SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 5 ASP A 997
ILE A 867
ILE A1000
GLY A 963
 None
 0.85A 3bufA-5uv4A:
undetectable		 3bufA-5uv4A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		5 / 11 VAL A 955
ALA A1020
ILE A 867
LEU A 844
ILE A 956
 None
 1.01A 3clbA-5uv4A:
undetectable		 3clbA-5uv4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		5 / 12 VAL A 955
ALA A1020
ILE A 867
LEU A 844
ILE A 956
 None
 0.99A 3clbC-5uv4A:
undetectable		 3clbC-5uv4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		5 / 10 VAL A 955
ALA A1020
ILE A 867
LEU A 844
ILE A 956
 None
 1.01A 3hbbA-5uv4A:
undetectable		 3hbbA-5uv4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		5 / 11 VAL A 955
ALA A1020
ILE A 867
LEU A 844
ILE A 956
 None
 0.99A 3hbbC-5uv4A:
undetectable		 3hbbC-5uv4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 7 LEU A 759
LEU A 786
SER A 775
THR A 906
 None
None
ANP  A1101 (-2.6A)
MG  A1102 ( 4.6A)
 0.99A 3lm8B-5uv4A:
undetectable
3lm8D-5uv4A:
undetectable		 3lm8B-5uv4A:
21.05
3lm8D-5uv4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		5 / 12 THR A 787
SER A 836
SER A 775
LEU A 791
PHE A 802
 None
None
ANP  A1101 (-2.6A)
None
None
 1.42A 3u9fH-5uv4A:
undetectable
3u9fI-5uv4A:
undetectable		 3u9fH-5uv4A:
24.39
3u9fI-5uv4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		5 / 10 THR A 787
SER A 836
SER A 775
LEU A 791
PHE A 802
 None
None
ANP  A1101 (-2.6A)
None
None
 1.45A 3u9fI-5uv4A:
undetectable		 3u9fI-5uv4A:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 5 LEU A 986
ASP A 981
ARG A 984
ILE A1024
 None
 1.49A 4mwrA-5uv4A:
undetectable		 4mwrA-5uv4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 8 VAL A1033
HIS A 886
ASP A 949
HIS A 879
 None
 0.89A 5a5zA-5uv4A:
undetectable		 5a5zA-5uv4A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 6 SER A 909
ASP A 837
ARG A 821
GLY A 822
 None
 0.95A 5cdnC-5uv4A:
2.3
5cdnD-5uv4A:
undetectable		 5cdnC-5uv4A:
21.95
5cdnD-5uv4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 6 SER A 909
ASP A 837
ARG A 821
GLY A 822
 None
 0.93A 5cdnT-5uv4A:
2.3
5cdnU-5uv4A:
undetectable		 5cdnT-5uv4A:
21.95
5cdnU-5uv4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		3 / 3 THR A 842
THR A 846
ARG A 854
 None
 1.03A 5wm2A-5uv4A:
undetectable		 5wm2A-5uv4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5uv4 PUTATIVE
LEUCINE-RICH REPEAT
PROTEIN KINASE
FAMILY PROTEIN
(Zea
mays) 		4 / 8 GLY A 822
LEU A 809
GLY A 810
LEU A 820
 None
 0.84A 6mdqA-5uv4A:
undetectable		 6mdqA-5uv4A:
14.09