SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uyt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 GLY A 199
SER A 201
GLY A  46
SER A  48
HIS A  49
 None
 1.12A 1nbiC-5uytA:
undetectable		 1nbiC-5uytA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 GLY A 199
SER A 201
GLY A  46
SER A  48
HIS A  49
 None
 1.13A 1nbiD-5uytA:
undetectable		 1nbiD-5uytA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 10 GLY A 406
VAL A 388
GLY A 390
THR A 426
VAL A 404
 None
 1.32A 1pwyE-5uytA:
undetectable		 1pwyE-5uytA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 11 ALA A 189
ILE A 141
VAL A 175
LEU A  85
PRO A  25
 None
 0.77A 1rv7A-5uytA:
undetectable
1rv7B-5uytA:
undetectable		 1rv7A-5uytA:
12.92
1rv7B-5uytA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 10 GLY A 406
VAL A 388
GLY A 390
THR A 426
VAL A 404
 None
 1.30A 1v3qE-5uytA:
undetectable		 1v3qE-5uytA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 5 PRO A 289
GLY A 252
ASN A 251
GLY A 250
 None
 1.05A 1zlqA-5uytA:
undetectable		 1zlqA-5uytA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		3 / 3 ARG A 221
ASP A  53
ASP A  73
 None
 0.86A 2ejtA-5uytA:
undetectable		 2ejtA-5uytA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 7 ASN A  75
ALA A  80
ALA A  81
GLN A  72
 None
 0.72A 3a2qA-5uytA:
undetectable		 3a2qA-5uytA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 5 LEU A 124
GLN A 155
THR A 154
LEU A 130
 None
 1.18A 3ce6D-5uytA:
undetectable		 3ce6D-5uytA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 ALA A  30
LEU A  85
ALA A  81
VAL A 175
LEU A 202
 None
 1.04A 3dzyA-5uytA:
undetectable		 3dzyA-5uytA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		3 / 3 SER A  61
ASP A  73
ASN A  75
 None
 0.94A 3lsfB-5uytA:
undetectable
3lsfE-5uytA:
undetectable		 3lsfB-5uytA:
18.93
3lsfE-5uytA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		3 / 3 ASP A  73
ASN A  75
SER A  61
 None
 0.93A 3lsfB-5uytA:
undetectable
3lsfE-5uytA:
undetectable		 3lsfB-5uytA:
18.93
3lsfE-5uytA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 6 LEU A 105
ALA A 122
LEU A 124
SER A 150
 None
 0.81A 4d7bB-5uytA:
undetectable		 4d7bB-5uytA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_A_SAMA900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 TYR A 245
GLY A 283
GLY A 264
ALA A 278
HIS A 286
 None
 1.06A 4krhA-5uytA:
undetectable		 4krhA-5uytA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 TYR A 245
GLY A 283
GLY A 264
ALA A 278
HIS A 286
 None
 1.07A 4krhB-5uytA:
undetectable		 4krhB-5uytA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 ALA A  77
GLY A  76
GLY A  55
ASN A  32
PHE A  33
 None
 1.17A 4obwA-5uytA:
undetectable		 4obwA-5uytA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 ALA A  77
GLY A  76
GLY A  55
ASN A  32
PHE A  33
 None
 1.06A 4obwB-5uytA:
undetectable		 4obwB-5uytA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 12 ALA A  77
GLY A  76
GLY A  55
ASN A  32
PHE A  33
 None
 1.13A 4obwD-5uytA:
undetectable		 4obwD-5uytA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 11 THR A  78
THR A  38
THR A 210
GLY A  55
ALA A  59
 None
 1.33A 4qvqV-5uytA:
undetectable
4qvqb-5uytA:
undetectable		 4qvqV-5uytA:
19.44
4qvqb-5uytA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		5 / 11 THR A  78
THR A  38
THR A 210
GLY A  55
ALA A  59
 None
 1.34A 4qvqH-5uytA:
undetectable
4qvqN-5uytA:
undetectable		 4qvqH-5uytA:
19.44
4qvqN-5uytA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 7 ASP A 313
THR A 332
PRO A 234
THR A 232
 None
 1.20A 5b6iA-5uytA:
undetectable		 5b6iA-5uytA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 6 ARG A 422
ALA A 303
PRO A 237
PHE A 385
 None
 1.17A 5odqA-5uytA:
undetectable		 5odqA-5uytA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 7 ASP A 396
ASN A 395
LYS A 399
GLU A 418
 None
 1.00A 6ci6A-5uytA:
undetectable		 6ci6A-5uytA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 5uyt ICE-BINDING PROTEIN
(Flavobacteriacea
e
bacterium
3519-10) 		4 / 5 LEU A 157
THR A 127
THR A 110
GLY A 108
 None
 1.26A 6gtqA-5uytA:
undetectable		 6gtqA-5uytA:
15.06