SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 ASP A  92
LEU A  85
LEU A  89
 None
 0.67A 1ikeA-5uxgA:
undetectable		 1ikeA-5uxgA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		4 / 7 LEU A 114
VAL A 117
GLY A 118
ILE A 191
 None
 0.77A 1p2yA-5uxgA:
undetectable		 1p2yA-5uxgA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 GLU A  57
HIS A  60
GLU A 111
ILE A 141
GLU A 145
 None
 0.60A 1rnrA-5uxgA:
15.6		 1rnrA-5uxgA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_B_DAHB208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A  57
HIS A  60
GLU A 111
ILE A 141
GLU A 145
 None
 0.46A 1rnrB-5uxgA:
12.1		 1rnrB-5uxgA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		5 / 10 GLU A 157
ARG A  99
GLY A 152
ARG A 205
ILE A 209
 None
 1.50A 3adsA-5uxgA:
undetectable		 3adsA-5uxgA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  89
PHE A  86
LEU A  35
ILE A 109
SER A  39
 None
 1.33A 3aqiB-5uxgA:
undetectable		 3aqiB-5uxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		5 / 9 LEU A  85
ILE A 184
GLY A 118
ALA A 173
ILE A 176
 None
 1.01A 3el0B-5uxgA:
undetectable		 3el0B-5uxgA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		4 / 8 ARG A 105
GLN A  94
PHE A  93
ASN A 101
 None
 1.30A 3n66B-5uxgA:
undetectable		 3n66B-5uxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		5 / 11 ILE A  16
ASP A   2
PHE A 134
ILE A 141
LEU A 122
 None
 1.24A 3qg2B-5uxgA:
undetectable		 3qg2B-5uxgA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5uxg ALDEHYDE
DEFORMYLATING
OXYGENASE
(Sulfurisphaera
tokodaii) 		3 / 3 LEU A 114
ILE A 109
ARG A 105
 None
 0.70A 4mk4B-5uxgA:
undetectable		 4mk4B-5uxgA:
undetectable