SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uy7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
LYS A 497
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
SO4  A 701 (-3.4A)
 0.71A 1ghmA-5uy7A:
16.3		 1ghmA-5uy7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
SER A 498
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
SO4  A 701 (-2.6A)
SO4  A 701 (-3.4A)
 0.83A 1ghmA-5uy7A:
16.3		 1ghmA-5uy7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
LYS A 497
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
SO4  A 701 (-3.4A)
 0.70A 1i2wA-5uy7A:
16.5		 1i2wA-5uy7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
THR A 483
LYS A 497
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
None
 0.71A 1i2wA-5uy7A:
16.5		 1i2wA-5uy7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		5 / 11 SER A 360
SER A 361
ASN A 362
THR A 330
GLY A 347
 SO4  A 701 ( 4.3A)
None
None
None
None
 1.37A 1jr1A-5uy7A:
undetectable		 1jr1A-5uy7A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		3 / 3 ASP A 486
PHE A 517
VAL A 478
 None
 0.72A 1kijB-5uy7A:
undetectable		 1kijB-5uy7A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		5 / 12 THR A 559
GLY A 519
ALA A 521
ILE A 528
PHE A 427
 None
 1.46A 1vq1A-5uy7A:
undetectable		 1vq1A-5uy7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		5 / 12 THR A 559
GLY A 519
ALA A 521
ILE A 528
THR A 434
 None
 1.19A 1vq1A-5uy7A:
undetectable		 1vq1A-5uy7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
LYS A 497
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
SO4  A 701 (-3.4A)
 0.79A 1ymxA-5uy7A:
17.0		 1ymxA-5uy7A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
LYS A 497
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
SO4  A 701 (-3.4A)
 0.77A 1ymxB-5uy7A:
17.0		 1ymxB-5uy7A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		4 / 5 LEU A 337
ASP A 338
ALA A 414
ILE A 411
 None
SO4  A 704 ( 4.6A)
None
None
 1.02A 2aofB-5uy7A:
undetectable		 2aofB-5uy7A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		4 / 7 SER A 533
SER A 516
VAL A 518
LEU A 386
 None
 0.79A 2hdnE-5uy7A:
undetectable
2hdnF-5uy7A:
undetectable
2hdnH-5uy7A:
undetectable		 2hdnE-5uy7A:
5.83
2hdnF-5uy7A:
21.23
2hdnH-5uy7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		4 / 7 SER A 516
VAL A 518
LEU A 386
SER A 533
 None
 0.83A 2hdnF-5uy7A:
undetectable
2hdnG-5uy7A:
undetectable
2hdnH-5uy7A:
undetectable		 2hdnF-5uy7A:
21.23
2hdnG-5uy7A:
5.83
2hdnH-5uy7A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		5 / 12 LEU A 429
GLY A 385
GLN A 388
MET A 380
MET A 442
 None
 1.34A 2yhdA-5uy7A:
undetectable		 2yhdA-5uy7A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 9 ALA A 521
VAL A 529
VAL A 494
GLY A 495
GLY A 496
ALA A 556
 None
 1.13A 2z0yA-5uy7A:
undetectable		 2z0yA-5uy7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 9 ALA A 521
VAL A 529
VAL A 494
GLY A 495
GLY A 496
ALA A 556
 None
 1.14A 2z0yB-5uy7A:
undetectable		 2z0yB-5uy7A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		4 / 7 ARG A 514
ALA A 258
PRO A 537
ALA A 256
 None
 1.00A 2zgwA-5uy7A:
undetectable		 2zgwA-5uy7A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		6 / 12 SER A 306
LYS A 309
SER A 360
ASN A 362
LYS A 497
GLY A 499
 SO4  A 701 (-2.5A)
SO4  A 701 ( 4.8A)
SO4  A 701 ( 4.3A)
None
None
SO4  A 701 (-3.4A)
 0.81A 3sh8B-5uy7A:
16.8		 3sh8B-5uy7A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5uy7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE
(Burkholderia
ambifaria) 		5 / 11 PRO A 304
LEU A 429
TYR A 381
GLY A 385
TYR A 433
 None
 1.26A 5hbmA-5uy7A:
undetectable		 5hbmA-5uy7A:
21.94