501 (-3.9A)
IMP  A 501 ( 3.2A)
None
 0.97A 2qmmA-5uuwA:
undetectable		 2qmmA-5uuwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 LEU A 363
ILE A 344
GLY A 343
GLY A 305
SER A  48
 None
None
IMP  A 501 (-3.9A)
IMP  A 501 ( 3.2A)
None
 0.96A 2qmmA-5uuwA:
undetectable
2qmmB-5uuwA:
undetectable		 2qmmA-5uuwA:
23.46
2qmmB-5uuwA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 4 LYS A 386
ALA A 368
PHE A 367
GLY A 364
 None
None
None
IMP  A 501 (-3.7A)
 1.38A 2rddA-5uuwA:
undetectable		 2rddA-5uuwA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_B_ECNB1406_1
(CYTOCHROME P450 130)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 11 MET A  59
MET A  63
THR A  55
GLY A  50
VAL A 249
 None
 1.27A 2uvnB-5uuwA:
undetectable		 2uvnB-5uuwA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		3 / 3 ARG A 440
VAL A 360
THR A  34
 None
 0.71A 3k4vD-5uuwA:
undetectable		 3k4vD-5uuwA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 GLN A  81
GLY A  70
GLY A  50
ALA A 226
GLY A 224
 None
 1.06A 3tegA-5uuwA:
undetectable		 3tegA-5uuwA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ASP A 251
ILE A 339
GLY A  50
ALA A  49
VAL A 249
 None
None
None
IMP  A 501 (-3.2A)
None
 1.06A 3uq6B-5uuwA:
2.2		 3uq6B-5uuwA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ASP A 251
ILE A 339
GLY A  50
ALA A  49
VAL A 249
 None
None
None
IMP  A 501 (-3.2A)
None
 1.08A 3vaqB-5uuwA:
undetectable		 3vaqB-5uuwA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 9 LEU A 454
LEU A  69
ILE A  47
MET A 350
ILE A 339
 None
 1.21A 3zosB-5uuwA:
undetectable		 3zosB-5uuwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 4 SER A 306
TYR A 388
GLY A 342
PRO A 304
 IMP  A 501 (-2.8A)
IMP  A 501 (-4.7A)
IMP  A 501 (-3.1A)
None
 1.48A 4e3aA-5uuwA:
undetectable		 4e3aA-5uuwA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		4 / 4 SER A 306
TYR A 388
GLY A 343
PRO A 304
 IMP  A 501 (-2.8A)
IMP  A 501 (-4.7A)
IMP  A 501 (-3.9A)
None
 1.33A 4e3aA-5uuwA:
undetectable		 4e3aA-5uuwA:
27.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 8 ASN A 280
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 501 (-4.1A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
None
IMP  A 501 ( 3.2A)
 0.23A 4fo4A-5uuwA:
56.3		 4fo4A-5uuwA:
63.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		6 / 8 ASN A 280
GLY A 303
CYH A 308
THR A 310
MET A 391
GLY A 392
 IMP  A 501 (-4.1A)
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
None
IMP  A 501 ( 3.2A)
 0.24A 4fo4B-5uuwA:
52.6		 4fo4B-5uuwA:
63.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		7 / 9 ASP A 251
ASN A 280
ILE A 302
GLY A 303
CYH A 308
THR A 310
ASP A 341
 None
IMP  A 501 (-4.1A)
None
K  A 507 (-4.8A)
IMP  A 501 ( 3.2A)
8N1  A 502 (-3.9A)
IMP  A 501 (-2.4A)
 0.38A 4fxsA-5uuwA:
55.2		 4fxsA-5uuwA:
45.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A 295
GLY A 294
ILE A 277
ASN A 275
GLY A 279
 None
 0.98A 4obwB-5uuwA:
undetectable		 4obwB-5uuwA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A 295
VAL A 264
LEU A  40
ILE A  47
MET A 362
 None
None
None
None
IMP  A 501 ( 3.7A)
 1.19A 5hv1A-5uuwA:
2.1		 5hv1A-5uuwA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ILE A 302
ILE A 276
ALA A 295
LEU A 290
ALA A 289
 None
 1.17A 5oy02-5uuwA:
undetectable		 5oy02-5uuwA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5uuw INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Bacillus
anthracis) 		5 / 12 ALA A  49
GLY A 342
GLY A  68
LEU A  40
LEU A  42
 IMP  A 501 (-3.2A)
IMP  A 501 (-3.1A)
None
None
None
 1.02A 5wwsA-5uuwA:
undetectable		 5wwsA-5uuwA:
21.85