SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uyg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 12 HIS A 141
HIS A  76
ASP A  77
GLU A 256
ASP A 282
 ZN  A 401 (-3.3A)
ZN  A 401 (-3.3A)
None
None
ZN  A 401 (-2.1A)
 1.08A 1a4lC-5uygA:
undetectable		 1a4lC-5uygA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 12 LEU A  93
ALA A 118
ALA A 159
LEU A 160
ILE A  58
 None
 1.03A 1fk6A-5uygA:
undetectable		 1fk6A-5uygA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ASN A 139
ASN A  97
HIS A  76
VAL A 281
 None
None
ZN  A 401 (-3.3A)
None
 1.39A 1wu8A-5uygA:
undetectable
1wu8C-5uygA:
undetectable		 1wu8A-5uygA:
21.10
1wu8C-5uygA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 6 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.96A 2dcfA-5uygA:
undetectable		 2dcfA-5uygA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.92A 2zm7A-5uygA:
undetectable		 2zm7A-5uygA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 8 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.91A 2zm8A-5uygA:
undetectable		 2zm8A-5uygA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 8 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.91A 2zm9A-5uygA:
undetectable		 2zm9A-5uygA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 8 ALA A 149
TYR A 178
TYR A 294
ILE A 153
 None
 0.94A 2zmaA-5uygA:
undetectable		 2zmaA-5uygA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ILE A 151
LYS A 158
ILE A 156
TYR A 294
 None
 1.08A 3eteD-5uygA:
undetectable
3eteF-5uygA:
undetectable		 3eteD-5uygA:
20.78
3eteF-5uygA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 12 LEU A 185
ILE A 298
PHE A 254
ASP A 303
SER A 194
 None
 1.18A 3ko0K-5uygA:
undetectable
3ko0L-5uygA:
undetectable
3ko0S-5uygA:
undetectable
3ko0T-5uygA:
undetectable		 3ko0K-5uygA:
13.62
3ko0L-5uygA:
13.62
3ko0S-5uygA:
13.62
3ko0T-5uygA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 9 LEU A  95
VAL A  65
ILE A  58
ALA A  59
ALA A 159
 None
 0.93A 3mdvA-5uygA:
undetectable		 3mdvA-5uygA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 10 ILE A  50
PHE A  48
ILE A  51
LEU A 101
HIS A  76
 None
None
None
None
ZN  A 401 (-3.3A)
 1.14A 3o1cA-5uygA:
undetectable		 3o1cA-5uygA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 10 ILE A  50
PHE A  48
ILE A  51
LEU A 101
HIS A  76
 None
None
None
None
ZN  A 401 (-3.3A)
 1.16A 3o1xA-5uygA:
undetectable		 3o1xA-5uygA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ILE A  75
LEU A 101
THR A  49
ILE A  50
 None
 0.91A 3p50A-5uygA:
undetectable		 3p50A-5uygA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ILE A  75
LEU A 101
THR A  49
ILE A  50
 None
 0.91A 3p50B-5uygA:
undetectable		 3p50B-5uygA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ILE A  75
LEU A 101
THR A  49
ILE A  50
 None
 0.91A 3p50C-5uygA:
undetectable		 3p50C-5uygA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ILE A  75
LEU A 101
THR A  49
ILE A  50
 None
 0.91A 3p50D-5uygA:
undetectable		 3p50D-5uygA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ILE A  75
LEU A 101
THR A  49
ILE A  50
 None
 0.93A 3p50E-5uygA:
undetectable		 3p50E-5uygA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 10 ILE A  50
PHE A  48
ILE A  51
LEU A 101
HIS A  76
 None
None
None
None
ZN  A 401 (-3.3A)
 1.15A 3qgzA-5uygA:
undetectable		 3qgzA-5uygA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 7 ASN A 139
ASP A 282
ILE A 227
HIS A  76
 None
ZN  A 401 (-2.1A)
None
ZN  A 401 (-3.3A)
 0.98A 3t01A-5uygA:
undetectable		 3t01A-5uygA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 8 VAL A 281
TRP A 143
HIS A 141
PHE A  48
 None
None
ZN  A 401 (-3.3A)
None
 1.26A 3v35A-5uygA:
undetectable		 3v35A-5uygA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 8 SER A 111
ILE A 112
PHE A 105
GLU A 110
 None
 1.18A 4cx7A-5uygA:
undetectable
4cx7B-5uygA:
undetectable		 4cx7A-5uygA:
22.49
4cx7B-5uygA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		4 / 8 VAL A 241
TYR A 223
GLU A 131
GLY A 233
 None
 0.81A 5e26C-5uygA:
undetectable
5e26D-5uygA:
undetectable		 5e26C-5uygA:
20.61
5e26D-5uygA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 5 ALA A 179
TYR A 178
PRO A 146
GLY A 208
LEU A 297
 None
 0.96A 5eslA-5uygA:
undetectable		 5eslA-5uygA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5uyg PERIPLASMIC CHELATED
IRON-BINDING PROTEIN
YFEA
(Yersinia
pestis) 		5 / 12 GLY A  60
ALA A  59
VAL A  44
LEU A  93
VAL A  65
 None
 1.08A 6dh0B-5uygA:
undetectable		 6dh0B-5uygA:
14.33