SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uve'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 8 SER A 123
LEU A 270
LEU A  39
GLU A  35
 None
 0.77A 2j2pA-5uveA:
undetectable
2j2pB-5uveA:
undetectable		 2j2pA-5uveA:
22.65
2j2pB-5uveA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		3 / 3 LYS A 158
ARG A 134
VAL A 137
 None
 1.07A 2r2vC-5uveA:
undetectable
2r2vD-5uveA:
undetectable		 2r2vC-5uveA:
8.27
2r2vD-5uveA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 8 PHE A 167
LEU A 174
PHE A 177
GLY A 130
 None
 0.94A 2vdbA-5uveA:
undetectable		 2vdbA-5uveA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 8 TRP A 119
ILE A 117
ILE A  77
TYR A  78
 None
 1.06A 2zmaA-5uveA:
undetectable		 2zmaA-5uveA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		5 / 12 LEU A 263
ALA A  49
VAL A  26
ILE A 259
THR A  54
 None
 1.08A 3czhB-5uveA:
undetectable		 3czhB-5uveA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 8 ILE A  42
THR A 274
LEU A 278
ALA A 125
 None
 0.63A 3hrdA-5uveA:
undetectable
3hrdB-5uveA:
undetectable		 3hrdA-5uveA:
22.97
3hrdB-5uveA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 8 ASP A 234
GLN A 239
PRO A 240
GLN A 243
 None
 1.13A 3oyaA-5uveA:
undetectable		 3oyaA-5uveA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 7 ARG A 249
GLY A  40
ILE A  43
VAL A  66
 None
 0.75A 3ufnB-5uveA:
undetectable		 3ufnB-5uveA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 5 LEU A 190
ILE A 131
ALA A 163
PHE A 167
 None
 1.08A 4dc3B-5uveA:
undetectable		 4dc3B-5uveA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 6 VAL A  26
VAL A 252
ILE A 248
LEU A 263
 None
 0.99A 4l1wB-5uveA:
undetectable		 4l1wB-5uveA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		4 / 7 ASN A  24
VAL A 252
GLU A 251
ARG A 249
 None
 0.94A 4mv7A-5uveA:
2.2		 4mv7A-5uveA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		5 / 12 ASP A 277
VAL A 231
LEU A 229
ILE A 224
GLY A 223
 None
 1.11A 4y8wA-5uveA:
undetectable		 4y8wA-5uveA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		5 / 12 ASP A 277
VAL A 231
LEU A 229
ILE A 224
GLY A 223
 None
 1.11A 4y8wB-5uveA:
undetectable		 4y8wB-5uveA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		5 / 12 GLY A 156
ILE A 224
GLY A 219
GLY A 130
LEU A 161
 None
 1.09A 5eqbA-5uveA:
undetectable		 5eqbA-5uveA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		3 / 3 ASP A 234
SER A 147
TYR A 181
 None
 0.84A 5glmA-5uveA:
undetectable		 5glmA-5uveA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		3 / 3 GLY A 156
GLY A 157
GLN A 189
 None
 0.45A 5imsA-5uveA:
undetectable		 5imsA-5uveA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		3 / 3 GLY A 219
THR A 121
PRO A 244
 None
 0.56A 5v5zA-5uveA:
undetectable		 5v5zA-5uveA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 5uve SUBSTRATE-BINDING
REGION OF ABC-TYPE
GLYCINE BETAINE
TRANSPORT SYSTEM
(Brucella
abortus) 		3 / 3 VAL A 118
TYR A 112
GLU A 260
 None
 0.71A 5zmqD-5uveA:
undetectable
5zmqE-5uveA:
undetectable		 5zmqD-5uveA:
21.80
5zmqE-5uveA:
13.16