SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 PRO C 427
VAL C 348
VAL C 370
GLY C 345
LEU C 457
 None
 1.41A 1fkpA-5v12C:
2.2		 1fkpA-5v12C:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 GLY C 199
VAL C 194
ALA C 437
MET C 197
SER C 440
 None
None
None
FMT  C 501 ( 4.9A)
None
 1.32A 1kiaD-5v12C:
undetectable		 1kiaD-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 PRO C 427
VAL C 348
VAL C 370
GLY C 345
LEU C 457
 None
 1.30A 1lwcA-5v12C:
2.0		 1lwcA-5v12C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 GLY C 199
VAL C 194
ALA C 437
MET C 197
SER C 440
 None
None
None
FMT  C 501 ( 4.9A)
None
 1.32A 1nbhA-5v12C:
undetectable		 1nbhA-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 GLY C 199
VAL C 194
ALA C 437
MET C 197
SER C 440
 None
None
None
FMT  C 501 ( 4.9A)
None
 1.31A 1nbhC-5v12C:
undetectable		 1nbhC-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 GLY C 199
VAL C 194
ALA C 437
MET C 197
SER C 440
 None
None
None
FMT  C 501 ( 4.9A)
None
 1.31A 1nbhD-5v12C:
undetectable		 1nbhD-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 PHE C 204
GLU C 235
ARG C 201
ILE C 233
 None
 1.42A 1nsiA-5v12C:
undetectable
1nsiB-5v12C:
undetectable		 1nsiA-5v12C:
12.90
1nsiB-5v12C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 5 LEU C  43
TRP C 248
MET C 337
LEU C 340
 None
EXA  C 247 ( 3.9A)
None
None
 1.28A 1p93D-5v12C:
undetectable		 1p93D-5v12C:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 ARG C 201
PHE C 202
ILE C 191
PHE C 130
 None
 1.23A 2qeiA-5v12C:
undetectable		 2qeiA-5v12C:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 5 LEU C  36
ILE C  51
PRO C  52
PHE C 250
 None
 1.15A 3s3vA-5v12C:
undetectable		 3s3vA-5v12C:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 9 GLY C 225
VAL C 229
GLU C 330
SER C 243
VAL C 193
 None
 1.25A 4da6A-5v12C:
undetectable		 4da6A-5v12C:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		6 / 11 ARG C 323
GLY C 225
VAL C 229
GLU C 330
SER C 243
VAL C 193
 None
 1.46A 4danA-5v12C:
2.6		 4danA-5v12C:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		6 / 12 ARG C 323
GLY C 225
VAL C 229
GLU C 330
SER C 243
VAL C 193
 None
 1.47A 4danA-5v12C:
2.6
4danB-5v12C:
undetectable		 4danA-5v12C:
17.08
4danB-5v12C:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.45A 4eilA-5v12C:
2.9		 4eilA-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 ILE C 268
THR C 112
VAL C 262
ASP C 237
 None
 1.08A 4iaqA-5v12C:
undetectable		 4iaqA-5v12C:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 7 ILE C 268
THR C 112
VAL C 262
ASP C 237
 None
 1.12A 4iarA-5v12C:
undetectable		 4iarA-5v12C:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.45A 4kyaA-5v12C:
2.9		 4kyaA-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.47A 4kyaD-5v12C:
undetectable		 4kyaD-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.44A 4kyaE-5v12C:
undetectable		 4kyaE-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.45A 4kyaF-5v12C:
undetectable		 4kyaF-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.42A 4kyaG-5v12C:
2.4		 4kyaG-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 ALA C 106
SER C  47
MET C 228
ARG C 438
THR C 107
 EXA  C 247 ( 3.5A)
FMT  C 501 (-3.2A)
None
FMT  C 501 (-3.2A)
EXA  C 247 ( 3.5A)
 1.48A 4kyaH-5v12C:
undetectable		 4kyaH-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 12 VAL C 190
ALA C 189
TYR C 129
SER C 154
ASP C 221
 None
None
None
None
EXA  C 247 ( 3.0A)
 1.27A 4mm4A-5v12C:
undetectable		 4mm4A-5v12C:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 7 PHE C 204
GLU C 235
ARG C 201
ILE C 233
 None
 1.44A 4nosA-5v12C:
undetectable
4nosB-5v12C:
undetectable		 4nosA-5v12C:
11.68
4nosB-5v12C:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 7 ARG C 201
ILE C 233
PHE C 204
GLU C 235
 None
 1.46A 4nosC-5v12C:
undetectable
4nosD-5v12C:
undetectable		 4nosC-5v12C:
11.68
4nosD-5v12C:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NOS_D_H4BD3011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 PHE C 204
GLU C 235
ARG C 201
ILE C 233
 None
 1.40A 4nosC-5v12C:
undetectable
4nosD-5v12C:
undetectable		 4nosC-5v12C:
11.68
4nosD-5v12C:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 LEU C 399
LEU C 352
ARG C 434
PHE C 376
 None
 1.22A 4uswA-5v12C:
undetectable		 4uswA-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 LYS C 339
GLU C 343
GLY C 344
GLY C 345
 None
 1.02A 5a06D-5v12C:
undetectable		 5a06D-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 11 ALA C  88
ALA C  90
VAL C 100
LEU C 249
VAL C 257
 None
 1.15A 5eb5A-5v12C:
undetectable		 5eb5A-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		5 / 10 ALA C  88
ALA C  90
VAL C 100
LEU C 249
VAL C 257
 None
 1.22A 5eb5B-5v12C:
undetectable		 5eb5B-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE
(Neurospora
crassa) 		4 / 6 CYH C 315
LEU C  59
CYH C 255
HIS C 246
 None
None
None
EXA  C 247 ( 4.1A)
 1.13A 5hpuC-5v12C:
undetectable
5hpuD-5v12C:
undetectable		 5hpuC-5v12C:
undetectable
5hpuD-5v12C:
undetectable