SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 9 GLY A  46
GLY A 141
GLY A 140
ASP A 303
ARG A 263
 FAD  A 501 ( 3.7A)
None
FAD  A 501 (-3.3A)
FAD  A 501 (-2.9A)
FAD  A 501 ( 3.7A)
 1.08A 1mxdA-5v36A:
undetectable		 1mxdA-5v36A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 GLY A  46
GLY A 141
GLY A 140
ASP A 303
ARG A 263
 FAD  A 501 ( 3.7A)
None
FAD  A 501 (-3.3A)
FAD  A 501 (-2.9A)
FAD  A 501 ( 3.7A)
 1.07A 1mxgA-5v36A:
undetectable		 1mxgA-5v36A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 11 GLY A 404
GLU A 356
GLU A 209
SER A 351
ILE A 402
 None
 1.46A 1odiB-5v36A:
undetectable		 1odiB-5v36A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 7 PHE A 270
THR A 267
VAL A 304
VAL A 277
 FAD  A 501 ( 4.2A)
None
None
None
 0.96A 2cppA-5v36A:
undetectable		 2cppA-5v36A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 4 ALA A 115
VAL A   9
PHE A 117
THR A 139
 FAD  A 501 (-3.7A)
None
None
FAD  A 501 (-4.0A)
 1.44A 2pkkA-5v36A:
5.5		 2pkkA-5v36A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 4 TYR A 299
LEU A 301
LEU A 321
HIS A 134
 None
 1.47A 2x7hB-5v36A:
3.7		 2x7hB-5v36A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 10 ILE A 349
LEU A 195
LEU A 203
GLY A 176
ALA A 179
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.15A 2xf3A-5v36A:
undetectable		 2xf3A-5v36A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 8 ARG A 324
PHE A 326
PRO A 133
GLY A 297
 None
 0.85A 2y6rB-5v36A:
10.9		 2y6rB-5v36A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 THR A  41
GLY A  15
GLY A  12
LEU A 301
ASN A 305
 FAD  A 501 (-3.5A)
FAD  A 501 (-3.5A)
FAD  A 501 ( 4.9A)
None
None
 1.08A 2zw9B-5v36A:
undetectable		 2zw9B-5v36A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 THR A  41
GLY A  16
GLY A  12
LEU A 301
ASN A 305
 FAD  A 501 (-3.5A)
None
FAD  A 501 ( 4.9A)
None
None
 1.11A 2zw9B-5v36A:
undetectable		 2zw9B-5v36A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 8 VAL A 180
GLY A 184
PRO A 223
LYS A  51
 None
 0.91A 3bjwA-5v36A:
undetectable		 3bjwA-5v36A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 5 ASN A 266
ALA A 115
LEU A  32
GLY A  12
 None
FAD  A 501 (-3.7A)
None
FAD  A 501 ( 4.9A)
 0.93A 3dl9A-5v36A:
undetectable		 3dl9A-5v36A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 5 ILE A  92
HIS A  96
VAL A  38
ASN A  44
 None
 1.49A 3nneA-5v36A:
10.8		 3nneA-5v36A:
25.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 TYR A   7
GLY A  15
GLY A  39
ALA A 317
LEU A 301
 None
FAD  A 501 (-3.5A)
None
None
None
 1.12A 3vywC-5v36A:
undetectable		 3vywC-5v36A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		3 / 3 GLU A 323
ARG A  22
HIS A  26
 SO4  A 519 ( 4.8A)
SO4  A 519 ( 3.0A)
None
 0.70A 4kf9A-5v36A:
undetectable		 4kf9A-5v36A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 8 PHE A 270
THR A 267
VAL A 304
VAL A 277
 FAD  A 501 ( 4.2A)
None
None
None
 0.93A 4l4dA-5v36A:
undetectable		 4l4dA-5v36A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 9 LEU A 244
LEU A 186
THR A 256
LEU A 257
ILE A 258
 None
 1.23A 4ubsA-5v36A:
