SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.89A 1fm9A-5uvmA:
undetectable		 1fm9A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.89A 1fm9A-5uvmA:
undetectable		 1fm9A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.93A 1k74A-5uvmA:
undetectable		 1k74A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.89A 1k74A-5uvmA:
undetectable		 1k74A-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ALA A  67
VAL A  71
ALA A  68
HIS A  65
 None
 1.01A 1q23A-5uvmA:
undetectable		 1q23A-5uvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 4 ALA A  67
VAL A  71
ALA A  68
HIS A  65
 None
 1.02A 1q23K-5uvmA:
undetectable		 1q23K-5uvmA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.96A 1xiuB-5uvmA:
undetectable		 1xiuB-5uvmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.86A 1xiuB-5uvmA:
undetectable		 1xiuB-5uvmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.92A 1xlsA-5uvmA:
undetectable		 1xlsA-5uvmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.91A 1xlsB-5uvmA:
undetectable		 1xlsB-5uvmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.91A 1xlsC-5uvmA:
undetectable		 1xlsC-5uvmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.92A 1xlsD-5uvmA:
undetectable		 1xlsD-5uvmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 11 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 1.00A 2aclE-5uvmA:
undetectable		 2aclE-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.96A 2aclG-5uvmA:
undetectable		 2aclG-5uvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 5 ALA A  58
GLN A  59
ILE A  60
ARG A  24
 None
 1.18A 2z0aA-5uvmA:
undetectable		 2z0aA-5uvmA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A  77
LEU A  75
VAL A  39
GLY A 105
 None
 0.82A 3dcjB-5uvmA:
undetectable		 3dcjB-5uvmA:
20.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		7 / 10 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
HIS A 100
HIS A 102
 None
UNX  A 209 ( 4.4A)
UNX  A 213 ( 3.0A)
UNX  A 217 ( 3.8A)
None
UNX  A 202 ( 3.6A)
UNX  A 203 ( 4.5A)
 0.67A 3o1cA-5uvmA:
20.1		 3o1cA-5uvmA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		7 / 10 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
HIS A 100
HIS A 102
 None
UNX  A 209 ( 4.4A)
UNX  A 213 ( 3.0A)
UNX  A 217 ( 3.8A)
None
UNX  A 202 ( 3.6A)
UNX  A 203 ( 4.5A)
 0.68A 3o1xA-5uvmA:
20.0		 3o1xA-5uvmA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		7 / 10 PHE A   6
ILE A   9
ASP A  30
ILE A  31
LEU A  40
HIS A 100
HIS A 102
 None
UNX  A 209 ( 4.4A)
UNX  A 213 ( 3.0A)
UNX  A 217 ( 3.8A)
None
UNX  A 202 ( 3.6A)
UNX  A 203 ( 4.5A)
 0.61A 3qgzA-5uvmA:
20.1		 3qgzA-5uvmA:
34.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 8 ASN A  87
ALA A  92
GLN A  94
HIS A 100
HIS A 102
 UNX  A 203 ( 4.2A)
None
None
UNX  A 202 ( 3.6A)
UNX  A 203 ( 4.5A)
 1.18A 5km8A-5uvmA:
16.4
5km8B-5uvmA:
20.0		 5km8A-5uvmA:
33.33
5km8B-5uvmA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		7 / 12 PHE A   6
ILE A   9
ASP A  30
LEU A  40
VAL A  96
HIS A 100
HIS A 102
 None
UNX  A 209 ( 4.4A)
UNX  A 213 ( 3.0A)
None
None
UNX  A 202 ( 3.6A)
UNX  A 203 ( 4.5A)
 0.39A 5km9B-5uvmA:
20.1		 5km9B-5uvmA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		7 / 12 PHE A   6
ILE A   9
LEU A  14
LEU A  40
VAL A  96
HIS A 100
HIS A 102
 None
UNX  A 209 ( 4.4A)
None
None
None
UNX  A 202 ( 3.6A)
UNX  A 203 ( 4.5A)
 0.68A 5km9B-5uvmA:
20.1		 5km9B-5uvmA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.91A 5z12B-5uvmA:
undetectable		 5z12B-5uvmA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
VAL A  50
 None
 0.87A 5z12B-5uvmA:
undetectable		 5z12B-5uvmA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uvm HISTIDINE TRIAD
(HIT) PROTEIN
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A  64
ALA A  67
ALA A  68
LEU A 103
ALA A  27
 None
 0.88A 6a60D-5uvmA:
undetectable		 6a60D-5uvmA:
20.27