SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		6 / 12 VAL A  91
VAL A  79
LEU A  76
GLY A 115
ALA A 116
LEU A 113
 None
 1.46A 1eqhA-5v2mA:
undetectable		 1eqhA-5v2mA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 LEU A 110
LEU A 113
ALA A 114
LEU A 133
ILE A  26
 None
None
None
None
SO4  A 401 ( 4.3A)
 1.12A 1g50A-5v2mA:
undetectable		 1g50A-5v2mA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.77A 1grmA-5v2mA:
undetectable		 1grmA-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.77A 1grmB-5v2mA:
undetectable		 1grmB-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 8 GLN A  81
LEU A 133
ARG A 136
LEU A 113
 None
 0.96A 1hk3A-5v2mA:
undetectable		 1hk3A-5v2mA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.73A 1jnoA-5v2mA:
undetectable		 1jnoA-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.73A 1jnoB-5v2mA:
undetectable		 1jnoB-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.76A 1jo3A-5v2mA:
undetectable		 1jo3A-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.76A 1jo3B-5v2mA:
undetectable		 1jo3B-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.64A 1jo4A-5v2mA:
undetectable		 1jo4A-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.64A 1jo4B-5v2mA:
undetectable		 1jo4B-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 7 SER A 131
ALA A 141
SER A 161
ALA A 163
 None
 0.84A 1k5qA-5v2mA:
undetectable
1k5qB-5v2mA:
undetectable		 1k5qA-5v2mA:
20.78
1k5qB-5v2mA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.77A 1magA-5v2mA:
undetectable		 1magA-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.77A 1magB-5v2mA:
undetectable		 1magB-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.70A 1ng8A-5v2mA:
undetectable		 1ng8A-5v2mA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.70A 1ng8B-5v2mA:
undetectable		 1ng8B-5v2mA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.66A 1nrmA-5v2mA:
undetectable		 1nrmA-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.66A 1nrmB-5v2mA:
undetectable		 1nrmB-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.71A 1nruA-5v2mA:
undetectable		 1nruA-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.71A 1nruB-5v2mA:
undetectable		 1nruB-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 ILE A 321
ALA A 111
ALA A 114
LEU A 133
ALA A 141
 None
 1.04A 2aclE-5v2mA:
undetectable		 2aclE-5v2mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 7 GLY A 194
THR A 198
TYR A 205
ASP A 193
 None
 1.01A 2g70A-5v2mA:
undetectable		 2g70A-5v2mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 7 GLY A 194
THR A 198
TYR A 205
ASP A 193
 None
 1.06A 2g70B-5v2mA:
undetectable		 2g70B-5v2mA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 7 SER A 144
ALA A 141
SER A 140
SER A 108
 None
None
SO4  A 401 (-4.4A)
None
 1.02A 2i91A-5v2mA:
undetectable		 2i91A-5v2mA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 7 SER A 144
ALA A 141
SER A 140
SER A 108
 None
None
SO4  A 401 (-4.4A)
None
 1.01A 2i91B-5v2mA:
undetectable		 2i91B-5v2mA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 12 ALA A 104
THR A  10
ALA A 150
ALA A 163
MET A 195
 None
None
None
None
SO4  A 401 ( 4.4A)
 1.12A 2nyrA-5v2mA:
undetectable		 2nyrA-5v2mA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 7 ILE A 180
ILE A 235
LEU A 312
LEU A  37
 None
 0.76A 3adxA-5v2mA:
undetectable		 3adxA-5v2mA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 6 ILE A  15
GLU A 213
LYS A 214
ASN A 211
 None
 1.43A 3kp6A-5v2mA:
undetectable
3kp6B-5v2mA:
undetectable		 3kp6A-5v2mA:
17.77
3kp6B-5v2mA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 GLY A 137
LEU A  76
ASN A  77
LEU A 113
LEU A 110
 None
 1.27A 3ndvA-5v2mA:
undetectable
3ndvB-5v2mA:
undetectable		 3ndvA-5v2mA:
22.98
3ndvB-5v2mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 LEU A 113
LEU A 110
GLY A 137
LEU A  76
ASN A  77
 None
 1.26A 3ndvA-5v2mA:
undetectable
3ndvB-5v2mA:
undetectable		 3ndvA-5v2mA:
22.98
3ndvB-5v2mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 GLY A 137
LEU A  76
ASN A  77
LEU A 113
LEU A 110
 None
 1.26A 3ndvC-5v2mA:
undetectable
3ndvD-5v2mA:
undetectable		 3ndvC-5v2mA:
22.98
3ndvD-5v2mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 LEU A 113
LEU A 110
GLY A 137
LEU A  76
ASN A  77
 None
 1.28A 3ndvC-5v2mA:
undetectable
3ndvD-5v2mA:
undetectable		 3ndvC-5v2mA:
22.98
3ndvD-5v2mA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 11 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.13A 3pghB-5v2mA:
undetectable		 3pghB-5v2mA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		3 / 3 LYS A 294
GLU A 292
TRP A 171
 None
 0.99A 3v4tH-5v2mA:
undetectable		 3v4tH-5v2mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 6 ILE A 235
VAL A 289
LEU A 299
CYH A 277
 None
 0.79A 4asdA-5v2mA:
undetectable		 4asdA-5v2mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 5 GLN A 218
HIS A 220
ILE A 234
ILE A  15
 None
 0.84A 5dnuA-5v2mA:
undetectable		 5dnuA-5v2mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		4 / 5 GLN A 218
HIS A 220
ILE A 234
ILE A  15
 None
 0.81A 5dnvA-5v2mA:
undetectable		 5dnvA-5v2mA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 12 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.11A 5ikrB-5v2mA:
undetectable		 5ikrB-5v2mA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 12 LEU A 121
LEU A 133
VAL A  46
GLY A   4
ALA A 116
 None
 1.06A 5jw1B-5v2mA:
undetectable		 5jw1B-5v2mA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Enterococcus
faecalis) 		5 / 12 LEU A 110
GLY A 115
ALA A 134
GLU A 325
PHE A 324
 None
 1.31A 5x6yC-5v2mA:
undetectable		 5x6yC-5v2mA:
17.67