SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uz7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 PHE R 313
ASN R 312
GLU R 240
GLY R 241
 None
 0.84A 1ykiA-5uz7R:
undetectable
1ykiB-5uz7R:
undetectable		 1ykiA-5uz7R:
15.32
1ykiB-5uz7R:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 PHE R 313
ASN R 312
GLU R 240
GLY R 241
 None
 0.83A 1ykiA-5uz7R:
undetectable
1ykiB-5uz7R:
undetectable		 1ykiA-5uz7R:
15.32
1ykiB-5uz7R:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 PHE R 313
ASN R 312
GLU R 240
GLY R 241
 None
 0.84A 1ykiC-5uz7R:
undetectable
1ykiD-5uz7R:
undetectable		 1ykiC-5uz7R:
15.32
1ykiD-5uz7R:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 PHE R 313
ASN R 312
GLU R 240
GLY R 241
 None
 0.84A 1ykiC-5uz7R:
undetectable
1ykiD-5uz7R:
undetectable		 1ykiC-5uz7R:
15.32
1ykiD-5uz7R:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 7 PHE R 269
TYR R 228
PRO R 273
THR R 275
 None
 1.28A 2q6kA-5uz7R:
undetectable		 2q6kA-5uz7R:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		3 / 3 GLN R 227
THR R 274
LEU R 193
 None
 0.69A 3ondA-5uz7R:
undetectable		 3ondA-5uz7R:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		3 / 3 GLN R 227
THR R 274
LEU R 193
 None
 0.70A 3ondB-5uz7R:
undetectable		 3ondB-5uz7R:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		3 / 3 HIS R 377
HIS R 381
ILE R 380
 None
 0.59A 3u52A-5uz7R:
undetectable
3u52C-5uz7R:
2.6		 3u52A-5uz7R:
19.02
3u52C-5uz7R:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 TYR R 262
TYR R 243
TRP R 236
ARG R 180
 None
 1.05A 3wipB-5uz7R:
undetectable
3wipC-5uz7R:
undetectable		 3wipB-5uz7R:
17.37
3wipC-5uz7R:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 TYR R 262
TYR R 243
TRP R 236
ARG R 180
 None
 1.07A 3wipC-5uz7R:
undetectable
3wipD-5uz7R:
undetectable		 3wipC-5uz7R:
17.37
3wipD-5uz7R:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 TRP R 236
ARG R 180
TYR R 262
TYR R 243
 None
 1.06A 3wipA-5uz7R:
undetectable
3wipE-5uz7R:
undetectable		 3wipA-5uz7R:
17.37
3wipE-5uz7R:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		3 / 3 TYR R 338
ARG R 328
LYS R 337
 None
 1.32A 4wq5B-5uz7R:
1.5		 4wq5B-5uz7R:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 5 TYR R 234
VAL R 305
PRO R 270
ALA R 308
 None
 1.07A 5otrA-5uz7R:
undetectable		 5otrA-5uz7R:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 6 GLY R 241
LEU R 238
VAL R 320
PHE R 313
 None
 0.96A 6h7lA-5uz7R:
16.3		 6h7lA-5uz7R:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 6 GLY R 241
LEU R 238
VAL R 320
PHE R 313
 None
 0.95A 6h7lB-5uz7R:
16.5		 6h7lB-5uz7R:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5uz7 CALCITONIN RECEPTOR
(Homo
sapiens) 		4 / 8 HIS R 245
GLY R 241
GLY R 353
LEU R 352
 None
 0.83A 6mdqA-5uz7R:
undetectable		 6mdqA-5uz7R:
11.46