SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uwb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ONI_H_BEZH515_0 (14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 6	PHE B 173 ALA B 202 TYR B 105 ILE B 167	None None PEF B 301 (-4.0A) None	1.23A	1oniH-5uwbB: undetectable 1oniI-5uwbB: undetectable	1oniH-5uwbB: 21.82 1oniI-5uwbB: 21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_A_ZPCA1318_2 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 7	TYR B 144 VAL B 164 ILE B 167 ASN B 165	PEF B 302 (-4.0A) PEF B 302 ( 4.6A) None PEF B 302 ( 4.1A)	0.97A	4a97E-5uwbB: undetectable	4a97E-5uwbB: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 8	TYR B 144 VAL B 164 ILE B 167 ASN B 165	PEF B 302 (-4.0A) PEF B 302 ( 4.6A) None PEF B 302 ( 4.1A)	0.94A	4a97C-5uwbB: undetectable	4a97C-5uwbB: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 8	TYR B 144 VAL B 164 ILE B 167 ASN B 165	PEF B 302 (-4.0A) PEF B 302 ( 4.6A) None PEF B 302 ( 4.1A)	1.00A	4a97D-5uwbB: undetectable	4a97D-5uwbB: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 8	TYR B 144 VAL B 164 ILE B 167 ASN B 165	PEF B 302 (-4.0A) PEF B 302 ( 4.6A) None PEF B 302 ( 4.1A)	0.95A	4a97G-5uwbB: undetectable	4a97G-5uwbB: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_I_ZPCI1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 7	TYR B 144 VAL B 164 ILE B 167 ASN B 165	PEF B 302 (-4.0A) PEF B 302 ( 4.6A) None PEF B 302 ( 4.1A)	0.95A	4a97H-5uwbB: undetectable	4a97H-5uwbB: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_J_ZPCJ1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5uwb	TOLUENE TOLERANCE PROTEIN (Pseudomonas putida)	4 / 8	TYR B 144 VAL B 164 ILE B 167 ASN B 165	PEF B 302 (-4.0A) PEF B 302 ( 4.6A) None PEF B 302 ( 4.1A)	1.03A	4a97I-5uwbB: undetectable	4a97I-5uwbB: 19.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ONI_H_BEZH515_0","14.5 KDA TRANSLATIONAL INHIBITOR PROTEIN","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"PHE B 173;ALA B 202;TYR B 105;ILE B 167","None;None;PEF B 301 (-4.0A);None","1.23A","1oniH-5uwbB:undetectable;1oniI-5uwbB:undetectable","1oniH-5uwbB:21.82;1oniI-5uwbB:21.82"],["4A97_A_ZPCA1318_2","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"TYR B 144;VAL B 164;ILE B 167;ASN B 165","PEF B 302 (-4.0A);PEF B 302 ( 4.6A);None;PEF B 302 ( 4.1A)","0.97A","4a97E-5uwbB:undetectable","4a97E-5uwbB:19.11"],["4A97_D_ZPCD1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"TYR B 144;VAL B 164;ILE B 167;ASN B 165","PEF B 302 (-4.0A);PEF B 302 ( 4.6A);None;PEF B 302 ( 4.1A)","0.94A","4a97C-5uwbB:undetectable","4a97C-5uwbB:19.11"],["4A97_E_ZPCE1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"TYR B 144;VAL B 164;ILE B 167;ASN B 165","PEF B 302 (-4.0A);PEF B 302 ( 4.6A);None;PEF B 302 ( 4.1A)","1.00A","4a97D-5uwbB:undetectable","4a97D-5uwbB:19.11"],["4A97_H_ZPCH1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"TYR B 144;VAL B 164;ILE B 167;ASN B 165","PEF B 302 (-4.0A);PEF B 302 ( 4.6A);None;PEF B 302 ( 4.1A)","0.95A","4a97G-5uwbB:undetectable","4a97G-5uwbB:19.11"],["4A97_I_ZPCI1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"TYR B 144;VAL B 164;ILE B 167;ASN B 165","PEF B 302 (-4.0A);PEF B 302 ( 4.6A);None;PEF B 302 ( 4.1A)","0.95A","4a97H-5uwbB:undetectable","4a97H-5uwbB:19.11"],["4A97_J_ZPCJ1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5uwb","TOLUENE TOLERANCE PROTEIN","Pseudomonas putida",4,"TYR B 144;VAL B 164;ILE B 167;ASN B 165","PEF B 302 (-4.0A);PEF B 302 ( 4.6A);None;PEF B 302 ( 4.1A)","1.03A","4a97I-5uwbB:undetectable","4a97I-5uwbB:19.11"]]