SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uwz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		5 / 11 LEU A 156
ALA A 172
VAL A 109
MET A 224
LEU A 211
 None
 1.29A 1hbpA-5uwzA:
undetectable		 1hbpA-5uwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		5 / 12 PHE A  68
ILE A  25
LEU A 182
ALA A  27
ASP A 202
 STE  A 303 (-4.3A)
STE  A 303 (-4.2A)
None
None
None
 1.39A 2iyfB-5uwzA:
undetectable		 2iyfB-5uwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		4 / 6 LEU A 211
LEU A 156
GLU A 168
MET A 224
 None
 0.97A 2kuhA-5uwzA:
undetectable		 2kuhA-5uwzA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		5 / 12 PHE A  88
TYR A  87
VAL A 178
ALA A 119
ILE A  25
 EDO  A 301 ( 4.7A)
None
None
STE  A 303 (-3.1A)
STE  A 303 (-4.2A)
 1.08A 2qm9B-5uwzA:
undetectable		 2qm9B-5uwzA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		4 / 8 VAL A 137
ASP A 131
LEU A  75
TYR A  22
 None
None
None
STE  A 303 (-4.5A)
 1.01A 3af0A-5uwzA:
undetectable		 3af0A-5uwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		4 / 6 ASN A  26
SER A  23
ALA A  27
ASP A  81
 STE  A 303 (-4.0A)
None
None
None
 1.19A 3aruA-5uwzA:
undetectable		 3aruA-5uwzA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		5 / 11 TYR A  87
VAL A 185
ILE A  25
MET A 194
LEU A 192
 None
EDO  A 302 ( 4.8A)
STE  A 303 (-4.2A)
STE  A 303 (-4.0A)
None
 1.46A 4lhmA-5uwzA:
2.2		 4lhmA-5uwzA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		3 / 3 ILE A 114
MET A 224
ARG A 227
 None
 0.89A 4lnwA-5uwzA:
undetectable		 4lnwA-5uwzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		3 / 3 ILE A 114
MET A 224
ARG A 227
 None
 0.89A 4lnxA-5uwzA:
undetectable		 4lnxA-5uwzA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		5 / 12 THR A  42
GLN A  96
GLN A  97
GLU A 101
ILE A 110
 None
EDO  A 301 ( 4.9A)
None
None
None
 1.31A 4s0vA-5uwzA:
2.3		 4s0vA-5uwzA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5uwz ALDEHYDE
DECARBONYLASE
(Gloeobacter
violaceus) 		3 / 3 VAL A 137
GLN A  69
CYH A  71
 None
None
STE  A 303 ( 4.4A)
 0.57A 5icxA-5uwzA:
undetectable
5icxE-5uwzA:
undetectable		 5icxA-5uwzA:
15.87
5icxE-5uwzA:
7.04