SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uxn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 132
GLY A 134
ALA A  70
ASP A 135
ILE A 136
 None
 1.22A 1nt2A-5uxnA:
undetectable		 1nt2A-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 237
GLU A 241
TRP A 263
ILE A 136
 None
None
PEP  A 504 ( 4.8A)
None
 1.05A 1qvtA-5uxnA:
0.7		 1qvtA-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 336
LEU A 315
LEU A 317
SER A 296
LEU A 299
 None
 0.94A 2xn5A-5uxnA:
undetectable		 2xn5A-5uxnA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 10 ALA A 336
LEU A 315
LEU A 317
SER A 296
LEU A 299
 None
 1.10A 2xn7A-5uxnA:
undetectable
2xn7B-5uxnA:
undetectable		 2xn7A-5uxnA:
11.14
2xn7B-5uxnA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 8 ILE A 391
LEU A  64
THR A 442
VAL A 103
GLY A 390
 None
 1.20A 3dcjB-5uxnA:
undetectable		 3dcjB-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  73
GLY A 134
PHE A 113
SER A  72
HIS A 233
 None
 1.31A 3dlcA-5uxnA:
undetectable		 3dlcA-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 238
VAL A 282
ILE A 264
LEU A 306
THR A 245
 None
 1.14A 3fl9E-5uxnA:
undetectable		 3fl9E-5uxnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 238
VAL A 282
ILE A 264
LEU A 306
THR A 245
 None
 1.07A 3fl9G-5uxnA:
undetectable		 3fl9G-5uxnA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  78
ARG A  82
LYS A  86
 None
 0.54A 3kp3B-5uxnA:
undetectable		 3kp3B-5uxnA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A  78
ARG A  82
LYS A  86
 None
 0.76A 3kp5B-5uxnA:
undetectable		 3kp5B-5uxnA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 8 PHE A  53
VAL A  56
GLY A 389
ILE A 391
 None
 0.80A 3n9jB-5uxnA:
undetectable		 3n9jB-5uxnA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 349
ARG A 320
ASP A 424
 None
PEP  A 504 (-3.9A)
CO  A 503 (-3.4A)
 0.85A 4fp9D-5uxnA:
undetectable		 4fp9D-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 258
TYR A 240
GLN A 112
ALA A 114
GLY A 265
 None
None
PEP  A 504 ( 4.8A)
None
PEP  A 504 (-3.3A)
 0.97A 4j7xA-5uxnA:
undetectable		 4j7xA-5uxnA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 258
TYR A 240
GLN A 112
ALA A 114
GLY A 265
 None
None
PEP  A 504 ( 4.8A)
None
PEP  A 504 (-3.3A)
 0.98A 4j7xB-5uxnA:
undetectable		 4j7xB-5uxnA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  66
GLY A 107
LEU A 427
ALA A 429
LYS A  80
 None
 1.11A 4uckB-5uxnA:
undetectable		 4uckB-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A 268
LEU A 302
GLY A 291
PRO A 292
SER A 293
 None
 1.05A 4ypmA-5uxnA:
undetectable		 4ypmA-5uxnA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 387
ARG A 447
GLY A 100
LEU A 443
 None
 1.29A 5bphD-5uxnA:
undetectable		 5bphD-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 6 ALA A 232
THR A 231
VAL A 106
VAL A  41
HIS A 233
 None
 1.36A 5eckA-5uxnA:
undetectable		 5eckA-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 7 ALA A 232
THR A 231
VAL A 106
VAL A  41
HIS A 233
 None
 1.19A 5ecmD-5uxnA:
undetectable		 5ecmD-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 7 ALA A 232
THR A 231
VAL A 106
VAL A  41
HIS A 233
 None
 1.26A 5ecoD-5uxnA:
undetectable		 5ecoD-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHQ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 106
ASN A 166
ALA A  78
ARG A  82
ASP A  83
 None
 1.19A 5fhqA-5uxnA:
undetectable		 5fhqA-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		3 / 3 CYH A 403
MET A 351
ASN A 354
 None
 1.37A 5qh8A-5uxnA:
undetectable		 5qh8A-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 356
THR A 355
ARG A 320
SER A 118
 None
None
PEP  A 504 (-3.9A)
PO4  A 502 (-2.4A)
 1.03A 6c06C-5uxnA:
undetectable		 6c06C-5uxnA:
undetectable