SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uxb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 11 LEU A  50
ALA A  36
LEU A  19
ALA A  12
LEU A   9
 None
 1.18A 1ictA-5uxbA:
undetectable
1ictC-5uxbA:
undetectable		 1ictA-5uxbA:
18.73
1ictC-5uxbA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		3 / 3 ALA A  77
VAL A 212
TRP A 215
 None
 0.83A 1kqeA-5uxbA:
undetectable
1kqeE-5uxbA:
undetectable		 1kqeA-5uxbA:
4.02
1kqeE-5uxbA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		3 / 3 ALA A  77
VAL A 212
TRP A 215
 None
 0.84A 1kqeB-5uxbA:
undetectable
1kqeD-5uxbA:
undetectable		 1kqeB-5uxbA:
4.02
1kqeD-5uxbA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		3 / 3 TRP A 215
ALA A  77
VAL A 212
 None
 0.84A 1kqeB-5uxbA:
undetectable
1kqeD-5uxbA:
undetectable		 1kqeB-5uxbA:
4.02
1kqeD-5uxbA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		3 / 3 TRP A 215
ALA A  77
VAL A 212
 None
 0.84A 1kqeA-5uxbA:
undetectable
1kqeE-5uxbA:
undetectable		 1kqeA-5uxbA:
4.02
1kqeE-5uxbA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		4 / 7 TYR A 246
CYH A 261
HIS A 131
TRP A 254
 None
 1.41A 1yvmA-5uxbA:
undetectable		 1yvmA-5uxbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		4 / 6 PHE A 239
ALA A 258
ALA A 224
PRO A 223
 None
 0.96A 4dtzB-5uxbA:
undetectable		 4dtzB-5uxbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		4 / 7 PHE A 239
ALA A 258
ALA A 224
PRO A 223
 None
 0.91A 4du2A-5uxbA:
undetectable		 4du2A-5uxbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 LEU A  67
GLU A  63
LEU A 213
ILE A 209
LEU A 130
 None
 1.21A 4j24D-5uxbA:
undetectable		 4j24D-5uxbA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 11 LEU A 257
HIS A 230
LEU A 243
VAL A 127
LEU A 123
 None
 0.89A 4p65C-5uxbA:
undetectable
4p65D-5uxbA:
undetectable
4p65J-5uxbA:
undetectable
4p65L-5uxbA:
undetectable		 4p65C-5uxbA:
8.55
4p65D-5uxbA:
8.64
4p65J-5uxbA:
8.64
4p65L-5uxbA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 VAL A 127
LEU A 123
LEU A 243
LEU A 257
HIS A 230
 None
 0.85A 4p65B-5uxbA:
undetectable
4p65D-5uxbA:
undetectable
4p65I-5uxbA:
undetectable
4p65J-5uxbA:
undetectable		 4p65B-5uxbA:
8.64
4p65D-5uxbA:
8.64
4p65I-5uxbA:
8.55
4p65J-5uxbA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 LEU A 243
VAL A 127
LEU A 123
LEU A 257
HIS A 230
 None
 0.91A 4p65F-5uxbA:
undetectable
4p65H-5uxbA:
undetectable
4p65K-5uxbA:
undetectable
4p65L-5uxbA:
undetectable		 4p65F-5uxbA:
8.64
4p65H-5uxbA:
8.64
4p65K-5uxbA:
8.55
4p65L-5uxbA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		3 / 3 ALA A  90
TRP A  46
VAL A  47
 None
 0.29A 4w9nC-5uxbA:
undetectable		 4w9nC-5uxbA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 ALA A 128
GLY A 124
LEU A 130
ALA A 247
GLY A 250
 None
 1.41A 5jglB-5uxbA:
undetectable		 5jglB-5uxbA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 VAL A 127
LEU A 130
TRP A 215
ALA A 138
GLY A 195
 None
 1.09A 5kirA-5uxbA:
undetectable		 5kirA-5uxbA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 7 THR A  23
PHE A  37
ASP A  45
LEU A  93
SER A  97
 None
 0.78A 5uxcA-5uxbA:
41.6		 5uxcA-5uxbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 7 GLU A 196
TYR A 198
ALA A 268
GLY A 271
TYR A 275
 None
 0.56A 5uxdA-5uxbA:
41.8		 5uxdA-5uxbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		6 / 12 LEU A 100
VAL A 108
TYR A 198
PHE A 265
ALA A 268
GLY A 271
 None
 0.85A 5uxdB-5uxbA:
32.1		 5uxdB-5uxbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 VAL A 108
GLU A 196
TYR A 198
ALA A 268
GLY A 271
 None
 0.67A 5uxdB-5uxbA:
32.1		 5uxdB-5uxbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.97A 5wz1A-5uxbA:
undetectable		 5wz1A-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.97A 5wz1C-5uxbA:
undetectable		 5wz1C-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.91A 5wz1D-5uxbA:
undetectable		 5wz1D-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.97A 5wz1E-5uxbA:
undetectable		 5wz1E-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.93A 5wz1F-5uxbA:
undetectable		 5wz1F-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.92A 5wz1G-5uxbA:
undetectable		 5wz1G-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		5 / 12 GLY A 256
GLY A 184
TRP A 254
GLU A 263
ASP A 158
 None
 0.93A 5wz1H-5uxbA:
undetectable		 5wz1H-5uxbA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5uxb MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH
(Brachybacterium
faecium) 		4 / 7 ARG A  49
ALA A  36
ILE A  89
ALA A  90
 None
 0.99A 6ma7A-5uxbA:
undetectable		 6ma7A-5uxbA:
14.50