SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A1556
GLY A1557
LEU A1558
TYR A1658
VAL A1687
 None
 1.09A 1a27A-5v41A:
4.6		 1a27A-5v41A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 GLY A1712
LEU A1487
VAL A1471
LEU A1719
ALA A1718
 None
 1.06A 1gseB-5v41A:
undetectable		 1gseB-5v41A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 ALA A1702
ILE A1703
ILE A1707
VAL A1711
LEU A1491
 None
 1.11A 1xozA-5v41A:
undetectable		 1xozA-5v41A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 TYR A1663
GLY A1681
TYR A1674
ASP A1680
 J24  A1801 (-4.3A)
None
J24  A1801 (-3.8A)
None
 1.28A 2g72A-5v41A:
undetectable		 2g72A-5v41A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		3 / 3 PRO A1476
GLU A1485
TYR A1484
 None
 0.57A 2zmbA-5v41A:
undetectable		 2zmbA-5v41A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 7 TYR A1637
VAL A1611
ILE A1575
GLY A1609
 J24  A1801 (-4.3A)
None
None
None
 0.99A 3gssA-5v41A:
undetectable		 3gssA-5v41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 7 TYR A1637
VAL A1611
ILE A1575
GLY A1609
 J24  A1801 (-4.3A)
None
None
None
 0.99A 3gssB-5v41A:
undetectable		 3gssB-5v41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 HIS A1714
VAL A1655
LEU A1690
ALA A1718
GLY A1531
 None
 1.07A 3ln1A-5v41A:
0.5		 3ln1A-5v41A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 HIS A1714
VAL A1655
LEU A1690
ALA A1718
GLY A1531
 None
 1.07A 3ln1B-5v41A:
undetectable		 3ln1B-5v41A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 HIS A1714
VAL A1655
LEU A1690
ALA A1718
GLY A1531
 None
 1.08A 3ln1C-5v41A:
undetectable		 3ln1C-5v41A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 HIS A1714
VAL A1655
LEU A1690
ALA A1718
GLY A1531
 None
 1.08A 3ln1D-5v41A:
undetectable		 3ln1D-5v41A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 GLY A1505
LEU A1638
GLU A1509
ASP A1606
 None
 1.01A 3ps9A-5v41A:
undetectable		 3ps9A-5v41A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 TYR A1663
TYR A1674
ASP A1639
ALA A1477
ALA A1642
 J24  A1801 (-4.3A)
J24  A1801 (-3.8A)
None
None
None
 1.50A 3rodC-5v41A:
1.2		 3rodC-5v41A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 7 ILE A1544
ILE A1648
LEU A1558
VAL A1556
 None
 0.87A 3ua5B-5v41A:
undetectable		 3ua5B-5v41A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 GLU A1504
ARG A1510
ARG A1634
GLU A1608
 None
 1.26A 4kr3A-5v41A:
2.7		 4kr3A-5v41A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 4 THR A1481
GLY A1478
ASP A1639
SER A1480
 None
 1.22A 4rfqA-5v41A:
3.1		 4rfqA-5v41A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 LEU A1657
GLY A1531
GLY A1536
ILE A1695
ALA A1702
 None
 1.01A 5l0zB-5v41A:
3.1		 5l0zB-5v41A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLU A1485
VAL A1473
GLY A1489
LEU A1491
 None
 0.98A 5sxqB-5v41A:
undetectable		 5sxqB-5v41A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 8 GLU A1485
VAL A1473
GLY A1489
LEU A1491
 None
 0.99A 5syjA-5v41A:
undetectable		 5syjA-5v41A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 LEU A1518
VAL A1473
VAL A1456
GLY A1499
LEU A1529
 None
 1.23A 6bsgA-5v41A:
undetectable		 6bsgA-5v41A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 LEU A1518
VAL A1473
VAL A1456
GLY A1499
LEU A1529
 None
 1.19A 6bsiA-5v41A:
undetectable		 6bsiA-5v41A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 LEU A1518
VAL A1473
VAL A1456
GLY A1499
LEU A1529
 None
 1.23A 6bsjA-5v41A:
undetectable		 6bsjA-5v41A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A1629
THR A1635
VAL A1614
VAL A1618
ILE A1625
 None
 1.07A 6emuC-5v41A:
undetectable		 6emuC-5v41A:
21.60