SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 9 GLY Z 223
PHE Z 275
TYR Z 217
ILE Z 276
GLY Z 274
 NA  Z 403 ( 4.4A)
None
None
None
None
 1.42A 1acjA-5v07Z:
undetectable		 1acjA-5v07Z:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		4 / 7 ILE Z 125
LEU Z 155
ILE Z  74
PHE Z  77
 None
 0.86A 1uwjA-5v07Z:
undetectable		 1uwjA-5v07Z:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		4 / 5 LEU Z  35
GLY Z  38
ILE Z 123
ILE Z 125
 None
 0.83A 2q9rA-5v07Z:
undetectable		 2q9rA-5v07Z:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TOD_B_DMOB700_1
(PROTEIN (ORNITHINE
DECARBOXYLASE))		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		4 / 5 ASP Z 225
TYR Z 226
ASP Z 152
PHE Z 177
 None
None
MN  Z 401 ( 2.8A)
None
 1.44A 2todA-5v07Z:
undetectable
2todB-5v07Z:
undetectable		 2todA-5v07Z:
23.45
2todB-5v07Z:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 11 PHE Z 215
SER Z 222
LEU Z   7
ILE Z 195
ASP Z 171
 None
None
None
None
MN  Z 401 (-2.7A)
 1.27A 3ko0A-5v07Z:
undetectable
3ko0B-5v07Z:
undetectable
3ko0C-5v07Z:
undetectable
3ko0D-5v07Z:
undetectable		 3ko0A-5v07Z:
14.45
3ko0B-5v07Z:
14.45
3ko0C-5v07Z:
14.45
3ko0D-5v07Z:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 11 ASP Z 171
LEU Z   7
ILE Z 195
PHE Z 215
SER Z 222
 MN  Z 401 (-2.7A)
None
None
None
None
 1.30A 3ko0E-5v07Z:
undetectable
3ko0F-5v07Z:
undetectable
3ko0G-5v07Z:
undetectable
3ko0H-5v07Z:
undetectable		 3ko0E-5v07Z:
14.45
3ko0F-5v07Z:
14.45
3ko0G-5v07Z:
14.45
3ko0H-5v07Z:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 12 SER Z 222
PHE Z 215
LEU Z   7
ILE Z 195
ASP Z 171
 None
None
None
None
MN  Z 401 (-2.7A)
 1.26A 3ko0G-5v07Z:
undetectable
3ko0H-5v07Z:
undetectable
3ko0I-5v07Z:
undetectable
3ko0J-5v07Z:
undetectable		 3ko0G-5v07Z:
14.45
3ko0H-5v07Z:
14.45
3ko0I-5v07Z:
14.45
3ko0J-5v07Z:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 11 SER Z 222
PHE Z 215
ASP Z 171
LEU Z   7
ILE Z 195
 None
None
MN  Z 401 (-2.7A)
None
None
 1.32A 3ko0Q-5v07Z:
undetectable
3ko0R-5v07Z:
undetectable
3ko0S-5v07Z:
undetectable
3ko0T-5v07Z:
undetectable		 3ko0Q-5v07Z:
14.45
3ko0R-5v07Z:
14.45
3ko0S-5v07Z:
14.45
3ko0T-5v07Z:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_F_P77F203_1
(PROTEIN S100-A4)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 9 ASP Z 171
ILE Z 195
PHE Z 177
PHE Z 215
SER Z 222
 MN  Z 401 (-2.7A)
None
None
None
None
 1.20A 3m0wC-5v07Z:
undetectable
3m0wD-5v07Z:
undetectable
3m0wE-5v07Z:
undetectable
3m0wF-5v07Z:
undetectable		 3m0wC-5v07Z:
14.16
3m0wD-5v07Z:
14.16
3m0wE-5v07Z:
14.16
3m0wF-5v07Z:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 10 PHE Z 215
ALA Z 176
PHE Z 177
GLY Z 178
CYH Z 203
 None
 1.42A 3qpsA-5v07Z:
undetectable		 3qpsA-5v07Z:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 11 ILE Z 257
ILE Z 233
GLY Z 232
GLY Z 223
ARG Z 277
 None
None
None
NA  Z 403 ( 4.4A)
None
 0.98A 4ac9B-5v07Z:
2.3
4ac9C-5v07Z:
2.1		 4ac9B-5v07Z:
20.51
4ac9C-5v07Z:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		5 / 12 ALA Z 115
GLY Z 103
ASN Z 124
GLN Z  97
GLU Z  94
 None
 1.25A 5nwuA-5v07Z:
undetectable		 5nwuA-5v07Z:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 5v07 EXONUCLEASE 1
(Homo
sapiens) 		3 / 3 HIS Z 131
ARG Z 138
ILE Z 134
 None
 0.84A 6fgdA-5v07Z:
2.2		 6fgdA-5v07Z:
22.02