SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uz9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 300
GLU A 332
ALA A 327
LEU A 325
 None
 1.19A 1eta1-5uz9A:
undetectable		 1eta1-5uz9A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 300
GLU A 332
ALA A 327
LEU A 325
 None
 1.11A 1etb1-5uz9A:
undetectable		 1etb1-5uz9A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 TRP A 263
GLU A 261
ILE B  70
GLY B  30
 None
 0.92A 1maaB-5uz9A:
undetectable
1maaD-5uz9A:
undetectable		 1maaB-5uz9A:
23.37
1maaD-5uz9A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		4 / 6 LEU C 116
LEU C 119
GLY C 120
ILE C 350
 None
 0.83A 1mt1G-5uz9C:
undetectable
1mt1J-5uz9C:
undetectable		 1mt1G-5uz9C:
10.97
1mt1J-5uz9C:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		3 / 3 ARG A 321
ASP B 215
ASN A 237
 None
 0.93A 1nbhD-5uz9A:
undetectable		 1nbhD-5uz9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 331
LEU A 395
ALA A 333
LEU A 334
 None
 1.02A 1nh8A-5uz9A:
undetectable		 1nh8A-5uz9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		4 / 5 LEU C 214
ALA C 154
LEU C 217
SER C 220
 None
 1.10A 1tt6B-5uz9C:
undetectable		 1tt6B-5uz9C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		5 / 11 LEU C  37
LEU C 214
ALA C 154
LEU C 217
SER C 220
 None
 1.24A 1tz8A-5uz9C:
0.0
1tz8B-5uz9C:
undetectable		 1tz8A-5uz9C:
17.11
1tz8B-5uz9C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		5 / 11 LEU C 214
ALA C 154
LEU C 217
SER C 220
LEU C  37
 None
 1.28A 1tz8A-5uz9C:
0.0
1tz8B-5uz9C:
undetectable		 1tz8A-5uz9C:
17.11
1tz8B-5uz9C:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5uz9 ANTI-CRISPR PROTEIN
ACR30-35
(Pseudomonas
phage
JBD30) 		3 / 3 LEU I  57
PRO I  58
ARG I  74
 None
 0.56A 2qd4B-5uz9I:
undetectable		 2qd4B-5uz9I:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		4 / 7 ILE C 350
LEU C 116
LEU C 119
GLY C 120
 None
 0.76A 2qqcD-5uz9C:
undetectable
2qqcE-5uz9C:
undetectable		 2qqcD-5uz9C:
16.86
2qqcE-5uz9C:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 264
LEU A 265
TRP B  29
ILE B  23
 None
 1.06A 2rlfA-5uz9A:
undetectable
2rlfB-5uz9A:
undetectable		 2rlfA-5uz9A:
9.43
2rlfB-5uz9A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 264
LEU A 265
TRP B  29
ILE B  23
 None
 1.04A 2rlfB-5uz9A:
undetectable
2rlfC-5uz9A:
undetectable		 2rlfB-5uz9A:
9.43
2rlfC-5uz9A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
(Pseudomonas
aeruginosa) 		4 / 8 SER A 233
TYR A 235
PRO A 266
LEU A 268
 None
 1.18A 2v0zO-5uz9A:
undetectable		 2v0zO-5uz9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		5 / 12 ILE C 181
LEU C 214
ILE C 218
ALA C 158
LEU C 283
 None
 1.15A 3a50A-5uz9C:
undetectable		 3a50A-5uz9C:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		5 / 10 ALA C 234
LEU C 167
ALA C 174
ILE C 238
LEU C 103
 None
 1.14A 3fl9F-5uz9C:
