SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae) 		4 / 5 THR E 440
THR E 441
GLU E 404
THR E 405
 None
 1.30A 1d4fB-5uz5E:
undetectable		 1d4fB-5uz5E:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
PROTEIN NAM8
(Saccharomyces
cerevisiae) 		4 / 8 LEU F 323
ASN E 426
ASP E 365
THR E 370
 None
 1.05A 1ig3A-5uz5F:
undetectable
1ig3B-5uz5F:
undetectable		 1ig3A-5uz5F:
19.27
1ig3B-5uz5F:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 5uz5 PROTEIN LUC7
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 12 MET H  71
SER D  21
ILE H  44
TYR H  48
HIS H  76
 None
 1.33A 1ot7A-5uz5H:
undetectable		 1ot7A-5uz5H:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 7 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.08A 1rxcD-5uz5G:
undetectable		 1rxcD-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 GLU E 589
ARG D 104
HIS D 296
GLU D 135
 None
 1.24A 1s3zA-5uz5E:
undetectable
1s3zB-5uz5E:
undetectable		 1s3zA-5uz5E:
13.04
1s3zB-5uz5E:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae) 		3 / 3 THR E 566
GLU E 579
HIS E 563
 None
 0.80A 1xwfA-5uz5E:
undetectable		 1xwfA-5uz5E:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae) 		3 / 3 THR E 566
GLU E 579
HIS E 563
 None
 0.81A 1xwfB-5uz5E:
undetectable		 1xwfB-5uz5E:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae) 		3 / 3 THR E 566
GLU E 579
HIS E 563
 None
 0.81A 1xwfC-5uz5E:
undetectable		 1xwfC-5uz5E:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae) 		3 / 3 THR E 566
GLU E 579
HIS E 563
 None
 0.79A 1xwfD-5uz5E:
undetectable		 1xwfD-5uz5E:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 4 LEU D 108
SER D 111
TYR D 112
LEU D  98
 None
 1.08A 1xz1A-5uz5D:
3.0		 1xz1A-5uz5D:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 4 LEU D 108
SER D 111
TYR D 112
LEU D  98
 None
 1.09A 1xz3A-5uz5D:
3.0		 1xz3A-5uz5D:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
PROTEIN NAM8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 7 VAL E 435
SER E 431
LEU E 472
PHE F 522
 None
 1.12A 2f78B-5uz5E:
undetectable		 2f78B-5uz5E:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae) 		4 / 6 TYR E 330
TRP E 362
TYR E 358
ILE E 361
 None
 1.44A 2pgzD-5uz5E:
undetectable
2pgzE-5uz5E:
undetectable		 2pgzD-5uz5E:
15.92
2pgzE-5uz5E:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 6 ILE D 190
PRO E 603
LEU D 212
ILE D 236
 None
 0.89A 2q83B-5uz5D:
undetectable		 2q83B-5uz5D:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PROTEIN NAM8
56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 5 LEU F 438
PRO F 439
LEU D 342
ILE G 256
 None
 0.86A 2qd4A-5uz5F:
undetectable		 2qd4A-5uz5F:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PROTEIN NAM8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 PHE D 488
SER F 517
LEU F 513
 None
 0.81A 2w1bA-5uz5D:
undetectable		 2w1bA-5uz5D:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 12 THR D 396
LEU D 444
LEU D 415
GLY D 414
HIS E 519
 None
 1.35A 2zj0B-5uz5D:
undetectable		 2zj0B-5uz5D:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		3 / 3 PRO G 254
GLU D 372
TYR D 375
 None
 0.81A 2zmbA-5uz5G:
undetectable		 2zmbA-5uz5G:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN 70
KDA HOMOLOG
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG B 124
ASP B 103
ASN A   2
 None
 0.76A 2zzmA-5uz5B:
undetectable		 2zzmA-5uz5B:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 5 VAL G 195
VAL G 194
PHE G 161
ARG D 104
 None
 1.14A 3bjwB-5uz5G:
undetectable		 3bjwB-5uz5G:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 12 THR D 396
LEU D 444
LEU D 415
GLY D 414
HIS E 519
 None
 1.33A 3ce6B-5uz5D:
undetectable		 3ce6B-5uz5D:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 ILE D 174
GLY D 144
LEU D 297
