SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 148
LEU A 167
THR A 197
PRO A 110
ILE A 146
 None
None
MLY  A 196 ( 3.7A)
None
None
 1.06A 1cd2A-5uvrA:
undetectable		 1cd2A-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		3 / 3 GLN A 138
ILE A 142
TYR A 141
 None
 0.65A 1vifA-5uvrA:
undetectable		 1vifA-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 148
LEU A 167
THR A 197
PRO A 110
ILE A 146
 None
None
MLY  A 196 ( 3.7A)
None
None
 1.03A 2cd2A-5uvrA:
undetectable		 2cd2A-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 205
GLY A 204
ILE A 142
GLN A 138
 None
 1.18A 4ma8C-5uvrA:
undetectable		 4ma8C-5uvrA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		4 / 6 ILE A 116
LEU A 121
PHE A 160
THR A 172
 None
None
None
MLY  A 196 ( 4.3A)
 1.06A 5b1aN-5uvrA:
undetectable
5b1aW-5uvrA:
undetectable		 5b1aN-5uvrA:
undetectable
5b1aW-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		4 / 5 PHE A 127
GLY A 122
ILE A 148
LEU A 121
 None
 0.80A 5dzkd-5uvrA:
undetectable
5dzkk-5uvrA:
undetectable
5dzky-5uvrA:
undetectable		 5dzkd-5uvrA:
undetectable
5dzkk-5uvrA:
undetectable
5dzky-5uvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uvr PILO PROTEIN
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 173
TYR A 141
PRO A 145
ILE A 146
 None
None
MLY  A 196 ( 4.4A)
None
 1.17A 5esgA-5uvrA:
undetectable		 5esgA-5uvrA:
11.37