SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 ALA A 174
LEU A 144
ALA A 147
ILE A 356
ILE A 157
 None
 0.83A 1fk6A-5v1sA:
undetectable		 1fk6A-5v1sA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 10 THR A 185
ILE A 184
LEU A 233
THR A 195
ILE A 198
 SAM  A 604 (-3.8A)
None
None
None
None
 1.35A 1i18A-5v1sA:
undetectable
1i18B-5v1sA:
undetectable		 1i18A-5v1sA:
11.11
1i18B-5v1sA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 8 LEU A  38
GLU A  34
ILE A  70
TYR A  71
 None
 0.84A 1qvtA-5v1sA:
undetectable		 1qvtA-5v1sA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 7 GLU A 161
THR A 185
SER A 210
VAL A 249
 SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.49A 1tv8A-5v1sA:
21.8		 1tv8A-5v1sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 7 GLU A 161
THR A 185
SER A 210
VAL A 249
 SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.39A 1tv8B-5v1sA:
22.1		 1tv8B-5v1sA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 8 CYH A 124
GLU A 161
THR A 185
SER A 210
VAL A 249
 SF4  A 601 ( 2.2A)
SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.71A 2fb2A-5v1sA:
22.0		 2fb2A-5v1sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 7 GLU A 161
THR A 185
SER A 210
VAL A 249
 SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.43A 2fb2B-5v1sA:
22.0		 2fb2B-5v1sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 8 HIS A  44
ALA A  49
LEU A  87
THR A  86
 None
 0.77A 2it4A-5v1sA:
undetectable		 2it4A-5v1sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 ILE A 111
LEU A 171
ASN A 170
VAL A 155
GLU A 177
 None
 1.23A 2vn0A-5v1sA:
undetectable		 2vn0A-5v1sA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 5v1s RADICAL SAM
(Streptococcus
suis) 		3 / 3 LYS A  14
ILE A 396
PHE A 399
 None
 0.75A 3j7zS-5v1sA:
undetectable
3j7za-5v1sA:
undetectable		 3j7zS-5v1sA:
13.33
3j7za-5v1sA:
4.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 VAL A 386
GLY A 360
SER A 358
ASN A 359
ILE A 356
 None
 1.14A 3k13A-5v1sA:
6.7		 3k13A-5v1sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 VAL A 386
GLY A 360
SER A 358
ASN A 359
ILE A 356
 None
 1.16A 3k13B-5v1sA:
6.5		 3k13B-5v1sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 VAL A 386
GLY A 360
SER A 358
ASN A 359
ILE A 356
 None
 1.14A 3k13C-5v1sA:
6.9		 3k13C-5v1sA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_A_SAMA406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 PHE A 123
CYH A 124
GLU A 161
PRO A 162
VAL A 249
 SAM  A 604 (-4.8A)
SF4  A 601 ( 2.2A)
SAM  A 604 (-4.4A)
None
SAM  A 604 (-4.2A)
 0.41A 3rfaA-5v1sA:
7.9		 3rfaA-5v1sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFA_B_SAMB406_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE N)		 5v1s RADICAL SAM
(Streptococcus
suis) 		6 / 12 PHE A 123
CYH A 124
GLU A 161
PRO A 162
SER A 210
VAL A 249
 SAM  A 604 (-4.8A)
SF4  A 601 ( 2.2A)
SAM  A 604 (-4.4A)
None
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.53A 3rfaB-5v1sA:
0.0		 3rfaB-5v1sA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 ILE A 173
ALA A 137
ILE A 168
THR A 182
LEU A 199
 None
 1.10A 4cd2A-5v1sA:
undetectable		 4cd2A-5v1sA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 GLU A 176
LEU A 144
ALA A 137
GLU A 177
ASN A 170
 None
 1.46A 4cpzA-5v1sA:
undetectable		 4cpzA-5v1sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 GLU A 176
