SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LWE_A_NVPA999_1 (HIV-1 REVERSE TRANSCRIPTASE)	5uwa	PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC (Escherichia coli)	4 / 7	LEU A 101 VAL A 77 GLY A 74 TYR A 100	None	0.96A	1lweA-5uwaA: undetectable	1lweA-5uwaA: 18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XIU_A_9CRA201_1 (RXR-LIKE PROTEIN)	5uwa	PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC (Escherichia coli)	5 / 12	ALA A 108 GLN A 107 LEU A 109 ALA A 110 VAL A 68	8ND A 301 ( 3.9A) None None None 8ND A 301 ( 4.6A)	0.95A	1xiuA-5uwaA: undetectable	1xiuA-5uwaA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QDJ_A_SAMA301_0 (MAGNESIUM-PROTOPORPH YRIN O-METHYLTRANSFERASE)	5uwa	PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC (Escherichia coli)	5 / 12	GLY A 106 SER A 201 LEU A 109 LEU A 101 VAL A 60	None	0.98A	4qdjA-5uwaA: undetectable	4qdjA-5uwaA: 23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KKL_B_SAMB8009_0 (PUTATIVE UNCHARACTERIZED PROTEIN,HISTONE H3.1 PEPTIDE,ZINC FINGER DOMAIN-CONTAINING PROTEIN)	5uwa	PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC (Escherichia coli)	5 / 12	LEU A 101 TYR A 164 TYR A 72 TYR A 93 LEU A 197	None	1.37A	5kklB-5uwaA: undetectable	5kklB-5uwaA: 12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AY4_A_TPFA506_1 (CYP51, STEROL 14ALPHA-DEMETHYLASE)	5uwa	PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC (Escherichia coli)	5 / 10	MET A 166 PHE A 150 ALA A 35 THR A 38 LEU A 109	8ND A 301 ( 3.9A) 8ND A 301 (-4.0A) 8ND A 301 ( 4.2A) 8ND A 301 ( 4.8A) None	1.40A	6ay4A-5uwaA: 2.0	6ay4A-5uwaA: 18.46

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1LWE_A_NVPA999_1","HIV-1 REVERSE TRANSCRIPTASE","5uwa","PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC","Escherichia coli",4,"LEU A 101;VAL A  77;GLY A  74;TYR A 100","None","0.96A","1lweA-5uwaA:undetectable","1lweA-5uwaA:18.99"],["1XIU_A_9CRA201_1","RXR-LIKE PROTEIN","5uwa","PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC","Escherichia coli",5,"ALA A 108;GLN A 107;LEU A 109;ALA A 110;VAL A  68","8ND A 301 ( 3.9A);None;None;None;8ND A 301 ( 4.6A)","0.95A","1xiuA-5uwaA:undetectable","1xiuA-5uwaA:22.27"],["4QDJ_A_SAMA301_0","MAGNESIUM-PROTOPORPHYRIN O-METHYLTRANSFERASE","5uwa","PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC","Escherichia coli",5,"GLY A 106;SER A 201;LEU A 109;LEU A 101;VAL A  60","None","0.98A","4qdjA-5uwaA:undetectable","4qdjA-5uwaA:23.11"],["5KKL_B_SAMB8009_0","PUTATIVE UNCHARACTERIZED PROTEIN,HISTONE H3.1 PEPTIDE,ZINC FINGER DOMAIN-CONTAINING PROTEIN","5uwa","PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC","Escherichia coli",5,"LEU A 101;TYR A 164;TYR A  72;TYR A  93;LEU A 197","None","1.37A","5kklB-5uwaA:undetectable","5kklB-5uwaA:12.34"],["6AY4_A_TPFA506_1","CYP51, STEROL 14ALPHA-DEMETHYLASE","5uwa","PROBABLE PHOSPHOLIPID-BINDING PROTEIN MLAC","Escherichia coli",5,"MET A 166;PHE A 150;ALA A  35;THR A  38;LEU A 109","8ND A 301 ( 3.9A);8ND A 301 (-4.0A);8ND A 301 ( 4.2A);8ND A 301 ( 4.8A);None","1.40A","6ay4A-5uwaA:2.0","6ay4A-5uwaA:18.46"]]