SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uze'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 12 ALA A  47
PHE A 362
ILE A 345
LEU A 430
ILE A 361
THR A  53
 IMP  A 500 (-3.6A)
None
None
None
None
None
 1.37A 1drbB-5uzeA:
undetectable		 1drbB-5uzeA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 11 ASN A 275
GLY A 298
CYH A 303
THR A 305
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
IMP  A 500 ( 3.1A)
 0.38A 1jr1A-5uzeA:
52.0		 1jr1A-5uzeA:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 8 ASN A 275
GLY A 298
THR A 305
GLY A 387
 IMP  A 500 (-4.0A)
None
8L1  A 501 (-3.9A)
IMP  A 500 ( 3.1A)
 0.27A 1jr1B-5uzeA:
51.7		 1jr1B-5uzeA:
33.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 8 ASN A 275
ILE A 297
GLY A 298
CYH A 303
GLY A 387
 IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
IMP  A 500 ( 3.1A)
 0.45A 1me7A-5uzeA:
48.2		 1me7A-5uzeA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 TYR A 383
GLY A 359
ALA A  47
SER A  48
ILE A 361
 IMP  A 500 (-4.8A)
IMP  A 500 (-3.5A)
IMP  A 500 (-3.6A)
None
None
 1.18A 1nt2A-5uzeA:
undetectable		 1nt2A-5uzeA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 6 LEU A 217
VAL A 295
ILE A 272
MET A  61
 None
 1.25A 2hyyB-5uzeA:
undetectable		 2hyyB-5uzeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 10 LEU A 316
ALA A 353
ILE A 334
VAL A 295
GLY A 326
 None
 0.92A 3ogqA-5uzeA:
undetectable		 3ogqA-5uzeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 ILE A 345
LEU A 339
ALA A 335
PRO A  43
ILE A  42
 None
 1.03A 3vrmA-5uzeA:
undetectable		 3vrmA-5uzeA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 4 SER A 301
TYR A 383
GLY A 337
PRO A 299
 IMP  A 500 (-2.5A)
IMP  A 500 (-4.8A)
IMP  A 500 (-3.4A)
None
 1.46A 4e3aA-5uzeA:
3.0		 4e3aA-5uzeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 4 SER A 301
TYR A 383
GLY A 338
PRO A 299
 IMP  A 500 (-2.5A)
IMP  A 500 (-4.8A)
IMP  A 500 (-3.4A)
None
 1.31A 4e3aA-5uzeA:
3.0		 4e3aA-5uzeA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 12 ALA A  47
PHE A 362
ILE A 345
LEU A 430
ILE A 361
THR A  53
 IMP  A 500 (-3.6A)
None
None
None
None
None
 1.44A 4fhbA-5uzeA:
undetectable		 4fhbA-5uzeA:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 8 ASP A 246
ASN A 275
CYH A 303
THR A 305
MET A 386
GLY A 387
 None
IMP  A 500 (-4.0A)
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.38A 4fo4A-5uzeA:
55.5		 4fo4A-5uzeA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 8 ASN A 275
GLY A 298
CYH A 303
THR A 305
MET A 386
GLY A 387
 IMP  A 500 (-4.0A)
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
None
IMP  A 500 ( 3.1A)
 0.27A 4fo4B-5uzeA:
55.0		 4fo4B-5uzeA:
62.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 9 ASN A 275
ILE A 297
GLY A 298
CYH A 303
THR A 305
ASP A 336
 IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
IMP  A 500 (-2.4A)
 0.32A 4fxsA-5uzeA:
54.3		 4fxsA-5uzeA:
45.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		6 / 9 ASP A 246
ASN A 275
ILE A 297
GLY A 298
CYH A 303
THR A 305
 None
IMP  A 500 (-4.0A)
None
None
IMP  A 500 (-3.1A)
8L1  A 501 (-3.9A)
 0.77A 4fxsA-5uzeA:
54.3		 4fxsA-5uzeA:
45.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 6 ARG A  63
GLY A  65
ALA A 424
GLU A  64
 None
 1.06A 4g0uA-5uzeA:
undetectable		 4g0uA-5uzeA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.87A 4txnA-5uzeA:
undetectable		 4txnA-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.89A 4txnB-5uzeA:
undetectable		 4txnB-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.91A 4txnC-5uzeA:
undetectable		 4txnC-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.89A 4txnD-5uzeA:
undetectable		 4txnD-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 VAL A 232
GLY A 258
TYR A 266
ILE A 256
SER A 252
 None
None
None
None
8L1  A 501 (-3.6A)
 1.29A 4xudA-5uzeA:
undetectable		 4xudA-5uzeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 ILE A 272
MET A  45
MET A 357
ALA A 335
ASN A 275
 None
None
IMP  A 500 ( 3.8A)
None
IMP  A 500 (-4.0A)
 1.47A 4zo1X-5uzeA:
undetectable		 4zo1X-5uzeA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 10 LEU A 329
ALA A 290
ILE A 272
GLY A 274
ILE A 331
 None
 0.96A 5kr1A-5uzeA:
undetectable		 5kr1A-5uzeA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 10 ILE A 434
ASN A  19
LEU A 349
ALA A 453
GLU A  22
 None
 1.06A 5y7pG-5uzeA:
undetectable		 5y7pG-5uzeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 LEU A  44
ILE A 345
ILE A 361
MET A 358
LEU A  15
 None
 0.88A 5ycnA-5uzeA:
undetectable		 5ycnA-5uzeA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 7 VAL A  86
PRO A  43
LEU A  30
MET A 358
 None
 0.87A 6aycA-5uzeA:
undetectable		 6aycA-5uzeA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		5 / 12 LEU A  15
GLY A 343
GLY A 433
ASN A  19
PRO A  18
 None
 1.12A 6ce2B-5uzeA:
undetectable		 6ce2B-5uzeA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Clostridium
perfringens) 		4 / 6 PRO A  43
ILE A 427
GLY A  66
GLU A  64
 None
 1.00A 6gqiA-5uzeA:
undetectable		 6gqiA-5uzeA:
20.65