SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5uzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 VAL A 199
ALA A 189
GLY A 213
LEU A 341
TYR A 160
 None
 1.06A 1kiaC-5uzhA:
6.8		 1kiaC-5uzhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 VAL A 199
ALA A 189
GLY A 213
LEU A 341
TYR A 160
 None
 1.07A 1nbhB-5uzhA:
6.6		 1nbhB-5uzhA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 10 ALA A 299
ALA A 297
VAL A 228
LEU A 249
PHE A 360
 None
None
GDP  A 401 (-3.7A)
GDP  A 401 (-3.9A)
None
 1.17A 1rlbE-5uzhA:
undetectable		 1rlbE-5uzhA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 10 ALA A  36
TYR A 115
LEU A  37
GLY A  62
GLY A  40
 None
None
None
None
NAP  A 402 (-3.2A)
 1.33A 1ruaH-5uzhA:
undetectable
1ruaL-5uzhA:
undetectable		 1ruaH-5uzhA:
20.56
1ruaL-5uzhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUL_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 9 ALA A  36
TYR A 115
LEU A  37
GLY A  62
GLY A  40
 None
None
None
None
NAP  A 402 (-3.2A)
 1.33A 1rulH-5uzhA:
undetectable
1rulL-5uzhA:
undetectable		 1rulH-5uzhA:
20.56
1rulL-5uzhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.07A 2h77A-5uzhA:
undetectable		 2h77A-5uzhA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.09A 2h79A-5uzhA:
undetectable		 2h79A-5uzhA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		3 / 3 VAL A 123
ASN A 217
TRP A 258
 GDP  A 401 (-4.1A)
GDP  A 401 ( 3.4A)
None
 1.10A 2y00B-5uzhA:
undetectable		 2y00B-5uzhA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.09A 3gwsX-5uzhA:
undetectable		 3gwsX-5uzhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 GLU A 113
ILE A 114
PHE A 159
ALA A  36
ILE A 106
 None
 1.20A 3ndiA-5uzhA:
4.8		 3ndiA-5uzhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 LEU A  37
TYR A 115
ALA A  50
GLY A  46
GLY A  62
 None
 1.12A 3ou7A-5uzhA:
undetectable		 3ou7A-5uzhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 11 ILE A 239
ILE A 232
ILE A 301
VAL A 326
VAL A 320
 None
 1.09A 3tmzA-5uzhA:
undetectable		 3tmzA-5uzhA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 11 GLY A  40
PRO A 111
ILE A 106
LEU A 144
ILE A 114
 NAP  A 402 (-3.2A)
None
None
None
None
 1.07A 4dt8A-5uzhA:
undetectable		 4dt8A-5uzhA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.10A 4lnwA-5uzhA:
undetectable		 4lnwA-5uzhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 ILE A  82
ALA A  87
ALA A  50
LEU A  78
ILE A  41
 None
 1.09A 4lnxA-5uzhA:
undetectable		 4lnxA-5uzhA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_C_3CJC607_1
(LACTOPEROXIDASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		4 / 6 GLN A 244
ASP A 245
ARG A 325
ARG A 327
 None
 1.43A 4qyqC-5uzhA:
undetectable		 4qyqC-5uzhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		4 / 7 ILE A  38
LEU A 117
GLY A  43
GLY A  46
 None
NAP  A 402 (-4.3A)
NAP  A 402 (-3.4A)
None
 0.86A 5a06B-5uzhA:
6.5		 5a06B-5uzhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 10 LEU A  49
GLU A 113
LEU A 272
MET A 271
GLY A 213
 None
 1.31A 5dxbA-5uzhA:
undetectable		 5dxbA-5uzhA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_C_3CJC609_1
(LACTOPEROXIDASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		4 / 6 GLN A 244
ASP A 245
ARG A 325
ARG A 327
 None
 1.43A 5hpwC-5uzhA:
undetectable		 5hpwC-5uzhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		5 / 12 ILE A 198
ASP A 137
GLY A 138
THR A  99
ALA A 162
 None
None
None
None
NAP  A 402 (-3.3A)
 1.22A 5x5qB-5uzhA:
undetectable		 5x5qB-5uzhA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		4 / 7 ARG A 334
THR A 336
PRO A 335
PRO A 187
 GDP  A 401 (-3.1A)
None
None
None
 1.32A 6a4iB-5uzhA:
undetectable		 6a4iB-5uzhA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5uzh NAFOA.00085.B
(Naegleria
fowleri) 		3 / 3 ARG A 334
ARG A 223
ARG A 256
 GDP  A 401 (-3.1A)
NAP  A 402 (-3.3A)
GDP  A 401 (-3.4A)
 0.97A 6bplA-5uzhA:
undetectable
6bplB-5uzhA:
undetectable		 6bplA-5uzhA:
13.04
6bplB-5uzhA:
13.04