SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v1b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		4 / 7 ILE A 253
ASP A 345
LEU A 198
GLY A 203
 None
 0.83A 1rtsB-5v1bA:
undetectable		 1rtsB-5v1bA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 11 HIS A 297
ASP A 299
HIS A 358
VAL A 360
ARG A 367
 FE  A 503 ( 3.6A)
FE  A 503 (-2.7A)
FE  A 503 ( 3.5A)
8UY  A 504 (-4.8A)
8UY  A 504 (-4.1A)
 1.23A 1uofA-5v1bA:
10.7		 1uofA-5v1bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 11 HIS A 297
ASP A 299
THR A 309
HIS A 358
VAL A 360
 FE  A 503 ( 3.6A)
FE  A 503 (-2.7A)
None
FE  A 503 ( 3.5A)
8UY  A 504 (-4.8A)
 0.57A 1uofA-5v1bA:
10.7		 1uofA-5v1bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 10 GLU A 209
ILE A 253
ASP A 345
LEU A 198
GLY A 203
 None
 1.50A 2tsrC-5v1bA:
undetectable		 2tsrC-5v1bA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 12 GLY A 305
PHE A 350
LEU A 389
ASP A 304
ALA A 390
 None
 1.20A 3d91A-5v1bA:
undetectable		 3d91A-5v1bA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 12 PHE A 350
CYH A 310
THR A 371
VAL A 263
ILE A 308
 None
 1.18A 3sp9A-5v1bA:
undetectable		 3sp9A-5v1bA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		4 / 7 ILE A 191
LEU A 348
ALA A 338
VAL A 337
 None
 0.81A 4g77A-5v1bA:
undetectable		 4g77A-5v1bA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		4 / 7 ILE A 253
ASP A 345
LEU A 198
GLY A 203
 None
 0.81A 4iqqC-5v1bA:
undetectable		 4iqqC-5v1bA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 12 GLY A 245
LEU A 256
VAL A 243
VAL A 284
VAL A 210
 None
 1.15A 5dpdA-5v1bA:
undetectable		 5dpdA-5v1bA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 12 GLY A 245
LEU A 256
VAL A 243
VAL A 284
VAL A 210
 None
 1.10A 5dpdB-5v1bA:
undetectable		 5dpdB-5v1bA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		5 / 9 CYH A 250
GLY A 254
GLY A 245
ALA A 282
VAL A 243
 None
 1.44A 5v3cA-5v1bA:
undetectable		 5v3cA-5v1bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		4 / 8 GLN A 393
GLY A 392
TRP A 373
ASP A 304
 None
SO4  A 501 ( 3.8A)
None
None
 1.05A 5vlmD-5v1bA:
undetectable		 5vlmD-5v1bA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5v1b EGL NINE HOMOLOG 2
(Homo
sapiens) 		4 / 7 ILE A 253
ASP A 345
LEU A 198
GLY A 203
 None
 0.82A 5x5qC-5v1bA:
undetectable		 5x5qC-5v1bA:
21.96