SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 GLU A 211
ILE A 249
LEU A 246
SER A 215
ILE A 207
 None
 1.23A 2e7fB-5v0iA:
undetectable		 2e7fB-5v0iA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 7 PHE A  80
ALA A 313
ALA A 317
THR A 320
LEU A  91
 None
 1.38A 2wx2A-5v0iA:
undetectable		 2wx2A-5v0iA:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.45A 3fhjA-5v0iA:
40.0		 3fhjA-5v0iA:
56.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.42A 3fhjB-5v0iA:
38.2		 3fhjB-5v0iA:
56.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.41A 3fhjC-5v0iA:
37.1		 3fhjC-5v0iA:
56.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.43A 3fhjD-5v0iA:
38.5		 3fhjD-5v0iA:
56.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.44A 3fhjE-5v0iA:
39.2		 3fhjE-5v0iA:
56.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.43A 3fhjF-5v0iA:
39.8		 3fhjF-5v0iA:
56.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.54A 3fi0A-5v0iA:
38.8		 3fi0A-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
VAL A 144
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
 1.14A 3fi0A-5v0iA:
38.8		 3fi0A-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 8 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.45A 3fi0B-5v0iA:
38.4		 3fi0B-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.50A 3fi0C-5v0iA:
39.0		 3fi0C-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
 0.60A 3fi0D-5v0iA:
39.8		 3fi0D-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.49A 3fi0D-5v0iA:
39.8		 3fi0D-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		7 / 7 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
TRP  A 402 (-3.1A)
 0.48A 3fi0E-5v0iA:
37.8		 3fi0E-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
 0.55A 3fi0F-5v0iA:
29.3		 3fi0F-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
VAL A 144
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
None
 1.08A 3fi0F-5v0iA:
29.3		 3fi0F-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.49A 3fi0F-5v0iA:
29.3		 3fi0F-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		7 / 8 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
TRP  A 402 (-3.1A)
 0.31A 3fi0G-5v0iA:
40.0		 3fi0G-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		6 / 8 HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.57A 3fi0G-5v0iA:
40.0		 3fi0G-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.52A 3fi0H-5v0iA:
39.8		 3fi0H-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
 0.61A 3fi0J-5v0iA:
30.4		 3fi0J-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
VAL A 144
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
None
 1.12A 3fi0J-5v0iA:
30.4		 3fi0J-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.53A 3fi0J-5v0iA:
30.4		 3fi0J-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.50A 3fi0K-5v0iA:
38.7		 3fi0K-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.58A 3fi0L-5v0iA:
39.7		 3fi0L-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.55A 3fi0M-5v0iA:
39.4		 3fi0M-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.52A 3fi0N-5v0iA:
39.5		 3fi0N-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.51A 3fi0O-5v0iA:
39.6		 3fi0O-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		7 / 7 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
TRP  A 402 (-3.1A)
 0.31A 3fi0P-5v0iA:
38.6		 3fi0P-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		8 / 8 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
 0.45A 3fi0Q-5v0iA:
39.7		 3fi0Q-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
None
None
TRP  A 402 (-3.1A)
 0.64A 3fi0R-5v0iA:
37.1		 3fi0R-5v0iA:
57.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
VAL A 144
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.9A)
None
 1.08A 3fi0R-5v0iA:
37.1		 3fi0R-5v0iA:
57.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 10 ALA A 252
VAL A 186
ALA A 278
ILE A 220
LEU A 189
 None
AMP  A 401 (-4.0A)
None
None
None
 1.07A 3fl9A-5v0iA:
undetectable		 3fl9A-5v0iA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 LEU A  25
ASN A  20
GLY A  23
GLN A  27
ILE A  18
 None
AMP  A 401 (-3.4A)
AMP  A 401 (-3.5A)
None
None
 1.40A 3h52A-5v0iA:
undetectable		 3h52A-5v0iA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_C_TPFC490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 PHE A  80
ALA A 313
ALA A 317
THR A 320
LEU A  91
 None
 1.34A 3l4dC-5v0iA:
undetectable		 3l4dC-5v0iA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BB2_B_STRB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 11 ALA A 252
SER A 251
THR A  17
ASN A 245
SER A 188
 None
 1.21A 4bb2A-5v0iA:
undetectable
4bb2B-5v0iA:
undetectable		 4bb2A-5v0iA:
21.43
4bb2B-5v0iA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		4 / 6 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.51A 4f3tA-5v0iA:
undetectable		 4f3tA-5v0iA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 GLY A  19
GLY A  23
ILE A 249
ALA A 252
MET A 196
 AMP  A 401 (-3.6A)
AMP  A 401 (-3.5A)
None
None
None
 1.06A 4kicA-5v0iA:
undetectable		 4kicA-5v0iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 12 GLY A  19
GLY A  23
ILE A 249
ALA A 252
MET A 196
 AMP  A 401 (-3.6A)
AMP  A 401 (-3.5A)
None
None
None
 1.03A 4kicB-5v0iA:
undetectable		 4kicB-5v0iA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		4 / 7 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.56A 4z4fA-5v0iA:
undetectable		 4z4fA-5v0iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		4 / 5 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.56A 5ki6A-5v0iA:
undetectable		 5ki6A-5v0iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		4 / 7 GLY A 183
ALA A 184
ASP A 248
GLY A 255
 None
 0.53A 5kqyB-5v0iA:
undetectable		 5kqyB-5v0iA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		4 / 7 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.57A 5t7bA-5v0iA:
undetectable		 5t7bA-5v0iA:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
TRP  A 402 (-3.1A)
 0.09A 5v0iA-5v0iA:
51.7		 5v0iA-5v0iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
None
 1.20A 5v0iA-5v0iA:
51.7		 5v0iA-5v0iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.2A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
TRP  A 402 (-3.9A)
None
None
TRP  A 402 (-3.1A)
 0.10A 5v0iB-5v0iA:
46.9		 5v0iB-5v0iA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
VAL A 146
 TRP  A 402 (-3.7A)
TRP  A 402 (-4.7A)
TRP  A 402 (-3.6A)
TRP  A 402 (-3.5A)
None
 1.24A 5v0iB-5v0iA:
46.9		 5v0iB-5v0iA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		4 / 6 ALA A  10
GLN A  11
GLN A 150
ASP A 149
 None
TRP  A 402 (-4.2A)
TRP  A 402 (-3.1A)
AMP  A 401 ( 4.9A)
 1.46A 5y9aA-5v0iA:
undetectable		 5y9aA-5v0iA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5v0i TRYPTOPHAN--TRNA
LIGASE
(Escherichia
coli) 		3 / 3 SER A 199
LYS A 198
SER A 197
 None
AMP  A 401 (-4.6A)
None
 0.84A 6az3P-5v0iA:
undetectable		 6az3P-5v0iA:
15.64