ARG D 301
 None
 0.90A 3elzA-5uz5D:
undetectable		 3elzA-5uz5D:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 GLN D 188
LEU D 172
LEU D 202
LEU B  97
 None
 0.87A 3g8iA-5uz5D:
undetectable		 3g8iA-5uz5D:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 12 GLY D 144
LEU D 297
ILE D 174
LEU B 108
TYR B 109
 None
 1.14A 3g9eA-5uz5D:
undetectable		 3g9eA-5uz5D:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		3 / 3 ILE D 486
SER D 491
SER D 449
 None
 0.61A 3iltH-5uz5D:
undetectable		 3iltH-5uz5D:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.14A 3kvvA-5uz5G:
undetectable		 3kvvA-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.13A 3kvvB-5uz5G:
undetectable		 3kvvB-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.13A 3kvvC-5uz5G:
undetectable		 3kvvC-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.12A 3kvvD-5uz5G:
undetectable		 3kvvD-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.11A 3kvvE-5uz5G:
undetectable		 3kvvE-5uz5G:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ILE D  75
VAL B 118
ARG B 124
 None
 0.72A 3p73A-5uz5D:
undetectable		 3p73A-5uz5D:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 10 PHE G 120
VAL G 222
PHE G 224
PHE G 201
ASN G 193
 None
 1.34A 3r6wA-5uz5G:
undetectable
3r6wB-5uz5G:
undetectable		 3r6wA-5uz5G:
18.22
3r6wB-5uz5G:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLN G 200
TYR G 162
PHE G 235
PRO G  73
 None
 1.18A 3tgvB-5uz5G:
undetectable		 3tgvB-5uz5G:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLN G 200
TYR G 162
PHE G 235
PRO G  73
 None
 1.18A 3tgvD-5uz5G:
undetectable		 3tgvD-5uz5G:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 11 TYR D 448
LEU E 494
LEU E 487
ILE E 508
PHE E 515
 None
 1.42A 4a7aA-5uz5D:
undetectable		 4a7aA-5uz5D:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLY G 159
GLN G 136
MET G  74
VAL G 203
 None
 1.16A 4e1vF-5uz5G:
undetectable		 4e1vF-5uz5G:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PROTEIN NAM8
56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 LEU F 438
PRO F 439
LEU D 342
ILE G 256
 None
 0.96A 4f4dB-5uz5F:
undetectable		 4f4dB-5uz5F:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5uz5 PROTEIN NAM8
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		3 / 3 TYR D 241
GLN F 293
TRP D 186
 None
 0.88A 4kn2C-5uz5D:
undetectable		 4kn2C-5uz5D:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 12 THR D 396
LEU D 444
LEU D 415
GLY D 414
HIS E 519
 None
 1.31A 4pfjB-5uz5D:
undetectable		 4pfjB-5uz5D:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 5uz5 PROTEIN LUC7
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		5 / 12 MET H  71
SER D  21
ILE H  44
TYR H  48
HIS H  76
 None
 1.27A 4qe6A-5uz5H:
undetectable		 4qe6A-5uz5H:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 GLU D  31
LEU D  80
TYR D  73
ARG B 156
 None
 1.21A 4twdF-5uz5D:
2.5
4twdJ-5uz5D:
undetectable		 4twdF-5uz5D:
19.89
4twdJ-5uz5D:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
PROTEIN NAM8
(Saccharomyces
cerevisiae) 		3 / 3 MET G 281
GLN F 407
TYR G 291
 None
 1.10A 4udcA-5uz5G:
undetectable		 4udcA-5uz5G:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5uz5 PROTEIN LUC7
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 VAL D  20
TRP D  30
HIS H  40
LEU D  55
 None
 1.23A 4xo7B-5uz5D:
undetectable		 4xo7B-5uz5D:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 6 SER D 527
PRO D 530
PHE D 529
GLU D 532
 None
 0.95A 5b8iA-5uz5D:
undetectable		 5b8iA-5uz5D:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 6 TYR D 316
ILE D 321
VAL D 333
ALA D 330
 None
 0.83A 5cu6A-5uz5D:
undetectable		 5cu6A-5uz5D:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN C
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		3 / 3 PRO B 113
