SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		4 / 6 PRO A 424
ASP A 481
ASP A 485
TRP A 482
 None
 1.39A 1hpkA-5uvgA:
undetectable		 1hpkA-5uvgA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		5 / 12 ALA A 151
LEU A 362
GLN A 363
VAL A 365
ILE A 385
 None
 1.18A 3datA-5uvgA:
undetectable		 3datA-5uvgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		4 / 6 PHE A 439
ALA A 458
THR A 460
LEU A 528
 None
 0.96A 3t3zA-5uvgA:
undetectable		 3t3zA-5uvgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		4 / 6 PHE A 439
ALA A 458
THR A 460
LEU A 528
 None
 0.98A 3t3zB-5uvgA:
undetectable		 3t3zB-5uvgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		4 / 5 PHE A 439
ALA A 458
THR A 460
LEU A 528
 None
 1.05A 3t3zC-5uvgA:
undetectable		 3t3zC-5uvgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		4 / 6 PHE A 439
ALA A 458
THR A 460
LEU A 528
 None
 1.00A 3t3zD-5uvgA:
undetectable		 3t3zD-5uvgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		5 / 12 HIS A 461
ASP A 510
ASN A 512
ILE A 606
HIS A 639
 None
 0.24A 5dv4A-5uvgA:
21.0		 5dv4A-5uvgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 5uvg SPHINGOMYELIN
PHOSPHODIESTERASE
3,SPHINGOMYELIN
PHOSPHODIESTERASE 3
(Homo
sapiens) 		4 / 5 ILE A 630
SER A 350
ALA A 162
LEU A 360
 None
 0.91A 6dwnA-5uvgA:
undetectable		 6dwnA-5uvgA:
11.59