SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 11 GLY A 272
VAL A 239
GLY A   8
ILE A   6
VAL A 243
 FAD  A 401 (-3.1A)
FAD  A 401 (-4.3A)
FAD  A 401 ( 3.8A)
None
None
 0.89A 1hxwB-5uwyA:
undetectable		 1hxwB-5uwyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 10 THR A 107
ILE A 105
ASP A 250
ILE A 265
THR A 263
 FAD  A 401 (-4.2A)
None
None
None
None
 1.30A 1i18A-5uwyA:
undetectable
1i18B-5uwyA:
undetectable		 1i18A-5uwyA:
15.41
1i18B-5uwyA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		6 / 11 GLY A 289
ALA A  12
ASP A 273
VAL A 274
GLY A   8
ILE A  29
 None
FAD  A 401 (-3.5A)
FAD  A 401 (-2.7A)
None
FAD  A 401 ( 3.8A)
None
 1.43A 1n49B-5uwyA:
undetectable		 1n49B-5uwyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		6 / 11 GLY A 289
ALA A  12
ASP A 273
VAL A 274
GLY A   8
ILE A  29
 None
FAD  A 401 (-3.5A)
FAD  A 401 (-2.7A)
None
FAD  A 401 ( 3.8A)
None
 1.44A 1n49C-5uwyA:
undetectable		 1n49C-5uwyA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 MET A   1
VAL A 296
LEU A 300
PHE A 303
 None
 1.08A 1x8vA-5uwyA:
undetectable		 1x8vA-5uwyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 196
ARG A 171
ARG A 172
 None
 0.86A 2j9dA-5uwyA:
undetectable
2j9dC-5uwyA:
undetectable		 2j9dA-5uwyA:
21.00
2j9dC-5uwyA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 PRO A  35
GLY A  10
ILE A   6
GLY A   8
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 ( 3.8A)
 0.82A 2jkjA-5uwyA:
undetectable		 2jkjA-5uwyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 PRO A  35
GLY A  10
ILE A   6
GLY A   8
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 ( 3.8A)
 0.82A 2jkjB-5uwyA:
undetectable		 2jkjB-5uwyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 PRO A  35
GLY A  10
ILE A   6
GLY A   8
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 ( 3.8A)
 0.83A 2jkjC-5uwyA:
undetectable		 2jkjC-5uwyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 6 PRO A  35
GLY A  10
ILE A   6
GLY A   8
 None
FAD  A 401 (-3.3A)
None
FAD  A 401 ( 3.8A)
 0.85A 2jklB-5uwyA:
undetectable		 2jklB-5uwyA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 VAL A  27
THR A   4
VAL A 296
GLY A 293
 None
 1.02A 2p2fA-5uwyA:
2.1		 2p2fA-5uwyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 4 VAL A  27
THR A   4
VAL A 296
GLY A 293
 None
 1.04A 2p2fB-5uwyA:
undetectable		 2p2fB-5uwyA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 ILE A   7
THR A 107
ASN A  84
VAL A  79
VAL A 243
 None
FAD  A 401 (-4.2A)
None
FAD  A 401 (-4.2A)
None
 1.23A 2vn0A-5uwyA:
undetectable		 2vn0A-5uwyA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		3 / 3 LEU A 159
TYR A 158
GLN A 161
 None
 0.71A 2wekA-5uwyA:
2.9		 2wekA-5uwyA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 11 ALA A 106
GLY A 287
THR A 284
ALA A 285
ASP A 273
 None
PO4  A 402 (-3.6A)
None
FAD  A 401 ( 4.0A)
FAD  A 401 (-2.7A)
 1.15A 3mg0V-5uwyA:
undetectable
3mg0W-5uwyA:
undetectable		 3mg0V-5uwyA:
21.45
3mg0W-5uwyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 5 VAL A 243
LEU A 246
ILE A 248
VAL A 103
 None
 0.87A 4a9kB-5uwyA:
undetectable		 4a9kB-5uwyA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 4 VAL A 127
THR A 123
GLU A 119
GLU A 120
 None
 1.45A 4l78A-5uwyA:
undetectable		 4l78A-5uwyA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		4 / 7 VAL A  91
ILE A  30
ILE A  75
ALA A  28
 None
 0.92A 4lv9B-5uwyA:
undetectable		 4lv9B-5uwyA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 11 THR A  42
GLU A 155
ASP A  44
ASP A 134
TYR A 129
 FAD  A 401 (-3.3A)
None
None
FAD  A 401 (-3.9A)
None
 1.38A 4qb9F-5uwyA:
undetectable		 4qb9F-5uwyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 290
GLY A 287
ALA A  12
THR A  15
ASP A 273
 None
PO4  A 402 (-3.6A)
FAD  A 401 (-3.5A)
None
FAD  A 401 (-2.7A)
 1.33A 5l5zH-5uwyA:
undetectable
5l5zI-5uwyA:
undetectable		 5l5zH-5uwyA:
24.17
5l5zI-5uwyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5uwy THIOREDOXIN
REDUCTASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 290
GLY A 287
ALA A  12
THR A  15
ASP A 273
 None
PO4  A 402 (-3.6A)
FAD  A 401 (-3.5A)
None
FAD  A 401 (-2.7A)
 1.34A 5l5zV-5uwyA:
undetectable
5l5zW-5uwyA:
undetectable		 5l5zV-5uwyA:
24.17
5l5zW-5uwyA:
22.76