undetectable		 4ubsA-5v36A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 ILE A 137
LEU A 321
GLY A 276
LEU A 279
THR A 278
 None
 1.19A 5byjA-5v36A:
undetectable		 5byjA-5v36A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		4 / 5 LEU A 321
ALA A  23
LEU A 325
VAL A 108
 None
 1.17A 5cr1A-5v36A:
undetectable		 5cr1A-5v36A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 ILE A 178
ALA A 179
GLY A 141
GLY A 262
GLY A  46
 FAD  A 501 ( 4.1A)
None
None
CL  A 505 (-3.4A)
FAD  A 501 ( 3.7A)
 1.02A 5i75A-5v36A:
0.5		 5i75A-5v36A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 THR A 170
ALA A 188
GLY A 184
ALA A  60
GLY A 190
 None
None
None
None
EPE  A 526 (-3.8A)
 1.36A 5jglB-5v36A:
undetectable		 5jglB-5v36A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 ALA A 138
LEU A 301
ALA A 300
THR A 293
LEU A 272
 FAD  A 501 (-4.8A)
None
None
None
None
 1.21A 5k9dA-5v36A:
undetectable		 5k9dA-5v36A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 SER A 191
PHE A 160
ILE A 166
ALA A 165
GLY A 154
 None
None
EPE  A 526 (-4.5A)
None
None
 1.11A 5veuA-5v36A:
undetectable		 5veuA-5v36A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 9 VAL A 215
VAL A 197
LEU A 214
GLY A 176
LEU A 203
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.33A 6czmA-5v36A:
undetectable
6czmB-5v36A:
undetectable		 6czmA-5v36A:
22.22
6czmB-5v36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 9 VAL A 215
VAL A 197
LEU A 214
GLY A 176
LEU A 203
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.35A 6czmB-5v36A:
undetectable
6czmC-5v36A:
undetectable		 6czmB-5v36A:
22.22
6czmC-5v36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 9 VAL A 215
VAL A 197
LEU A 214
GLY A 176
LEU A 203
 None
None
None
SO4  A 513 ( 3.9A)
None
 1.35A 6czmD-5v36A:
undetectable
6czmE-5v36A:
undetectable		 6czmD-5v36A:
22.22
6czmE-5v36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 10 GLY A  11
GLY A  13
GLU A  34
THR A 139
ASN A 266
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-4.0A)
None
 0.90A 6exiA-5v36A:
undetectable		 6exiA-5v36A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 10 GLY A  11
GLY A  13
GLU A  34
THR A 139
ASN A 266
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-4.0A)
None
 0.93A 6exiB-5v36A:
2.7		 6exiB-5v36A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 GLY A  11
GLY A  13
GLU A  34
THR A 139
ASN A 266
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-4.0A)
None
 0.93A 6exiC-5v36A:
2.9
6exiD-5v36A:
2.9		 6exiC-5v36A:
12.06
6exiD-5v36A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		5 / 12 GLY A  11
GLY A  13
GLU A  34
THR A 139
ASN A 266
 FAD  A 501 (-3.2A)
FAD  A 501 (-3.3A)
FAD  A 501 (-2.7A)
FAD  A 501 (-4.0A)
None
 0.91A 6exiC-5v36A:
2.6
6exiD-5v36A:
2.9		 6exiC-5v36A:
12.06
6exiD-5v36A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5v36 GLUTATHIONE
REDUCTASE
(Streptococcus
mutans) 		6 / 7 GLY A  35
LYS A  36
TYR A 114
HIS A 142
ASN A 266
GLY A 269
 FAD  A 501 (-4.1A)
None
FAD  A 501 (-3.4A)
GOL  A 524 (-3.8A)
None
GOL  A 523 (-3.3A)
 0.62A 6n7fA-5v36A:
57.4		 6n7fA-5v36A:
16.09