SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
ANTIBODY PGT144 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PHE H  69
TRP H  47
TRP L  96
GLU H  56
 None
 1.43A 2aowA-5uy3H:
undetectable		 2aowA-5uy3H:
19.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
ANTIBODY PGT144 FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		5 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
TYR H  91
 None
 0.75A 2oldA-5uy3L:
16.0
2oldB-5uy3L:
20.2		 2oldA-5uy3L:
40.44
2oldB-5uy3L:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN
(Homo
sapiens) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR L  87
 None
 0.54A 2ombC-5uy3L:
17.6
2ombD-5uy3L:
20.2		 2ombC-5uy3L:
40.44
2ombD-5uy3L:
40.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
ANTIBODY PGT144 FAB
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR L  36
HIS L  38
PRO L  44
TYR H  91
 None
 0.96A 2ombC-5uy3L:
17.6
2ombD-5uy3L:
20.2		 2ombC-5uy3L:
40.44
2ombD-5uy3L:
40.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 168
VAL H 187
SER H 185
ASN H 202
ASN H 160
 None
 1.45A 2y03A-5uy3H:
undetectable		 2y03A-5uy3H:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_D_ACTD229_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 4 ASP H  33
GLY H  95
LYS H  97
GLU H 103
 None
 1.46A 3hznD-5uy3H:
undetectable		 3hznD-5uy3H:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 ASP H  33
ARG H  99
LYS H  97
 None
 1.13A 3wipG-5uy3H:
undetectable		 3wipG-5uy3H:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 GLY L  41
PRO L  40
ALA L  84
 None
 0.56A 4qn9B-5uy3L:
undetectable		 4qn9B-5uy3L:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA H 113
THR H 112
VAL H  18
GLU H  10
 None
 0.96A 5ecnA-5uy3H:
undetectable		 5ecnA-5uy3H:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 5uy3 ANTIBODY PGT144 FAB
LIGHT CHAIN
(Homo
sapiens) 		3 / 3 ARG L  45
PRO L  59
TYR L  86
 None
 1.07A 5tzoB-5uy3L:
undetectable		 5tzoB-5uy3L:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 GLY H  94
LEU H 105
HIS H  35
 None
 0.61A 5u63A-5uy3H:
undetectable		 5u63A-5uy3H:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 5uy3 ANTIBODY PGT144 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 GLY H  94
LEU H 105
HIS H  35
 None
 0.57A 5u63B-5uy3H:
undetectable		 5u63B-5uy3H:
21.66