SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uw2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD
(Escherichia
coli) 		5 / 9 LEU A 128
ILE A  93
VAL A  58
GLY A  66
LEU A  99
 None
 1.02A 1e7aB-5uw2A:
undetectable		 1e7aB-5uw2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD
(Escherichia
coli) 		5 / 12 LEU A 128
ILE A  93
VAL A  58
GLY A  66
LEU A  99
 None
 1.11A 2bxeB-5uw2A:
undetectable		 2bxeB-5uw2A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD
(Escherichia
coli) 		4 / 6 PHE A  46
LEU A  84
ALA A 113
LEU A  52
 None
 0.97A 3t3zA-5uw2A:
undetectable		 3t3zA-5uw2A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD
(Escherichia
coli) 		3 / 3 ASN A 115
ALA A 113
ARG A 102
 None
 0.68A 3tj7C-5uw2A:
undetectable
3tj7D-5uw2A:
undetectable		 3tj7C-5uw2A:
18.69
3tj7D-5uw2A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5uw2 PROBABLE
PHOSPHOLIPID ABC
TRANSPORTER-BINDING
PROTEIN MLAD
(Escherichia
coli) 		5 / 11 VAL A  82
VAL A  68
ILE A  93
ILE A  86
LEU A 112
 None
 1.07A 5e4dB-5uw2A:
undetectable		 5e4dB-5uw2A:
26.92