SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uxx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5uxx RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		4 / 8 LEU A 156
GLN A 157
PHE A 106
LEU A 110
 None
 0.88A 2eikP-5uxxA:
undetectable
2eikW-5uxxA:
undetectable		 2eikP-5uxxA:
undetectable
2eikW-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5uxx RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		4 / 8 LEU A 156
GLN A 157
PHE A 106
LEU A 110
 None
 0.90A 2eilC-5uxxA:
undetectable
2eilJ-5uxxA:
undetectable		 2eilC-5uxxA:
undetectable
2eilJ-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5uxx RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		4 / 7 LEU A 156
GLN A 157
PHE A 106
LEU A 110
 None
 0.91A 3ag2P-5uxxA:
undetectable
3ag2W-5uxxA:
undetectable		 3ag2P-5uxxA:
undetectable
3ag2W-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5uxx ANTI-SIGMA FACTOR
NEPR
RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		4 / 8 GLU A 119
LEU A  26
TYR B  34
PHE A  62
 None
 0.94A 3i45A-5uxxA:
undetectable		 3i45A-5uxxA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5uxx RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		3 / 3 TYR A  70
PHE A  22
ARG A  66
 None
 1.19A 4g19D-5uxxA:
undetectable		 4g19D-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5uxx RNA POLYMERASE SIGMA
FACTOR
ANTI-SIGMA FACTOR
NEPR
(Bartonella
quintana;
Bartonella
quintana) 		5 / 12 PHE A 106
GLU A  89
LEU A  26
ILE A 122
LEU B  30
 None
 1.47A 4k38B-5uxxA:
undetectable		 4k38B-5uxxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5uxx RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		5 / 9 LEU A 110
ALA A 109
PHE A 106
ASP A 105
ILE A 121
 None
 0.94A 5om2A-5uxxA:
undetectable
5om2B-5uxxA:
undetectable		 5om2A-5uxxA:
22.89
5om2B-5uxxA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5uxx RNA POLYMERASE SIGMA
FACTOR
(Bartonella
quintana) 		5 / 12 LEU A  41
VAL A  37
LEU A  19
ARG A  66
PHE A  62
 None
 1.41A 6a7pB-5uxxA:
2.5		 6a7pB-5uxxA:
undetectable