SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v44'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 5v44 SACSIN
(Homo
sapiens) 		4 / 8 HIS A 218
ASP A 216
SER A 145
ASP A 202
 None
 1.20A 2obvA-5v44A:
undetectable		 2obvA-5v44A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5v44 SACSIN
(Homo
sapiens) 		4 / 8 TYR A 157
TYR A 138
GLY A 252
ILE A 253
 None
None
None
GOL  A 403 (-4.6A)
 0.88A 2zm9A-5v44A:
undetectable		 2zm9A-5v44A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5v44 SACSIN
(Homo
sapiens) 		3 / 3 LYS A 101
VAL A  97
HIS A 218
 None
 0.92A 3tj7A-5v44A:
undetectable		 3tj7A-5v44A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5v44 SACSIN
(Homo
sapiens) 		4 / 5 PHE A 194
PHE A 271
ILE A 206
THR A 269
 None
 0.91A 4ejjC-5v44A:
undetectable		 4ejjC-5v44A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5v44 SACSIN
(Homo
sapiens) 		4 / 8 HIS A 218
ASP A 216
SER A 145
ASP A 202
 None
 1.21A 4kttA-5v44A:
undetectable		 4kttA-5v44A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5v44 SACSIN
(Homo
sapiens) 		4 / 8 HIS A 218
ASP A 216
SER A 145
ASP A 202
 None
 1.21A 4kttC-5v44A:
undetectable		 4kttC-5v44A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5v44 SACSIN
(Homo
sapiens) 		4 / 7 HIS A 218
ASP A 216
SER A 145
ASP A 202
 None
 1.29A 4ndnC-5v44A:
undetectable		 4ndnC-5v44A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5v44 SACSIN
(Homo
sapiens) 		4 / 7 HIS A 218
ASP A 216
SER A 145
ASP A 202
 None
 1.21A 4odjA-5v44A:
undetectable		 4odjA-5v44A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5v44 SACSIN
(Homo
sapiens) 		4 / 7 HIS A 218
ASP A 216
SER A 145
ASP A 202
 None
 1.33A 5a1iA-5v44A:
undetectable		 5a1iA-5v44A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5v44 SACSIN
(Homo
sapiens) 		5 / 12 GLY A 325
VAL A 330
ARG A 321
VAL A 320
ASP A 134
 None
None
GOL  A 403 ( 4.9A)
None
None
 1.40A 6bxlB-5v44A:
undetectable		 6bxlB-5v44A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5v44 SACSIN
(Homo
sapiens) 		5 / 11 ALA A 303
LEU A 307
VAL A 306
VAL A 313
ALA A 121
 None
 1.04A 6h1lB-5v44A:
undetectable		 6h1lB-5v44A:
21.41