SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ux2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 6 TYR A  11
LEU A  68
VAL A  70
VAL A  22
 None
 1.17A 1dz4A-5ux2A:
undetectable		 1dz4A-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 6 TYR A  11
LEU A  68
VAL A  70
VAL A  22
 None
 1.15A 1dz4B-5ux2A:
undetectable		 1dz4B-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 10 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.25A 1gwrA-5ux2A:
2.1		 1gwrA-5ux2A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 7 VAL A  21
ILE A 185
MET A 174
LEU A  80
 None
 0.96A 1iepB-5ux2A:
undetectable		 1iepB-5ux2A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 10 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.27A 1pcgA-5ux2A:
2.3		 1pcgA-5ux2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 10 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.30A 1pcgB-5ux2A:
2.2		 1pcgB-5ux2A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 5 TYR A  11
LEU A  68
VAL A  70
VAL A  22
 None
 1.19A 2m56A-5ux2A:
undetectable		 2m56A-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 5 ALA A  77
ALA A  14
TYR A  15
MET A 187
 None
 1.29A 3d91A-5ux2A:
undetectable		 3d91A-5ux2A:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 5 ALA A 112
GLU A  54
GLU A  26
ALA A  29
 PPI  A 303 ( 3.7A)
FE  A 301 (-2.5A)
FE  A 302 ( 2.1A)
PPI  A 303 ( 3.7A)
 1.30A 3r9tC-5ux2A:
undetectable		 3r9tC-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 6 PHE A  81
PHE A 111
ALA A 115
THR A 192
 None
 0.87A 3t3sB-5ux2A:
undetectable		 3t3sB-5ux2A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 11 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.30A 3uudA-5ux2A:
undetectable		 3uudA-5ux2A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		6 / 12 LEU A 149
GLU A 140
GLY A 105
PHE A  33
LEU A  47
ARG A  49
 None
 1.45A 4hytA-5ux2A:
2.3		 4hytA-5ux2A:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 10 CYH A 110
LEU A 106
HIS A 141
LEU A 142
ALA A 145
 None
None
FE  A 301 (-3.5A)
None
None
 1.09A 4p65A-5ux2A:
undetectable
4p65B-5ux2A:
undetectable
4p65F-5ux2A:
undetectable
4p65H-5ux2A:
undetectable		 4p65A-5ux2A:
undetectable
4p65B-5ux2A:
undetectable
4p65F-5ux2A:
undetectable
4p65H-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 11 CYH A 110
LEU A 106
HIS A 141
LEU A 142
ALA A 145
 None
None
FE  A 301 (-3.5A)
None
None
 1.13A 4p65C-5ux2A:
undetectable
4p65D-5ux2A:
undetectable
4p65J-5ux2A:
undetectable
4p65L-5ux2A:
undetectable		 4p65C-5ux2A:
undetectable
4p65D-5ux2A:
undetectable
4p65J-5ux2A:
undetectable
4p65L-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 11 CYH A 110
LEU A 106
HIS A 141
LEU A 142
ALA A 145
 None
None
FE  A 301 (-3.5A)
None
None
 1.03A 4p65B-5ux2A:
undetectable
4p65D-5ux2A:
undetectable
4p65G-5ux2A:
undetectable
4p65H-5ux2A:
undetectable		 4p65B-5ux2A:
undetectable
4p65D-5ux2A:
undetectable
4p65G-5ux2A:
undetectable
4p65H-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 11 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.34A 4zn7B-5ux2A:
undetectable		 4zn7B-5ux2A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 10 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.31A 5dxeB-5ux2A:
2.1		 5dxeB-5ux2A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 4 CYH A 110
LEU A 106
LEU A 142
ALA A 145
 None
 1.02A 5hpuA-5ux2A:
undetectable
5hpuB-5ux2A:
undetectable		 5hpuA-5ux2A:
undetectable
5hpuB-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 6 CYH A 110
LEU A 106
HIS A 141
LEU A 142
 None
None
FE  A 301 (-3.5A)
None
 1.08A 5hpuC-5ux2A:
undetectable
5hpuD-5ux2A:
undetectable		 5hpuC-5ux2A:
undetectable
5hpuD-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 7 CYH A 110
HIS A 141
LEU A 142
ALA A 145
 None
FE  A 301 (-3.5A)
None
None
 0.81A 5hrqE-5ux2A:
undetectable
5hrqF-5ux2A:
undetectable
5hrqJ-5ux2A:
undetectable		 5hrqE-5ux2A:
undetectable
5hrqF-5ux2A:
undetectable
5hrqJ-5ux2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		5 / 10 LEU A 199
ALA A 203
GLU A 146
LEU A 106
LEU A 218
 None
 1.43A 5hyrA-5ux2A:
undetectable		 5hyrA-5ux2A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ux2 ALDEHYDE
DECARBONYLASE
(Synechococcus
sp.
RS9917) 		4 / 5 LEU A 106
PHE A 200
LEU A 204
PHE A 209
 None
 1.04A 5x19C-5ux2A:
3.4
5x19J-5ux2A:
undetectable		 5x19C-5ux2A:
undetectable
5x19J-5ux2A:
undetectable