LEU A 144
ALA A 137
GLU A 177
ASN A 170
 None
 1.46A 4cpzD-5v1sA:
undetectable		 4cpzD-5v1sA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 10 ILE A 191
PRO A 162
ILE A 168
LEU A 172
ILE A 184
 None
 0.72A 4dt8B-5v1sA:
undetectable		 4dt8B-5v1sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 10 ILE A 191
PRO A 162
ILE A 168
LEU A 172
ILE A 184
 None
 0.93A 4dtaA-5v1sA:
undetectable		 4dtaA-5v1sA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 6 ARG A 348
GLY A 320
ASN A 247
GLU A 319
 None
None
SAM  A 604 (-3.8A)
None
 1.15A 4g0vB-5v1sA:
undetectable		 4g0vB-5v1sA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5v1s RADICAL SAM
(Streptococcus
suis) 		5 / 12 PHE A 125
GLU A 161
ASN A 187
SER A 210
VAL A 249
 SAM  A 604 (-4.8A)
SAM  A 604 (-4.4A)
SF4  A 601 (-4.4A)
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
 0.71A 4k39A-5v1sA:
23.3		 4k39A-5v1sA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 7 ILE A  18
LEU A  30
GLY A  16
GLY A  17
 None
 0.86A 5a06B-5v1sA:
undetectable		 5a06B-5v1sA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 5 GLU A  29
GLU A  13
GLU A 339
PHE A  15
 None
 1.26A 5onlA-5v1sA:
undetectable		 5onlA-5v1sA:
19.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V1S_A_SAMA604_0
(RADICAL SAM)		 5v1s RADICAL SAM
(Streptococcus
suis) 		9 / 9 LEU A 158
GLU A 161
THR A 185
SER A 210
GLN A 212
ASN A 247
VAL A 249
TYR A 278
SER A 279
 SAM  A 604 ( 4.0A)
SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 ( 4.1A)
SAM  A 604 (-3.8A)
SAM  A 604 (-4.2A)
SAM  A 604 ( 4.9A)
SAM  A 604 (-4.9A)
 0.03A 5v1sA-5v1sA:
65.5		 5v1sA-5v1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V1S_B_SAMB604_0
(RADICAL SAM)		 5v1s RADICAL SAM
(Streptococcus
suis) 		9 / 9 CYH A 117
LEU A 126
GLU A 161
THR A 185
SER A 210
ASN A 247
VAL A 249
TYR A 278
SER A 279
 SF4  A 601 (-2.2A)
None
SAM  A 604 (-4.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-2.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-4.2A)
SAM  A 604 ( 4.9A)
SAM  A 604 (-4.9A)
 0.49A 5v1sB-5v1sA:
57.8		 5v1sB-5v1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5v1s RADICAL SAM
(Streptococcus
suis) 		10 / 12 LEU A 158
THR A 185
VAL A 208
SER A 210
ASN A 247
VAL A 249
TYR A 278
SER A 279
THR A 285
GLU A 319
 SAM  A 604 ( 4.0A)
SAM  A 604 (-3.8A)
None
SAM  A 604 (-2.4A)
SAM  A 604 (-3.8A)
SAM  A 604 (-4.2A)
SAM  A 604 ( 4.9A)
SAM  A 604 (-4.9A)
None
None
 0.52A 5v1tA-5v1sA:
56.5		 5v1tA-5v1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5v1s RADICAL SAM
(Streptococcus
suis) 		8 / 12 LEU A 158
THR A 185
VAL A 208
SER A 210
VAL A 249
ARG A 272
TYR A 278
GLU A 319
 SAM  A 604 ( 4.0A)
SAM  A 604 (-3.8A)
None
SAM  A 604 (-2.4A)
SAM  A 604 (-4.2A)
None
SAM  A 604 ( 4.9A)
None
 0.61A 5v1tA-5v1sA:
56.5		 5v1tA-5v1sA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V1T_A_SAMA605_0
(RADICAL SAM)		 5v1s RADICAL SAM
(Streptococcus
suis) 		6 / 12 PHE A 125
ASN A 247
VAL A 249
TYR A 278
THR A 285
GLU A 319
 SAM  A 604 (-4.8A)
SAM  A 604 (-3.8A)
SAM  A 604 (-4.2A)
SAM  A 604 ( 4.9A)
None
None
 0.91A 5v1tA-5v1sA:
56.5		 5v1tA-5v1sA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 5v1s RADICAL SAM
(Streptococcus
suis) 		4 / 5 GLU A  29
GLU A  13
GLU A 339
PHE A  15
 None
 1.26A 6hrjA-5v1sA:
undetectable		 6hrjA-5v1sA:
20.00