SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5uz8 CADHERIN-23
(Mus
musculus) 		5 / 10 PHE A2379
VAL A2470
VAL A2472
ILE A2398
LEU A2418
 None
 1.10A 1fe2A-5uz8A:
undetectable		 1fe2A-5uz8A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 5uz8 CADHERIN-23
(Mus
musculus) 		4 / 7 ILE A2434
TYR A2384
PHE A2379
ASP A2380
 None
 0.80A 2qebA-5uz8A:
undetectable		 2qebA-5uz8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 5uz8 CADHERIN-23
(Mus
musculus) 		4 / 7 ILE A2434
TYR A2384
PHE A2379
ASP A2380
 None
 0.78A 2qebB-5uz8A:
undetectable		 2qebB-5uz8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5uz8 CADHERIN-23
(Mus
musculus) 		3 / 3 TYR A2320
VAL A2342
THR A2336
 None
 0.87A 2ygnA-5uz8A:
2.5		 2ygnA-5uz8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5uz8 CADHERIN-23
(Mus
musculus) 		5 / 9 SER A2504
THR A2507
GLY A2540
ASP A2536
ASP A2538
 None
 1.18A 3sfuA-5uz8A:
undetectable		 3sfuA-5uz8A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5uz8 CADHERIN-23
(Mus
musculus) 		3 / 3 ASN A2373
ASP A2456
ASN A2457
 CA  A2608 (-3.1A)
CA  A2608 (-3.2A)
None
 0.76A 4agaA-5uz8A:
undetectable		 4agaA-5uz8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5uz8 CADHERIN-23
(Mus
musculus) 		3 / 3 GLN A2545
THR A2544
THR A2543
 None
 0.60A 4fu9A-5uz8A:
undetectable		 4fu9A-5uz8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5uz8 CADHERIN-23
(Mus
musculus) 		3 / 3 GLN A2545
THR A2544
THR A2543
 None
 0.59A 4fufA-5uz8A:
undetectable		 4fufA-5uz8A:
undetectable