undetectable		 3fl9F-5uz9C:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 5 ARG B 315
ARG B 189
GLY B 287
GLU B 288
 None
 1.03A 3k9fA-5uz9B:
1.9
3k9fB-5uz9B:
1.9
3k9fC-5uz9B:
undetectable		 3k9fA-5uz9B:
22.29
3k9fB-5uz9B:
22.29
3k9fC-5uz9B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 ARG B 315
ARG B 189
GLY B 287
GLU B 288
 None
 1.03A 3k9fA-5uz9B:
1.9
3k9fB-5uz9B:
1.9
3k9fD-5uz9B:
undetectable		 3k9fA-5uz9B:
22.29
3k9fB-5uz9B:
22.29
3k9fD-5uz9B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		3 / 3 ASN C 281
ALA C 300
ARG C 284
 C  M  38 ( 3.8A)
None
C  M  38 ( 3.2A)
 0.78A 3tj7C-5uz9C:
undetectable
3tj7D-5uz9C:
undetectable		 3tj7C-5uz9C:
19.06
3tj7D-5uz9C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		5 / 12 PHE C 114
ALA C 282
VAL C 232
LEU C 116
ILE C 218
 None
 1.05A 4g1bA-5uz9C:
undetectable		 4g1bA-5uz9C:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		4 / 6 GLU C  34
ARG C  35
ASP C  38
ARG C 117
 U  M  35 ( 4.9A)
A  M  36 ( 4.4A)
None
None
 1.38A 4kcnA-5uz9C:
undetectable		 4kcnA-5uz9C:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 GLY B 117
ASP B 119
GLY B 115
GLU B   7
 None
 0.84A 4koeA-5uz9B:
undetectable
4koeB-5uz9B:
undetectable
4koeD-5uz9B:
undetectable		 4koeA-5uz9B:
22.29
4koeB-5uz9B:
22.29
4koeD-5uz9B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		3 / 3 GLY B 246
PRO B 245
GLN A 324
 None
 0.56A 4oltB-5uz9B:
undetectable		 4oltB-5uz9B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		3 / 3 GLY B 246
PRO B 245
GLN A 324
 None
 0.57A 4qwpB-5uz9B:
undetectable		 4qwpB-5uz9B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 5 ARG B 315
ARG B 189
GLY B 287
GLU B 288
 None
 1.24A 4z3oA-5uz9B:
2.1
4z3oB-5uz9B:
2.0		 4z3oA-5uz9B:
19.40
4z3oB-5uz9B:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 GLY B 117
ASP B 119
GLY B 115
GLU B   7
 None
 0.84A 4z53A-5uz9B:
2.0
4z53B-5uz9B:
2.0		 4z53A-5uz9B:
19.40
4z53B-5uz9B:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ALA B 207
ARG B 189
GLY B 287
GLU B 288
 None
 1.02A 5bs8A-5uz9B:
1.8
5bs8B-5uz9B:
undetectable
5bs8C-5uz9B:
1.8		 5bs8A-5uz9B:
21.59
5bs8B-5uz9B:
23.82
5bs8C-5uz9B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ARG B 189
GLY B 287
GLU B 288
ARG B 315
 None
 1.02A 5bs8A-5uz9B:
1.8
5bs8B-5uz9B:
undetectable
5bs8C-5uz9B:
1.8		 5bs8A-5uz9B:
21.59
5bs8B-5uz9B:
23.82
5bs8C-5uz9B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ARG B 315
ARG B 189
GLY B 287
GLU B 288
 None
 0.97A 5btaA-5uz9B:
1.6
5btaC-5uz9B:
1.7
5btaD-5uz9B:
undetectable		 5btaA-5uz9B:
21.59
5btaC-5uz9B:
21.59
5btaD-5uz9B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 ARG B 189
GLY B 287
GLU B 288
ARG B 315
 None
 0.98A 5btaA-5uz9B:
undetectable
5btaB-5uz9B:
undetectable
5btaC-5uz9B:
undetectable		 5btaA-5uz9B:
21.59
5btaB-5uz9B:
23.82
5btaC-5uz9B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 ARG B 315