LEU D  64
SER D 266
 None
 0.69A 5fsaB-5uz5B:
undetectable		 5fsaB-5uz5B:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
PRE-MRNA-PROCESSING
FACTOR 39
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 TYR D 448
ILE E 438
THR E 473
PHE E 455
LEU E 445
 None
 1.36A 5l8oB-5uz5D:
undetectable		 5l8oB-5uz5D:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 THR E 518
HIS E 519
GLN D 411
THR D 452
 None
 1.27A 5u6mA-5uz5E:
undetectable		 5u6mA-5uz5E:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 THR E 518
HIS E 519
GLN D 411
THR D 452
 None
 1.25A 5u6mB-5uz5E:
undetectable		 5u6mB-5uz5E:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 7 ASN D  19
ASP G 262
ASP G 258
GLY G 259
 None
 1.13A 5x7pA-5uz5D:
undetectable		 5x7pA-5uz5D:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_1
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		3 / 3 GLU D 256
TRP D 279
HIS D 140
 None
 1.09A 5xipA-5uz5D:
undetectable		 5xipA-5uz5D:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5uz5 PRE-MRNA-PROCESSING
FACTOR 39
U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		4 / 6 TYR D 487
LEU D 495
GLU D 532
LEU E 385
 None
 1.30A 5xooA-5uz5D:
undetectable		 5xooA-5uz5D:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLN G 202
PHE G 211
LEU G 215
PHE G 219
 None
 1.01A 5z86C-5uz5G:
undetectable
5z86J-5uz5G:
undetectable		 5z86C-5uz5G:
18.31
5z86J-5uz5G:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLN G 202
PHE G 211
LEU G 215
PHE G 219
 None
 1.01A 5zcpC-5uz5G:
undetectable
5zcpJ-5uz5G:
undetectable		 5zcpC-5uz5G:
18.31
5zcpJ-5uz5G:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 GLN G 202
PHE G 211
LEU G 215
PHE G 219
 None
 1.08A 5zcpP-5uz5G:
undetectable
5zcpW-5uz5G:
undetectable		 5zcpP-5uz5G:
18.31
5zcpW-5uz5G:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42
(Saccharomyces
cerevisiae) 		3 / 3 TYR D 263
PRO D 305
LEU D 304
 None
 0.92A 6beoA-5uz5D:
undetectable		 6beoA-5uz5D:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5uz5 SMALL NUCLEAR
RIBONUCLEOPROTEIN G
(Saccharomyces
cerevisiae) 		5 / 10 GLY Q  31
LEU Q  29
THR Q  61
ALA Q  43
LEU Q  17
 None
 0.90A 6czmA-5uz5Q:
undetectable
6czmC-5uz5Q:
undetectable		 6czmA-5uz5Q:
14.03
6czmC-5uz5Q:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5uz5 SMALL NUCLEAR
RIBONUCLEOPROTEIN G
(Saccharomyces
cerevisiae) 		5 / 10 LEU Q  29
THR Q  61
VAL Q  25
ALA Q  43
LEU Q  17
 None
 0.81A 6czmA-5uz5Q:
undetectable
6czmC-5uz5Q:
undetectable		 6czmA-5uz5Q:
14.03
6czmC-5uz5Q:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 9 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.12A 6ebpA-5uz5G:
undetectable		 6ebpA-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 10 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.10A 6ebpB-5uz5G:
undetectable		 6ebpB-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 10 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.08A 6ebpC-5uz5G:
undetectable		 6ebpC-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 10 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.09A 6ebpD-5uz5G:
undetectable		 6ebpD-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 11 LEU G 117
GLY G  67
ILE G  65
PHE G 224
ILE G  97
 None
 1.07A 6ebzC-5uz5G:
undetectable		 6ebzC-5uz5G:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		5 / 10 ILE G 115
VAL G 203
LEU G  70
LEU G 132
LEU G 133
 None
 0.99A 6f6nA-5uz5G:
undetectable
6f6nB-5uz5G:
undetectable		 6f6nA-5uz5G:
9.55
6f6nB-5uz5G:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
(Saccharomyces
cerevisiae) 		4 / 6 LYS G 204
GLN G 202
PHE G 201
LEU G 215
 None
 1.35A 6nmpC-5uz5G:
undetectable
6nmpJ-5uz5G:
undetectable		 6nmpC-5uz5G:
18.31
6nmpJ-5uz5G:
8.11