SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5v4a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		5 / 12 ILE A 183
ALA A 186
LEU A 144
ALA A 269
LEU A 211
 None
 1.05A 1xiuB-5v4aA:
undetectable		 1xiuB-5v4aA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		5 / 10 GLU A 248
ARG A 116
GLY A  29
LEU A  50
ILE A  41
 None
UDP  A 301 (-4.1A)
None
None
None
 1.26A 3adsA-5v4aA:
undetectable		 3adsA-5v4aA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		3 / 3 LEU A 143
VAL A 187
ARG A 194
 None
 0.82A 3b0wB-5v4aA:
undetectable		 3b0wB-5v4aA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		4 / 6 GLY A 154
TYR A 228
GLU A 229
GLY A 156
 None
 1.03A 3e9rA-5v4aA:
undetectable		 3e9rA-5v4aA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		4 / 6 GLY A 154
TYR A 228
GLU A 229
GLY A 156
 None
 1.02A 3e9rC-5v4aA:
undetectable		 3e9rC-5v4aA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		4 / 6 HIS A 223
GLU A 147
ASP A 260
ASN A 157
 UDP  A 301 (-3.5A)
None
None
None
 1.30A 3vywA-5v4aA:
undetectable		 3vywA-5v4aA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		5 / 12 LEU A 207
ILE A 169
ILE A 196
PHE A 160
TYR A 263
 None
 1.46A 4a79B-5v4aA:
undetectable		 4a79B-5v4aA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		4 / 5 HIS A 190
VAL A 187
GLU A 189
VAL A 268
 None
 1.45A 4p6vB-5v4aA:
undetectable
4p6vE-5v4aA:
undetectable		 4p6vB-5v4aA:
21.26
4p6vE-5v4aA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		5 / 12 ALA A 191
ILE A  41
TYR A  43
GLY A  29
THR A 112
 None
None
UDP  A 301 (-3.4A)
None
None
 1.01A 5jlcA-5v4aA:
undetectable		 5jlcA-5v4aA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		4 / 6 ILE A 119
ILE A 221
LEU A 134
PHE A 131
 None
 1.06A 5vkqA-5v4aA:
undetectable
5vkqB-5v4aA:
undetectable		 5vkqA-5v4aA:
9.48
5vkqB-5v4aA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		4 / 6 ILE A 119
ILE A 221
LEU A 134
PHE A 131
 None
 1.04A 5vkqA-5v4aA:
undetectable
5vkqD-5v4aA:
undetectable		 5vkqA-5v4aA:
9.48
5vkqD-5v4aA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5v4a GLYCOSYLTRANSFERASE
(DUF1792)
(Streptococcus
sanguinis) 		5 / 12 ILE A 183
ALA A 186
LEU A 144
ALA A 269
LEU A 211
 None
 1.04A 6a60D-5v4aA:
undetectable		 6a60D-5v4aA:
16.23