ARG B 189
GLY B 287
GLU B 288
 None
 1.02A 5btcA-5uz9B:
undetectable
5btcC-5uz9B:
1.7
5btcD-5uz9B:
undetectable		 5btcA-5uz9B:
21.59
5btcC-5uz9B:
21.59
5btcD-5uz9B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 6 ARG B 189
GLY B 287
GLU B 288
ARG B 315
 None
 1.02A 5btcA-5uz9B:
undetectable
5btcB-5uz9B:
undetectable
5btcC-5uz9B:
1.7		 5btcA-5uz9B:
21.59
5btcB-5uz9B:
23.82
5btcC-5uz9B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  95
ARG B 189
GLY B 287
GLU B 288
 None
 0.98A 5btdA-5uz9A:
undetectable
5btdB-5uz9A:
undetectable
5btdC-5uz9A:
undetectable		 5btdA-5uz9A:
23.75
5btdB-5uz9A:
19.82
5btdC-5uz9A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ALA B 207
ARG B 189
GLY B 287
GLU B 288
 None
 1.00A 5btdA-5uz9B:
1.8
5btdB-5uz9B:
undetectable
5btdC-5uz9B:
undetectable		 5btdA-5uz9B:
21.59
5btdB-5uz9B:
23.82
5btdC-5uz9B:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ALA B 207
ARG B 189
GLY B 287
GLU B 288
 None
 0.98A 5btdA-5uz9B:
1.8
5btdC-5uz9B:
undetectable
5btdD-5uz9B:
undetectable		 5btdA-5uz9B:
21.59
5btdC-5uz9B:
21.59
5btdD-5uz9B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 7 ARG B 315
ARG B 189
GLY B 287
GLU B 288
 None
 1.01A 5btfA-5uz9B:
1.6
5btfC-5uz9B:
1.8
5btfD-5uz9B:
undetectable		 5btfA-5uz9B:
21.59
5btfC-5uz9B:
21.59
5btfD-5uz9B:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 5 ARG B 189
GLY B 287
GLU B 288
ARG B 315
 None
 0.89A 5cdqA-5uz9B:
undetectable
5cdqB-5uz9B:
undetectable
5cdqC-5uz9B:
undetectable		 5cdqA-5uz9B:
24.58
5cdqB-5uz9B:
23.10
5cdqC-5uz9B:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY2
(Pseudomonas
aeruginosa) 		4 / 5 ARG B 189
GLY B 287
GLU B 288
ARG B 315
 None
 0.86A 5cdqR-5uz9B:
undetectable
5cdqS-5uz9B:
undetectable
5cdqT-5uz9B:
undetectable		 5cdqR-5uz9B:
24.58
5cdqS-5uz9B:
23.10
5cdqT-5uz9B:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		4 / 5 ALA C 273
PRO C  39
GLY C 221
LEU C 161
 None
 0.78A 5eslA-5uz9C:
undetectable		 5eslA-5uz9C:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 178
PRO A 192
ILE A  73
LEU A 174
 U  M   2 ( 4.3A)
A  M   3 ( 4.8A)
A  M   3 ( 4.3A)
G  M   5 ( 4.8A)
 1.06A 5fxtA-5uz9A:
undetectable		 5fxtA-5uz9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		6 / 11 ALA C  46
THR C 109
ALA C  48
VAL C  61
GLY C 241
ASP C 106
 None
 1.47A 5lf7K-5uz9C:
undetectable
5lf7L-5uz9C:
undetectable		 5lf7K-5uz9C:
22.32
5lf7L-5uz9C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY3
(Pseudomonas
aeruginosa) 		6 / 11 ALA C  46
THR C 109
ALA C  48
VAL C  61
GLY C 241
ASP C 106
 None
 1.45A 5lf7Y-5uz9C:
undetectable
5lf7Z-5uz9C:
undetectable		 5lf7Y-5uz9C:
22.32
5lf7Z-5uz9C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
(Pseudomonas
aeruginosa) 		4 / 7 HIS A  83
THR A 163
HIS A 201
ASP A 107
 None
 1.09A 6mn4E-5uz9A:
undetectable		 6mn4E-5uz9A:
21.91