SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v38'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 5v38 HCHA
(Clostridium
botulinum) 		5 / 12 THR A 982
GLY A1037
ASN A 925
ILE A 923
LEU A 918
 None
 1.20A 1r30A-5v38A:
undetectable		 1r30A-5v38A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 5v38 HCHA
(Clostridium
botulinum) 		5 / 12 THR A 982
GLY A1037
ASN A 925
ILE A 923
LEU A 918
 None
 1.20A 1r30B-5v38A:
undetectable		 1r30B-5v38A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5v38 HCHA
(Clostridium
botulinum) 		3 / 3 ASN A1230
TYR A1259
SER A1256
 None
 0.93A 2gvcB-5v38A:
undetectable		 2gvcB-5v38A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5v38 HCHA
(Clostridium
botulinum) 		5 / 11 LEU A1036
THR A 988
ILE A 985
MET A 956
VAL A 990
 None
 1.25A 2n27A-5v38A:
undetectable		 2n27A-5v38A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5v38 HCHA
(Clostridium
botulinum) 		4 / 7 GLN A 995
TYR A 993
TYR A 950
ILE A 952
 None
 1.28A 2ph9A-5v38A:
undetectable
2ph9B-5v38A:
undetectable		 2ph9A-5v38A:
18.12
2ph9B-5v38A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5v38 HCHA
(Clostridium
botulinum) 		4 / 7 ASP A1163
ARG A1167
ILE A1088
TYR A1099
 None
 1.01A 2yfbA-5v38A:
undetectable		 2yfbA-5v38A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5v38 HCHA
(Clostridium
botulinum) 		4 / 6 ASP A1163
ARG A1167
ILE A1088
TYR A1099
 None
 1.04A 2yfbB-5v38A:
undetectable		 2yfbB-5v38A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5v38 HCHA
(Clostridium
botulinum) 		6 / 12 ILE A1045
LEU A 918
ILE A 953
ILE A 866
PHE A1064
VAL A1009
 None
None
None
ACY  A1304 ( 4.9A)
None
None
 1.40A 2ygqA-5v38A:
undetectable		 2ygqA-5v38A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5v38 HCHA
(Clostridium
botulinum) 		4 / 5 SER A 912
LEU A 906
GLN A 905
LYS A 895
 None
 1.36A 3pgyB-5v38A:
undetectable		 3pgyB-5v38A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5v38 HCHA
(Clostridium
botulinum) 		5 / 9 ARG A1132
GLY A1130
LEU A1128
ASP A1110
ASN A1112
 None
 1.47A 3wdmA-5v38A:
undetectable		 3wdmA-5v38A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5v38 HCHA
(Clostridium
botulinum) 		3 / 3 CYH A1227
ASN A1168
LYS A1090
 None
 1.40A 4k50A-5v38A:
undetectable		 4k50A-5v38A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 5v38 HCHA
(Clostridium
botulinum) 		3 / 3 CYH A1227
ASN A1219
LYS A1090
 None
 1.00A 4k50A-5v38A:
undetectable		 4k50A-5v38A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5v38 HCHA
(Clostridium
botulinum) 		5 / 12 TYR A 942
ILE A1003
ILE A1007
ILE A 937
ILE A 976
 None
 1.12A 5hw8B-5v38A:
undetectable
5hw8F-5v38A:
undetectable
5hw8G-5v38A:
undetectable		 5hw8B-5v38A:
14.25
5hw8F-5v38A:
14.25
5hw8G-5v38A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5v38 HCHA
(Clostridium
botulinum) 		3 / 3 TYR A 863
ASN A1065
LEU A1079
 None
 0.77A 6b58A-5v38A:
undetectable		 6b58A-5v38A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5v38 HCHA
(Clostridium
botulinum) 		5 / 12 PHE A1047
GLY A 893
ASP A1050
ILE A1045
SER A 907
 ACY  A1302 (-3.8A)
None
None
None
None
 0.87A 6mhtA-5v38A:
undetectable		 6mhtA-5v38A:
25.00